Abstract：
:An investigation has been carried out into the physiological properties of tendon organs and their interactions with motor units following two types of nerve injury: nerve crush and nerve transection followed by suture repair. Recovery from nerve crush was very successful: 6 weeks after the injury 60% of the tendon organ-motor unit interactions (n = 62) evoked normal or near-normal patterns of afferent discharge but with reduced firing rates. After 10 weeks of recovery 81% of the interactions (n = 43) were normal. The main abnormality observed was a phasic-only pattern of discharge. The overall reductions in firing rate during early recovery may be attributable to the lower contractile forces generated by the reinnervated muscle units, while the phasic-only responses may also represent immaturity of the transduction mechanism of the regenerated afferent axons. Following nerve transection the quality of recovery was much lower and a range of abnormal, as well as normal patterns of response were observed. For all the afferents studied, both types of response were recorded, suggesting that although there may be changes in the sensitivity of the afferents to muscle contraction, the abnormal responses more probably reflect changes in the form of the mechanical input rather than abnormalities of the transduction process.
journal_name
Brain Resjournal_title
Brain researchauthors
Scott JJ,Davies P,Petit Jdoi
10.1016/0006-8993(95)00847-jsubject
Has Abstractpub_date
1995-10-30 00:00:00pages
225-34issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)00847-Jjournal_volume
697pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Repeating a stimulus generally leads to a decreased response in neural activity compared to that for novel items. This neural attenuation provides a marker for stimulus-specific perceptual encoding and memory that can be detected using functional magnetic resonance imaging (fMRI). Although previously assumed to occur ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.090
更新日期：2006-03-29 00:00:00
abstract：:Numerous studies with PC12 cells have suggested that the mitogen-activated protein (MAP) kinase pathway might play a major role in the neuronal differentiation that is induced by nerve growth factor (NGF). Cells of the PC12D subline extend neurites within several hours in response to NGF in the presence of inhibitors ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01403-0
更新日期：1998-03-02 00:00:00
abstract：:These experiments used in vivo microdialysis and high-performance liquid chromatography to examine, in rats, norepinephrine (NE) release in the amygdala induced by footshock and systemic administration of drugs affecting the opioid peptidergic system. A microdialysis probe was inserted into a previously implanted guid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00795-1
更新日期：1998-10-19 00:00:00
abstract：:Although it has been reported that dendritic neurotransmitter releases from amacrine cells are regulated by the intracellular Ca(2+) concentration ([Ca(2+)](i)), their spatiotemporal patterns are not well explained. Fast Ca(2+) imagings of amacrine cells in the horizontal slice preparation of goldfish retinas under wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.025
更新日期：2004-10-08 00:00:00
abstract：:Seasonally breeding animals undergo numerous physiological changes in response to changes in the length of the photoperiod. In most warm-weather breeding rodents, these changes result in reproductive quiescence during short photoperiods. It has been hypothesized that this change is mediated by changes in the activity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.08.083
更新日期：2007-11-14 00:00:00
abstract：:Recent experimental data have shown that hyperbaric oxygen therapy (HBOT) was associated increased Bcl-2 expression at the injury site that correlated with reduced apoptosis. We hypothesized that HBOT mediated enhancement of Bcl-2 expression and increased intracellular oxygen bio-availability may both contribute to pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.078
更新日期：2008-07-24 00:00:00
abstract：:The purpose of this study was to identify the CNS cellular constituent immunoreactive for specific P2X7 receptor antiserum in the kainate-induced seizure and non-seizure rat brain. Analysis of P2X7 immunocytochemistry (ICC) revealed small immunoreactive cells with processes showing distinct morphological changes as se...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.040
更新日期：2006-05-17 00:00:00
abstract：:The principal finding in this study is that the callosal projection to the occipital cortex in rats and mice follows a complex and highly reproducible pattern which has not previously been described in detail. In some regions, the callosal projection is associated with well defined cytoarchitectonic boundaries such as...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91192-6
更新日期：1981-06-15 00:00:00
abstract：:Orexin-A (OX-A) and -B (OX-B) peptides present in the hippocampus are considered to be exclusively contained in fibers arising from hypothalamus neurons, which were established as the only source of orexins (OXs). Because OX-A is known to exert excitatory actions in the hippocampus, we hypothesized that the level of O...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.06.075
更新日期：2006-09-13 00:00:00
abstract：:In the cat, cells of the superior colliculus (SC) and the tectofugal pathways of the visual system are highly selective for the direction of a moving visual stimulus. Deep layer units of SC in addition respond to auditory and somatosensory stimuli, but the proportion of such non-visual cells is usually found to be muc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90430-7
更新日期：1989-06-19 00:00:00
abstract：:The possible interference of nitric oxide (NO) in glucose metabolism was studied in activated astrocytes. Lipopolysaccharide (LPS) treatment triggered a NO-mediated increase in glucose consumption and lactate production, suggesting an enhanced rate of glycolysis. Active glycogen synthesis was also observed after LPS t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02877-9
更新日期：2002-07-26 00:00:00
abstract：:We examined for immediate and persistent changes in nAChRs in cerebral cortex, thalamus and striatum of male rats caused by prenatal exposure to nicotine from gestational day 3 to postnatal day 10 (PN10), and how such exposure affected the responses of adolescents to subsequent nicotine challenge. Receptor numbers wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.076
更新日期：2009-01-23 00:00:00
abstract：:Specific silver impregnation techniques for extracellular amyloid and intraneuronal neurofibrillary changes were used to examine the presubiculum in Alzheimer victims. Extended amyloid clouds in the absence of neurofibrillary changes were noted in the parvopyramidal layer of the presubiculum proper. The corresponding ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90164-9
更新日期：1989-08-07 00:00:00
abstract：:Studies of first (L1) and second (L2) language representation in the brain have not identified the timing and locations of neural regions involved in L1 and L2 processing. Magnetoencephalography offers high spatial and temporal resolution and can be employed to disentangle subtle timing and neural control differences ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.05.054
更新日期：2012-07-27 00:00:00
abstract：BACKGROUND:Perinatal brain injury in preterm infants is a major cause of neurological handicap. The role of the neurotrophin receptor p75 (p75(NTR)) in the pathogenesis and repair of neonatal excitotoxic brain injury is unknown. Depending on a complex interplay of neurotrophin signalling, p75(NTR) can, in addition to i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.095
更新日期：2010-10-08 00:00:00
abstract：:N-stearoyltyrosine (NsTyr), a synthesized anandamide (AEA) analogue, was evaluated for the first time in the present study for the neuroprotective effect in gerbils subjected to transient global cerebral ischemia reperfusion (IR). The extent of ischemia injury was assessed behaviorally by measuring neurological functi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.070
更新日期：2009-09-01 00:00:00
abstract：:The ependymocytes lining the central canal of the spinal cord in rats have prominent F-actin networks in the apical cytoplasm, exhibiting significant regional heterogeneity between differing spinal levels. It is not clear when and how this regional heterogeneity develops. We examined F-actin in the central canal durin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.08.045
更新日期：2008-11-06 00:00:00
abstract：:Systemic injections of the dopamine antagonist haloperidol (0.1-2.5 mg/kg) induced a dose dependent increase in Fos-like immunoreactivity (FLI) in the internal segment of the globus pallidus (GPi) and in the substantia nigra (SN) of cynomolgus monkeys. These findings are consistent with models of basal ganglia organiz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01550-4
更新日期：1999-07-24 00:00:00
abstract：:The subunit composition of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptors (AMPARs) is an important determinant of AMPAR biophysical properties and trafficking. To date, AMPAR subunit composition has been quantitatively evaluated only for the hippocampus, where different experimental approaches have yield...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.10.016
更新日期：2011-01-07 00:00:00
abstract：:The hippocampal formation is a highly plastic brain region that is sensitive to stress. It receives extensive noradrenergic projections, and noradrenaline is released in the hippocampus in response to stressor exposure. The hippocampus expresses particularly high levels of the alpha(1D) adrenergic receptor (ADR) and w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.084
更新日期：2010-04-06 00:00:00
abstract：:Regeneration of crushed axons in rat dorsal spinal roots was measured to investigate the transganglionic influence of an additional peripheral axonal injury. The right sciatic nerve was cut at the hip and the left sciatic nerve was left intact. One week later, both fifth lumbar dorsal roots were crushed and subsequent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91096-1
更新日期：1987-05-19 00:00:00
abstract：:Brain injury accelerates amyloid-β (Aβ) deposits and exacerbates Alzheimer's disease (AD). Accumulation of intracellular soluble Aβ impairs cognition prior to emergence of Aβ plaques. However, it is not known whether brain injury affects learning impairment attributable to intracellular soluble Aβ. We made a small inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.017
更新日期：2016-04-15 00:00:00
abstract：:Preferential uptake of dopamine occurred in mesocortical vs striatal synaptosomes obtained from acutely fighting isolated male ICR mice. Specifically, both Km and Vmax were significantly increased in the prefrontal cortex but not the caudate-putamen. The findings are similar to selective changes in mesocortical activi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90954-9
更新日期：1981-10-05 00:00:00
abstract：:As an approach to understanding why central neurons fail to regenerate, we have studied the response to proximal axotomy of transcallosal neurons of the cerebral cortex of the mouse. Anatomical studies have indicated only very slight regenerative responses by this population of cortical neurons. To further examine the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00100-5
更新日期：1997-05-02 00:00:00
abstract：:We have previously demonstrated that Fos immunoreactivity can be stimulated by KCl, forskolin or glutamate in cultured tyrosine hydroxylase-immunoreactive (TH-ir) hypothalamic neurons. The present study was performed to determine whether agents that regulate dopaminergic activity, particularly D1 and D2 receptor agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90711-0
更新日期：1994-07-18 00:00:00
abstract：:Horseradish peroxidase (HRP, 30% solution, 0.1-0.3 mul, 72 h) was injected unilaterally into the basal striatum (STR) and the dorsal ventricular ridge (DVR) of adult turtles (Chrysemys picta) in order to demonstrate the cells of origin of some afferents to these telencephalic structures. After selective STR injection,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90161-x
更新日期：1976-05-21 00:00:00
abstract：:The effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain edema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain. Brain edema was assessed by measurement of water and electrolyte contents of the brain. The results showed that pretreatme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90439-3
更新日期：1989-06-19 00:00:00
abstract：:The dipeptide N-acetylaspartylglutamate (NAAG) may be involved in the process of glutamatergic signaling by both acting at glutamate receptors and as a glutamate protransmitter. In the present study we determined the cellular localization and distribution of NAAG-like immunoreactivity (NAAG-LI) in normal human brain a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00784-1
更新日期：1997-10-24 00:00:00
abstract：:Bombesin (BN)- and substance P (SP)-containing neurons are found in the dorsal root ganglia, and project to the dorsal horn of the spinal cord. The present study was undertaken to determine if chronic deafferentation of the cat spinal cord would affect BN or SP receptors in the spinal cord. Ten and 30 days after a uni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90744-9
更新日期：1985-09-23 00:00:00
abstract：:The dynamics of regional cerebral blood flow and brain extracellular glucose were studied in the freely moving rat. These two variables were measured in the striatum during and following both mild tail pinch and restraint stress. Blood flow was monitored using a refinement of the hydrogen clearance technique that allo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90373-u
更新日期：1993-02-26 00:00:00
