Enhancement of footshock-induced analgesia by spinal 5,7-dihydroxytryptamine lesions.

Abstract:

:The analgesia induced by 30-s footshock (1 mA) is enhanced and attenuated by decreasing and increasing the extraneuronal availability of serotonin (5-HT), respectively. In the present work we have shown the effect to be mediated by spinal 5-HT systems as the response was increased by depletion of spinal but not brain 5-HT following injection of 5,7-dihydroxytryptamine into the spinal cord or raphe magnus. Injection of 5,7-DHT into the medial raphe which depleted brain but not spinal 5-HT was without effect.

journal_name

Brain Res

journal_title

Brain research

authors

Hutson PH,Tricklebank MD,Curzon G

doi

10.1016/0006-8993(82)90448-6

subject

Has Abstract

pub_date

1982-04-15 00:00:00

pages

367-72

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(82)90448-6

journal_volume

237

pub_type

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