Abstract：
:Inflammation and immunity play a crucial role in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Recently, a growing body of evidence indicates that Toll-like receptor (TLR) 4 is vital for inflammation and immunity. Therefore, this study aimed to detect the expression of TLR4 in the basilar artery in a rabbit SAH model and to clarify the potential role of TLR4 in cerebral vasospasm. A total of 48 rabbits were randomly divided into four groups: control group; day 3, day 5, and day 7 groups. Day 3, day 5, and day 7 groups were all SAH groups. The animals in day 3, day 5 and day 7 groups were subjected to injection of autologous blood into cisterna magna twice on day 0 and day 2 and were killed on days 3, 5, and 7, respectively. Cross-sectional area of basilar artery was measured and the TLR4 expression was assessed by immunohistochemistry and Western blot analysis. The basilar arteries exhibited vasospasm after SAH and became more severe on day 3 and 5. The elevated expression of TLR4 was detected after SAH and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhou ML,Wu W,Ding YS,Zhang FF,Hang CH,Wang HD,Cheng HL,Yin HX,Shi JXdoi
10.1016/j.brainres.2007.07.059subject
Has Abstractpub_date
2007-10-10 00:00:00pages
110-6eissn
0006-8993issn
1872-6240pii
S0006-8993(07)01754-4journal_volume
1173pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Multiple retrograde fluorescent tracing was employed to investigate the organization of the rat entopeduncular nucleus projections to the lateral habenula, ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The results indicate that neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90064-0
更新日期：1981-04-27 00:00:00
abstract：:Rats were trained to lever-press for lateral hypothalamic electrical stimulation, and tested following ventral tegmental microinjections of morphine, delta ([D-Pen2,D-Pen5]enkephalin: DPDPE), or kappa (U-50, 488H) receptor agonists or saline. Across the range of effective stimulation frequencies, morphine (8 nmol) and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90821-3
更新日期：1987-10-13 00:00:00
abstract：:Clozapine therapy has been associated with a high degree of urinary disturbances. The purpose of this study is to examine the effect of clozapine on urodynamic parameters and on the activity of the external urethral sphincter in anesthetized rats. Single cystometrograms (CMG) were performed on urethane-anesthetized fe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02352-6
更新日期：2001-05-18 00:00:00
abstract：:The functional organization of projections from the cerebellar subcortical nuclei to the motor cortex through the nucleus ventralis lateralis (VL) of the thalamus was studied using tungsten microelectrodes for stimulation and recordings in acute and chronic cats. The following results were obtained. (1) Microstimulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90510-7
更新日期：1975-11-07 00:00:00
abstract：:GM1 ganglioside injections (i.p.) reduce amphetamine-induced asymmetric rotation in rats 48 h after a partial unilateral transection of the nigrostriatal pathway. We found that this reduction was maximal when rats received their first GM1 injection within 2 h after surgery. Rats injected 4-12 h after surgery, or rats ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90871-1
更新日期：1986-07-09 00:00:00
abstract：:The objective was to determine if corticopetal basal forebrain neurons could co-synthesize different transmitters. Histochemical labeling of a molecular marker of connectivity (wheat germ agglutinin lectin-bound horseradish peroxidase [HRP]; axonal uptake and retrograde transport from neocortex) and immunohistochemica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90099-1
更新日期：1989-07-03 00:00:00
abstract：:Decreases in the extracellular calcium concentration ([Ca2+]o), induced by tetanization of the Schaffer collaterals in rat hippocampal slices, were measured by means of Ca2+-sensitive microelectrodes. The amount of long term potentiation (LTP) of the evoked field potentials, induced by this tetanus, was determined. A ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90798-6
更新日期：1988-06-28 00:00:00
abstract：:The interpeduncular nucleus (IPN) was stimulated electrically while single-cell activity was recorded in the nucleus raphe magnus (NRM) of rats under pentobarbital anesthesia. Two classes of NRM cell were examined, those inhibited (off-cells) and those excited (on-cells) by noxious mechanical skin stimulation. Off-cel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91476-w
更新日期：1990-07-09 00:00:00
abstract：:Spontaneous and drug-induced interictal and post-ictal locomotor behavior of rats was investigated following electrical 'kindling' of different limbic structures at 3 brain sites which differ in the relative amount of innervation from dopamine cells of the ventral tegmentum: nucleus accumbens (N.Acc.), amygdala (AMYG)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91385-x
更新日期：1985-02-04 00:00:00
abstract：:Repeated intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and angiotensin III (AIII) induced dipsogenic tachyphylaxis in the Sprague-Dawley rat. AIII caused a rapid suppression of drinking, whereas AII showed a progressive decline of water consumption with repeated injections. Tachyphylaxis due ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90010-8
更新日期：1988-06-14 00:00:00
abstract：:The monoclonal antibody E/C8 was originally generated against chicken dorsal root ganglia. The antigen detected by E/C8, NAPA-73, is an intermediate filament-associated protein. NAPA-73 was shown to be one of the earliest neuronal markers to appear during development since it appears in some neuronal precursor cells o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91289-3
更新日期：1987-09-22 00:00:00
abstract：:Abnormally hyperphosphorylated tau is the major protein component of neurofibrillary tangles, the characteristic lesion of Alzheimer's disease (AD). Protein phosphatases (PP) type 1 (PP-1), type 2A (PP-2A) and type 2B (PP-2B) appear to be involved in the regulation of tau phosphorylation. The incidence of neurofibrill...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00904-3
更新日期：1996-11-25 00:00:00
abstract：:The analgesia induced by 30-s footshock (1 mA) is enhanced and attenuated by decreasing and increasing the extraneuronal availability of serotonin (5-HT), respectively. In the present work we have shown the effect to be mediated by spinal 5-HT systems as the response was increased by depletion of spinal but not brain ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90448-6
更新日期：1982-04-15 00:00:00
abstract：:Previous studies have found that the primary change in the brain of chronic alcoholics is a selective loss of white matter in cerebral hemispheres. It is unknown whether the loss of white matter is due to alcohol-induced degeneration of axons in white matter, and this hypothesis has never been tested. We used a newly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.035
更新日期：2004-12-17 00:00:00
abstract：:Enkephalin-like immunoreactive nerve fibers in the celiac ganglion of guinea pigs were characterized by a high population of large granular vesicles mixed with small clear vesicles. The immunoreactive material is confined to the large granular vesicles. The immunoreactive nerve fibers formed many axo-dendritic as well...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90987-8
更新日期：1982-12-02 00:00:00
abstract：:An in vitro preparation of the medulla oblongata of the rat was used to examine the responses to reducing pH, at constant CO2, of neurons in several identified nuclei. Neurons in an area close to the ventral surface, which is thought to be the location of pH-sensitive central respiratory chemoreceptors, did not respon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90300-1
更新日期：1983-07-25 00:00:00
abstract：:Amino acid uptake by slices of brain is greatly diminished by incubation of the slices in glucose-free media. Uptake can be restored by the addition of a number of substrates, e.g., lactate, citrate, or oxaloacetate. The mixture of succinate, malate, and pyruvate (SMP, 20, 5, and mM) restored amino acid uptake better ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90524-8
更新日期：1977-08-12 00:00:00
abstract：:Antisense oligodeoxynucleotide (AS ODN) probes directed against the alpha-subunit of different G-proteins have been used to differentiate feeding responses in rats elicited by different opioid agonists, including morphine, beta-endorphin and dynorphin. Furthermore, antisense probes directed against G(o)alpha, but not ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03361-9
更新日期：2002-11-15 00:00:00
abstract：:In primary neuron cultures obtained from ventral mesencephalon of mouse fetuses, approximately 10-30% of the neurons were dopaminergic, as demonstrated by a rapid glyoxylic acid histofluorescence procedure, and another 10-30% were GABAergic as demonstrated by autoradiography. Resting membrane potentials averaged -58 m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90024-7
更新日期：1988-04-01 00:00:00
abstract：:Branches of the facial nerve were transected in newborn mice, resulting in paralysis of whisking of the mystacial vibrissae. After maturation, the brains were examined in Nissl preparations for alterations in the barrel field of the primary somatosensory cortex. There were no evident changes as a result of this interv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90141-0
更新日期：1984-11-26 00:00:00
abstract：:Immunohistochemical expression of the doublecortin (DCX) gene product was investigated in cerebral cortices from 33 normal developing human, aged 9 gestational weeks (GW) to 29 years, and from 26 patients with various neuronal migration disorders, aged 19 GW to 34 years. DCX immunoreactivity was detected predominantly...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02099-0
更新日期：2000-04-28 00:00:00
abstract：:The onset of the daily wheel running bout precedes dark onset by several hours in the early runner genetic variant of mice. Here, we test the hypothesis that timed daily administration of a melatonin agonist, ramelteon, or a benzodiazepine, triazolam, normalizes the timing of daily wheel-running rhythms in early runne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.103
更新日期：2009-11-03 00:00:00
abstract：:Cholecystokinins in rat cerebral cortex were studied by radioimmunoassay using an antiserum specific for the COOH-terminus of CCK8. Total concentrations of immunoreactive CCK in cortex were 3-4 fold higher than in jejunum. Rat cerebral CCK was purified by immuno-affinity adsorption to the IgG fraction of CCK antisera ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90564-8
更新日期：1980-04-21 00:00:00
abstract：:The presence of calretinin and calbindin immunoreactivity is studied in the retina of larval and adult lamprey and their respective distributions are compared. Calretinin distribution is also studied in the retina of transforming stages. Western blot analysis in brain extracts showed a 29-kDa band with both polyclonal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.11.014
更新日期：2006-01-12 00:00:00
abstract：:Bombesin (BN)- and substance P (SP)-containing neurons are found in the dorsal root ganglia, and project to the dorsal horn of the spinal cord. The present study was undertaken to determine if chronic deafferentation of the cat spinal cord would affect BN or SP receptors in the spinal cord. Ten and 30 days after a uni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90744-9
更新日期：1985-09-23 00:00:00
abstract：:In over half a century numerous studies have demonstrated that different odorants produce individually different spatial patterns of neural receptor activity on the olfactory mucosa. However, the thought that these differential activity patterns could be the neural code underlying olfactory perception has not been tes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02512-5
更新日期：2003-08-15 00:00:00
abstract：:We have previously shown that systemic administration of ondansetron, a selective serotonin type-3 (5-HT3) receptor antagonist, attenuates cholecystokinin (CCK)-induced suppression of food intake. The exact location of 5-HT3 receptors mediating this action is not clear and may involve hindbrain 5-HT3 receptors. In thi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.058
更新日期：2006-08-04 00:00:00
abstract：:Previous work has demonstrated that 3 pharmacologically and neuroanatomically distinct analgesia systems can be sequentially activated by increasing numbers of transcutaneous tail-shock. To date, the categorization of the early (after 2 tail-shocks) and late (after 80-100 tail-shocks) analgesias as opiate-mediated has...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90310-6
更新日期：1992-06-05 00:00:00
abstract：:We have previously raised a monoclonal antibody (69A1) which recognises a cell-surface antigen expressed on rat cerebellar neurons both in culture and in tissue sections of the developing cerebellum prior to postnatal day 17. In our current study we have undertaken a detailed analysis of the loss of labelling from the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90087-8
更新日期：1986-09-01 00:00:00
abstract：:The present study was undertaken to examine the differential effect of estrogen (E) on the expression of tyrosine hydroxylase (TH) in the substantia nigra compacta (SNc) and in two subdivisions of the ventral tegmental area in ovariectomized (ovx) and ovx plus estradiol benzoate (ovx+E)-treated female rats. Cell count...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02323-4
更新日期：2000-06-23 00:00:00
