Abstract：
:Brain/kidney (B/K) protein is a new protein of 474 amino acids, which contains two C2 domains structurally homologous to those present in synaptotagmins. The expression of B/K protein was identified in the rat retina and B/K protein immunoreactivity was localized to a number of ganglion cells, a few amacrine cells and the radial processes of Müller cells. Thus, B/K protein appears to be important in the homeostasis in these cells of the rat retina.
journal_name
Brain Resjournal_title
Brain researchauthors
Kwon OJ,Ju WK,Choi SH,Lee MY,Oh SJ,Chun MHdoi
10.1016/s0006-8993(00)02014-xsubject
Has Abstractpub_date
2000-03-31 00:00:00pages
178-80issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02014-Xjournal_volume
860pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Antipsychotic drugs are the main treatment for schizophrenia, despite their adverse side effects and uncertain mode of action. Gene expression studies in the brains of rodents treated with antipsychotic drugs aim to uncover this mechanism and elucidate more specific targets for schizophrenia treatment. Previous expres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.045
更新日期：2009-12-22 00:00:00
abstract：:An expanding body of data has indicated that the seizure prone state in genetically epilepsy-prone rats (GEPRs) is partially caused by deficits in central nervous system noradrenergic transmission. Several lines of evidence suggest that the noradrenergic terminals in the superior colliculus (SC) may act as determinant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01139-6
更新日期：1998-01-12 00:00:00
abstract：:Neuronal expression of c-fos product in the cat rostral ventrolateral medulla was studied by immunohistochemistry. Spinally projecting neurons of the subretrofacial (SRF) nucleus were pre-labeled by retrograde transport of fluorescent latex microspheres from the lumbar cord. In 3 animals which were bled by approximate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90099-u
更新日期：1992-03-20 00:00:00
abstract：:Cocaine increases dopamine concentration in the nucleus accumbens through competitive binding to the dopamine transporter (DAT). However, it also increases the frequency of dopamine release events, a finding that cannot be explained by action at the DAT alone. Rather, this effect may be mediated by cocaine-induced mod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.022
更新日期：2017-01-15 00:00:00
abstract：:The preferential loss of GABAergic neurons in neocortex slab cultures after exposure to hypoxia was reinvestigated and confirmed using an improved morphometric analysis based on stereological principles. This preferential cell loss could be attenuated by treating the hypoxic slab cultures with the N-methyl-D-aspartate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91031-7
更新日期：1989-10-30 00:00:00
abstract：:To investigate the effects of ionic changes possibly associated with hibernation, hippocampal slices prepared from golden hamsters were studied in artificial cerebrospinal fluid (ACSF) of variable composition (K+ 3-5 mM, Ca2+ 2-4 mM, Mg2+ 2-4 mM, pH 7.0-7.7) at temperatures of 15-20 degrees C, just above the temperatu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00524-t
更新日期：1995-08-14 00:00:00
abstract：:Brain protein kinase B (Akt) and glycogen synthase kinase-3 (GSK-3) activities are adaptable to changes of peripheral blood glucose level in vivo. GSK-3 phosphorylates microtube-associated protein tau at multiple sites, which can be antagonized by protein phosphatase-2A (PP-2A). The imbalance among these enzymes might...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.084
更新日期：2011-04-06 00:00:00
abstract：:We showed previously, using in vitro microdialysis, that the activation of the soluble guanylate cyclase (sGC)/cyclic GMP pathway was the underlying mechanism of the extracellular Ca(2+)-dependent effects of exogenous NO on dopamine (DA) secretion from PC12 cells. In this study, the co-infusion of the sGC inhibitor 1H...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.040
更新日期：2004-10-15 00:00:00
abstract：:The blink reflex consists of an early, pontine R1-component and a late, medullary R2-component. R1 and R2 can be evoked by innocuous stimuli, but only the R2 also by painful heat, suggesting that the R2 is mediated by wide dynamic range neurons (WDR) of the spinal trigeminal nucleus. Remote noxious stimuli suppress th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00646-5
更新日期：1998-08-24 00:00:00
abstract：:The solubilized rat central nervous system (hypothalamic) nicotinic cholinergic receptor and the Torpedo nicotinic cholinergic receptors are immunologically similar and show greater than 60% immunologic cross-reactivity using a double-antibody technique. Antibodies to the Electrophorus and Torpedo receptors also decre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90700-5
更新日期：1979-12-14 00:00:00
abstract：:Chronic developmental exposure to ethanol can lead to a wide variety of teratogenic effects, which in humans are known as fetal alcohol spectrum disorders (FASD). Individuals affected by FASD may exhibit persistent impairments to cognitive functions such as learning, memory, and attention, which are highly dependent o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.10.005
更新日期：2018-01-01 00:00:00
abstract：:The effects of cocaine administration and withdrawal on D1 and D2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in the number and agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90255-0
更新日期：1994-01-14 00:00:00
abstract：:Serotonin 1A (5HT1A) receptor agonists have shown neuroprotective properties in different models of central nervous system injury. Activation of neuronal 5HT1A receptors appears to be involved in the neuroprotective effects. It remains to be elucidated if astroglial cells are responsive to the 5HT1A neuroprotective ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.10.019
更新日期：2004-12-31 00:00:00
abstract：:An extract of fetal calf striated muscle was found to support the survival, growth and differentiation of chick ciliary ganglion neurons in dissociated cell culture. The active material was precipitated in a single fraction by 35-60% ammonium sulfate. When this active fraction was passed over a concanavalin A-Sepharos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90229-9
更新日期：1985-03-01 00:00:00
abstract：:Hyperprolinemia type II is an autosomal recessive disorder caused by the severe deficiency of delta(1)-pyrroline-5-carboxylate dehydrogenase activity leading to tissue accumulation of proline (Pro). Most patients detected so far show neurological manifestations including epilepsy and mental retardation, whose pathophy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.08.014
更新日期：2003-11-21 00:00:00
abstract：:Tetramethylpyrazine (TMP) is one of the alkaloids contained in Ligustrazine which has been used in traditional Chinese medicine as an analgesic for injury and dysmenorrhea. ATP can elicit the sensation of pain. This study observed the effects of TMP on ATP-activated current (IATP) in rat DRG neurons. TMP (0.1-1 mM) co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.076
更新日期：2005-04-08 00:00:00
abstract：:Synaptosomes prepared from fresh human cerebral cortex were shown to be morphologically similar to those from other species. On incubation, they took up oxygen at a high and linear rate and accumulated potassium against a concentration gradient. In response to depolarization by raised extracellular K+ or addition of v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90871-4
更新日期：1981-11-16 00:00:00
abstract：:Rat hippocampal minces were loaded with [acetyl 1-14C]acetylcholine ([14C]ACh) in the presence of the "poorly penetrating" acetylcholinesterase (EC 3.1.1.7; AChE) inhibitor echothiophate and the effect of high K+ depolarization determined on the subcellular storage and release of [14C]ACh and its metabolites. Results ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00078-9
更新日期：1996-06-24 00:00:00
abstract：:There exists evidence to support the notion that the segmental reflex system is not fixed and inflexible, but rather is highly modifiable under a variety of circumstances. In this study the H-wave and M-wave recruitment curves were obtained from 19 subjects, utilizing the procedures outlined by Hugon. Each subject was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90495-9
更新日期：1993-11-26 00:00:00
abstract：:Focal adhesion kinase (FAK) and proline-rich tyrosine kinase (PYK2) are two related non-receptor tyrosine kinases which are thought to play a role in transducing extracellular matrix (ECM)-derived survival signals into cells. The functions of FAK and PYK2 are linked to autophosphorylation of their specific tyrosine re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.022
更新日期：2015-05-05 00:00:00
abstract：:In an attempt to determine the basis for apparently conflicting reports of the effects of noradrenaline (NA) on the neurohypophyseal system and its effects on the parvocellular periventricular region of the paraventricular nucleus (PVN), recordings were made from the neurons in the supraoptic nucleus (SON) and the per...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90511-1
更新日期：1986-03-26 00:00:00
abstract：:Recently, missense mutations in the gene TARDBP encoding TDP-43 have been linked to familial ALS. The discovery of genes encoding these RNA binding proteins, such as TDP-43 and FUS/TLS, raised the notion that altered RNA metabolism is a major factor underlying the pathogenesis of ALS. To begin to unravel how mutations...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2012.04.031
更新日期：2012-06-26 00:00:00
abstract：:The production and localization of cell-associated forms of beta-amyloid precursor protein (APP) of Alzheimer's disease was investigated in primary cultures of mouse glial cells. In both oligodendrocytes and astrocytes, immunofluorescence staining with an antibody against the carboxy terminus of APP revealed an intens...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90898-j
更新日期：1992-07-03 00:00:00
abstract：:The conduction velocity of frog ischiadic nerves incubated in vitro in osmolarities between 220 and 1000 mOsm decreased with the degree of fiber shrinkage. The latter (non-circularity factor) was determined from computer-assisted measurements in freeze-substituted or in chemically fixed fibers. Freeze-substituted norm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90546-8
更新日期：1984-04-09 00:00:00
abstract：:Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01500-0
更新日期：1996-04-22 00:00:00
abstract：:Sites which bind oxytocin and vasopressin with high affinity were detected in the brain and upper spinal cord of 12 human subjects, using in vitro light microscopic autoradiography. Tissue sections were incubated with tritiated vasopressin, tritiated oxytocin or an iodinated oxytocin antagonist. The ligand specificity...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90345-v
更新日期：1991-08-02 00:00:00
abstract：:In the previous study, we reported increased NOS expression in the astrocytes in the spinal cord of the transgenic mice that are used as ALS animal model. In the present study, we performed immunocytochemical studies to investigate the changes of nitrotyrosine-immunoreactivity in the brains of the transgenic mice, and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02302-1
更新日期：2000-01-17 00:00:00
abstract：:Diazoxide (DZ), a highly selective opener of the mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel, has neuroprotective effects. However, the mechanism of DZ protecting hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. In this study, we investigated DZ attenuating neuronal los...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.037
更新日期：2011-04-06 00:00:00
abstract：:A phosphorylated, approximately 110 kDa laminin-binding protein (110 kDa LBP) from mouse brain has been previously identified. This protein recognizes a neurite-outgrowth promoting 19-amino acid synthetic peptide (PA 22-2) derived from the laminin A chain. In the present study, an antibody against the 110 kDa LBP was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90356-z
更新日期：1991-08-02 00:00:00
abstract：:The optic nerve of anesthetized cats was completely cut and the autologous sciatic nerve was transplanted. Sixty days later some populations of retinal ganglion cells were shown to regenerate the axon with retrograde HRP labeling. We verified that ganglion cells that had projected to the lateral geniculate nucleus (LG...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91253-w
更新日期：1991-09-27 00:00:00
