Abstract:
:Brain injury accelerates amyloid-β (Aβ) deposits and exacerbates Alzheimer's disease (AD). Accumulation of intracellular soluble Aβ impairs cognition prior to emergence of Aβ plaques. However, it is not known whether brain injury affects learning impairment attributable to intracellular soluble Aβ. We made a small injury by injecting glutamate into the parietal cortex in 3xTg AD mice of 4-5 months old, at which age soluble Aβ is accumulated without Aβ deposits. The size of glutamate-induced lesion was significantly larger than that of saline-injected control lesion. We reduced the relative difficulty of Morris water maze (MWM) task by repeating it twice, so that saline-injected 3xTg mice could perform as well as wild-type control mice. Under this condition, glutamate-injected 3xTg mice exhibited learning deficits. DNA microarray analysis revealed that 3 genes are upregulated, with one gene downregulated, more than 2 folds in the hippocampus. These 4 genes do not appear to be involved directly in learning but may be a part of signal cascade triggered by glutamate-induced small injury. Hippocampal content of soluble Aβ1-42 was increased in the glutamate 3xTg group. Facilitation of large-conductance calcium-activated potassium (BK) channel accompanied learning recovery in the saline-control 3xTg group in agreement with our previous reports, in which learning deficits attributable to intracellular Aβ were alleviated by facilitating BK channels. However, BK channel remained suppressed in the glutamate 3xTg group. It is suggested that glutamate-induced injury worsens learning by enhancing the toxicity of soluble Aβ or increasing its content per se.
journal_name
Brain Resjournal_title
Brain researchauthors
Zou J,Wang M,Uchiumi O,Shui Y,Ishigaki Y,Liu X,Tajima N,Akai T,Iizuka H,Kato Ndoi
10.1016/j.brainres.2016.02.017subject
Has Abstractpub_date
2016-04-15 00:00:00pages
56-63eissn
0006-8993issn
1872-6240pii
S0006-8993(16)30060-9journal_volume
1637pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::This study presents a three-dimensional analysis of pallido-thalamic axons and axonal endings in the monkey (Macaca mulatta and M. irus). Injections of the anterograde tracer biocytin were made in the dorsal, associative region of the medial pallidum. Numerous axonal endings were observed within the pallidal territory...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00181-9
更新日期:1997-04-18 00:00:00
abstract::Preconditioning describes a variety of treatments that induce neurons to become more resistant to a subsequent ischemic insult. How preconditioned neurons adapt to subsequent ischemic stress is not fully understood, but is likely to involve multiple protective mechanisms. We hypothesized hypoxic preconditioning induce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.05.031
更新日期:2004-08-13 00:00:00
abstract::Tetramethylpyrazine (TMP) is one of the alkaloids contained in Ligustrazine which has been used in traditional Chinese medicine as an analgesic for injury and dysmenorrhea. ATP can elicit the sensation of pain. This study observed the effects of TMP on ATP-activated current (IATP) in rat DRG neurons. TMP (0.1-1 mM) co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.076
更新日期:2005-04-08 00:00:00
abstract::Inflammation and immunity play a crucial role in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Recently, a growing body of evidence indicates that Toll-like receptor (TLR) 4 is vital for inflammation and immunity. Therefore, this study aimed to detect the expression of TLR4 in the basilar...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.059
更新日期:2007-10-10 00:00:00
abstract::The pars externa (PE) system of the anterior olfactory nucleus (AON) in a primate, Callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (MOB) as revealed by tracing techniques. Focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90071-6
更新日期:1988-08-02 00:00:00
abstract::Previous electrophysiological experiments have shown that brain noradrenaline neurons in the locus ceruleus are activated by thermal cutaneous stimuli. In the present study a putative involvement of excitatory amino acids (EAA) in cutaneous LC activation was analyzed. Intraventricular administration of kynurenic acid ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91560-4
更新日期:1990-06-25 00:00:00
abstract::Chronic developmental exposure to ethanol can lead to a wide variety of teratogenic effects, which in humans are known as fetal alcohol spectrum disorders (FASD). Individuals affected by FASD may exhibit persistent impairments to cognitive functions such as learning, memory, and attention, which are highly dependent o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.10.005
更新日期:2018-01-01 00:00:00
abstract::The present study examined the influences of dopamine (DA) receptor stimulation on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of Sprague-Dawley rats, lesioned as neonates with 6-hydroxydopamine (6-OHDA). It has been proposed that the neonatal 6-OHDA-lesioned rat could se...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90305-3
更新日期:1989-10-23 00:00:00
abstract::The neuroprotective effects of N-stearoyl-L-tyrosine (NSTyr) on cognitive function and neuronal plasticity during chronic cerebral hypoperfusion (CCH) in rats were investigated. After induction of CCH, NSTyr was administered daily for 3 months intraperitoneally. Cognitive functions were evaluated by Morris water maze ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.037
更新日期:2010-04-14 00:00:00
abstract::Whole cell and single channel Ca2+ currents were compared for hippocampal neurons of normal and ethanol-tolerant long-sleep and short-sleep mice. The properties of these currents were equivalent for normal LS and SS mice. In contrast, the peak amplitude of the whole cell Ca2+ current increased significantly for neuron...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90044-n
更新日期:1993-07-02 00:00:00
abstract::Several studies have reported transient expression of tyrosine hydroxylase in a subpopulation of neurons in the bed nucleus of stria terminalis of preadolescent rats. The tyrosine hydroxylase immunoreactive (TH) neurons, which are of small to medium size and often display a typical bipolar configuration, are confined ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01175-7
更新日期:1996-01-08 00:00:00
abstract::Glycogen synthase kinase (GSK)-3beta and extracellular signal-regulated kinase (ERK) regulate several cellular signaling pathways in common, including embryonic development, cell differentiation and apoptosis. In this study, we investigated whether GSK-3beta inhibition is involved in ERK activation, which affects the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.018
更新日期:2007-12-01 00:00:00
abstract::Female rats were subjected to unilateral left or right, bilateral, or sham ablation of the cerebral cortex. Eight weeks after surgery, the rats were sacrificed by decapitation and spleen cells were grown in culture for 96 h in the presence or absence of the T-cell mitogen concanavalin A or the B-cell mitogen lipopolys...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90042-5
更新日期:1989-03-27 00:00:00
abstract::Melatonin is a hormone that mostly produced from the pineal gland, and it performs as a strong neuroprotectant to both neuron and glial cells against methamphetamine (METH)-induced neurotoxicity. Recently, it has been found that METH also damages the blood brain barrier (BBB) structure and function. However, the prote...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.08.045
更新日期:2016-11-01 00:00:00
abstract::In the course of studies on the responsiveness of mediobasal hypothalamic neurons to the iontophoretic application of cortisol, it was found that positive currents applied to a sodium chloride (1 M) barrel alone, but not to a choline chloride (1 M) barrel, frequently increased the firing of these neurons. Subsequently...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91091-0
更新日期:1983-08-22 00:00:00
abstract::The present study examined the effects of excitotoxins which activate distinct excitatory amino acid (EAA) receptor subtypes on the levels of Methionine-enkephalin-like immunoreactivity (ME-i.r.) in the striatum and globus pallidus, with a view to developing a model of the striatopallidal enkephalin deficit that preva...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90029-b
更新日期:1990-12-17 00:00:00
abstract::Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward currents with a decrease in membrane conductance at a holding potential...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91232-7
更新日期:1994-02-21 00:00:00
abstract::Recently we reported that chronic treatment with 17beta-estradiol (E2) or tamoxifen (TAM) regulates the ovariectomy-induced downregulation of the key molecules linked to hippocampal synaptic plasticity and signal transduction pathway. We now report modulation of the antiapoptotic (Bcl-2) and proapoptotic (Bax) protein...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.080
更新日期:2008-04-14 00:00:00
abstract::The endocannabinoid system is a promising therapeutic target in a wide variety of diseases. However, the non-desirable psychotropic effects of natural and synthetic cannabinoids have largely counteracted their clinical usefulness. These effects are mostly mediated by cannabinoid receptors of the CB(1) type, that exhib...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.05.098
更新日期:2009-08-04 00:00:00
abstract::Maternal cocaine abuse has several deleterious effects in the newborn, including perinatal asphyxia, hypoxia, and hypercapnia. We hypothesized that chronic cocaine exposure during development may alter cerebral blood flow (CBF) regulation. We studied 16 neonatal rabbits that had received cocaine (20 mg/kg, i.p. b.i.d....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00178-9
更新日期:1997-04-25 00:00:00
abstract::The results of a WGA-HRP and HRP study in the cat indicated that some neurons in the marginal zone (lamina I) of the caudal spinal trigeminal nucleus sent their axons contralaterally to the striatum; mainly to the dorsal part of the putamen, and additionally to the ventrolateral part of the caudate nucleus, at the ste...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90400-8
更新日期:1987-04-07 00:00:00
abstract::Stimulation of a region within the parvocellular medullary reticular formation (PcRF) that contains somas of premotor interneurons produces short latency inhibitory synaptic potentials (IPSPs) in cat trigeminal motoneurons. The present study was undertaken to determine whether glycinergic synapses are responsible for ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90818-g
更新日期:1991-12-20 00:00:00
abstract::The anesthetic-sedative barbiturate pentobarbital (PB) and the anticonvulsant barbiturate phenobarbital (PhB) were applied to mammalian spinal cord neurons in primary dissociated cell culture to assess their effects on: (1) postsynaptic GABA-responses; (2) paroxysmal activity produced by the convulsant bicuculline; (3...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)91179-3
更新日期:1981-03-23 00:00:00
abstract::Neurokinin A and B (NKA and NKB) and neuropeptide K (NPK) were recently isolated from porcine spinal cord and brain, and together with substance P (SP) considerably extend the list of tachykinin-like peptides present in the mammalian nervous system. In order to investigate the distribution of tachykinins in the centra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91514-3
更新日期:1986-12-10 00:00:00
abstract::The subfornical organ (SFO), a neuroendocrine structure implicated in saltwater homeostasis, contains secretory structures histochemically similar to those in the neurohypophysis. Because of these morphological similarities, we compared levels of vasopressin (vp) in the SFO area and the adjacent hippocampal commissure...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90458-4
更新日期:1978-01-27 00:00:00
abstract::(1) Synaptic transmission was studied in isolated transverse hippocampal slices from guinea pigs. Extracellular evoked potentials were recorded in the region CA1. (2) Changing the normal perfusion solution (containing 2 mM Ca2+) to calcium-free Ringer abolished synaptic transmission which was again restored by adding ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91327-x
更新日期:1980-07-21 00:00:00
abstract::Non-peptide receptor ligands with differential affinity for the angiotensin II-1 (AII-1) receptor (EXP3312, EXP3880) or the AII-2 receptor (PD123177) and an angiotensin converting enzyme (ACE) inhibitor captopril were evaluated for the ability to protect against a renin-induced performance deficit in a passive avoidan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91599-v
更新日期:1991-10-11 00:00:00
abstract::The effect of maternal hyperthermia on the developmental state of newborn guinea pig brains has been studied. Mean litter size and mean body weights of young from control and experimental mothers did not differ. Mean brain weight of young from control mothers (2.72 +/- 0.02 g) was larger than that from experimental mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90306-7
更新日期:1984-06-01 00:00:00
abstract::Superior colliculus cells that respond to a given sensory input (visual or auditory) were influenced by the presence of a stimulus in the other modality. This is a form of sensory-sensory integration which has previously been thought to be involved in initiating the orientation of receptor organs in response to such c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90253-8
更新日期:1987-09-08 00:00:00
abstract::An extract of fetal calf striated muscle was found to support the survival, growth and differentiation of chick ciliary ganglion neurons in dissociated cell culture. The active material was precipitated in a single fraction by 35-60% ammonium sulfate. When this active fraction was passed over a concanavalin A-Sepharos...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90229-9
更新日期:1985-03-01 00:00:00