Abstract:
:The analgesia induced by 30-s footshock (1 mA) is enhanced and attenuated by decreasing and increasing the extraneuronal availability of serotonin (5-HT), respectively. In the present work we have shown the effect to be mediated by spinal 5-HT systems as the response was increased by depletion of spinal but not brain 5-HT following injection of 5,7-dihydroxytryptamine into the spinal cord or raphe magnus. Injection of 5,7-DHT into the medial raphe which depleted brain but not spinal 5-HT was without effect.
journal_name
Brain Resjournal_title
Brain researchauthors
Hutson PH,Tricklebank MD,Curzon Gdoi
10.1016/0006-8993(82)90448-6subject
Has Abstractpub_date
1982-04-15 00:00:00pages
367-72issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(82)90448-6journal_volume
237pub_type
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