Myelinated nerve fibres in the subcortical white matter of cerebral hemispheres are preserved in alcoholic subjects.

abstract：:Glucocorticoids (GC) provide neuroprotection and early recovery after spinal cord injury (SCI). While several mechanisms were proposed to account for these effects, limited information exists regarding GC actions in sensory areas of the spinal cord. Presently, we studied the time course of Fos expression, and reduced ...

journal_title：Brain research

authors： González S,Labombarda F,Gonzalez Deniselle MC,Saravia FE,Roig P,De Nicola AF

更新日期：2001-09-07 00:00:00

abstract：:Amyloid-beta protein (A beta) deposition in the cerebral vascular walls is one of the key features of Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D). A beta(1-40) carrying the 'Dutch' mutation (HCHWA-D A beta(1-40)) induces pronounced degeneration of cultured human brain p...

journal_title：Brain research

authors： Rensink AA,Verbeek MM,Otte-Höller I,ten Donkelaar HT,de Waal RM,Kremer B

更新日期：2002-10-11 00:00:00

abstract：:Snake venom kappa-neurotoxins are selective antagonists of nicotinic acetylcholine responses in avian, murine and bovine neurons, and have been used as probes for functionally defined vertebrate neuronal nicotinic receptors. The actions of kappa-bungarotoxin, a kappa-neurotoxin, have now been examined at a central inv...

journal_title：Brain research

authors： Pinnock RD,Lummis SC,Chiappinelli VA,Sattelle DB

更新日期：1988-08-16 00:00:00

abstract：:Whole-cell patch recordings of neurons in the rostral (gustatory) nucleus tractus solitarius (rNTS) were performed in a brain slice preparation from rat medulla. Neural responses to brief applications (10-45 s) of substance P (SP), via a constant superfusion apparatus, were recorded. SP transiently depolarized 80 of 1...

journal_title：Brain research

authors： King MS,Wang L,Bradley RM

更新日期：1993-08-13 00:00:00

abstract：:Somatostatin neuronal perikarya and their processes, presumably dendrites, in the periventricular nucleus of the rat hypothalamus and terminals in the median eminence were observed by electron microscopic immunohistochemistry. Neuronal perikarya and processes contained immunoreactive dense granules (100-120 nm in diam...

journal_title：Brain research

authors： Ibata Y,Obata HL,Kubo S,Fukui K,Okamura H,Ishigami T,Imagawa K,Sin S

更新日期：1983-01-10 00:00:00

abstract：:The distribution of neurocalcin-immunoreactive (NC-ir) primary sensory neurons was examined in the trigeminal ganglion (TG), mesencephalic trigeminal tract nucleus (Mes5) and intraoral structures. NC-ir primary sensory neurons were located in the TG but not the Mes5. The coexpression study demonstrated that virtually ...

journal_title：Brain research

authors： Ichikawa H,Hidaka H,Sugimoto T

更新日期：2000-05-02 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are readily accessible multipotent mesenchymal stem cells and are known to secrete multiple growth factors, and thereby to have cytoprotective effects in various injury models. In the present study, the authors investigated the neuroprotective effect of ASCs in an intracerebral hemorr...

journal_title：Brain research

authors： Kim JM,Lee ST,Chu K,Jung KH,Song EC,Kim SJ,Sinn DI,Kim JH,Park DK,Kang KM,Hyung Hong N,Park HK,Won CH,Kim KH,Kim M,Kun Lee S,Roh JK

更新日期：2007-12-05 00:00:00

abstract：:We examined the effect of prostaglandin (PG)E2 on the sleep-wake activity and on body temperature by microinjecting PGE2 into the preoptic area of rats that had been chronically implanted with guide cannulae and electrodes for the recordings of electroencephalogram and electromyogram. PGE2 at doses of 2.5 X 10(-13), 2...

journal_title：Brain research

authors： Matsumura H,Goh Y,Ueno R,Sakai T,Hayaishi O

更新日期：1988-03-22 00:00:00

abstract：:The brainstem nucleus, locus coeruleus (LC), is the major, if not the sole, source of noradrenergic (NE) innervation of the telencephalon. It is generally held that LC neurons project diffusely to the entire neuroaxis and this had been the basis for theories that postulate 'general' functions (sleep, attention, learni...

journal_title：Brain research

authors： Shipley MT,Halloran FJ,de la Torre J

更新日期：1985-03-11 00:00:00

abstract：:The distribution of substance P (SP) immunoreactivity in the spinal nucleus of the rat trigeminal nerve and in the skin of the lower lip was examined following (a) unilateral electrolytic lesions of the trigeminal ganglion, (b) trigeminal rhizotomy, and (c) unilateral interruption of the mental nerve, the sensory bran...

journal_title：Brain research

authors： Cuello AC,Del Fiacco M,Paxinos G

更新日期：1978-09-08 00:00:00

abstract：:Stimulation frequency thresholds for lateral hypothalamic self-stimulation were monitored for 3 weeks following the induction of diabetes with streptozotocin (STZ). In each of the 3 weeks following STZ treatment, thresholds of diabetic rats were significantly lower than their pre-STZ baseline while thresholds of contr...

journal_title：Brain research

authors： Carr KD

更新日期：1994-11-21 00:00:00

abstract：:In vitro quantitative autoradiography of high-affinity [3H]desmethylimipramine (DMI) binding sites was performed on 24 human brains postmortem. Highest densities of binding sites were found in portions of the amygdala, the granular layer of the dentate gyrus, the pyramidal layer of CA4. Next, in descending order were ...

journal_title：Brain research

authors： Gross-Isseroff R,Israeli M,Biegon A

更新日期：1988-07-19 00:00:00

abstract：:The glutamate analogue 2-amino-4-phosphonobutyric acid (AP4) is a potent antagonist at several synapses where an excitatory amino acid appears to be the neurotransmitter. Previous studies identified a Cl-/Ca2+ dependent [3H]glutamate binding site in synaptic plasma membrane (SPM) preparations that was also labeled by ...

journal_title：Brain research

authors： Bridges RJ,Hearn TJ,Monaghan DT,Cotman CW

更新日期：1986-06-04 00:00:00

abstract：:Fos-like immunoreactivity (FLI) can indicate the location of neurons activated following expression of conditioned taste aversion (CTA). After one conditioning trial FLI has been identified in the intermediate nucleus of the solitary tract (iNTS) with little expression in other brain regions. The present study assesse...

journal_title：Brain research

authors： Navarro M,Spray KJ,Cubero I,Thiele TE,Bernstein IL

更新日期：2000-12-29 00:00:00

abstract：:Mammalian vestibular type I hair cells (VIHCs) are innervated by an afferent synaptic calyx which contains vesicles and is immunoreactive for GABA. We describe here the effects of GABA on electrophysiological properties and on cytosolic free-calcium levels ([Ca2+]i) of VIHCs isolated from guinea-pig ampullae. Whole-ce...

journal_title：Brain research

authors： Lapeyre PN,Kolston PJ,Ashmore JF

更新日期：1993-04-23 00:00:00

abstract：:The effects of adenosine on the voltage-sensitive delayed-rectifier K+ (IK) currents and hyperpolarization-activated cationic inward current (Ih) were studied in cultured frog melanotrophs using the whole-cell configuration of the patch-clamp technique. The A1 receptor agonist R-N6-phenylisopropyl-adenosine (R-PIA; 50...

journal_title：Brain research

authors： Mei YA,Soriani O,Castel H,Vaudry H,Cazin L

更新日期：1998-05-18 00:00:00

abstract：:Calcium accumulation and neuronal injury of rat cortical cell cultures in vitro were examined following oxygen deprivation under conditions of normal and low glucose. 45Ca2+ uptake and lactate dehydrogenase (LDH) release, measured at 12 and 24 h after oxygen deprivation, were significantly elevated in cultures exposed...

journal_title：Brain research

authors： Birrell GJ,Marcoux FW

更新日期：1993-04-02 00:00:00

abstract：:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes a disruption of nigrostriatal dopaminergic function which resembles parkinsonism. On the cellular level, the disruption involves a Ca2+ independent release of dopamine, depletion of nigral and striatal dopamine, and the death of dopaminergic neurons. We have p...

journal_title：Brain research

authors： Wilson JA,Lau YS,Gleeson JG,Wilson JS

更新日期：1991-02-15 00:00:00

abstract：:In this research, we investigated striatal neurogenesis in 3-, 6-, 12-, and 18-month-old rats after cerebral ischemic injury. All rats were subjected to a 20-min middle cerebral artery occlusion (MCAO), given 5'-bromodeoxyuridine (BrdU, 30 mg/kg, i.p.) once daily during days 4-7 and sacrificed 2 weeks after MCAO. Neur...

journal_title：Brain research

authors： Chen Y,Sun FY

更新日期：2007-08-29 00:00:00

abstract：:In this study, we examined the immunohistochemical occurrence and distribution of glial cell line-derived neurotrophic factor (GDNF) in autoptic specimens of normal human hippocampus at different ages, from 22 weeks of gestation (w.g.) to adult life. Two different anti-GDNF polyclonal antibodies were used. Western blo...

journal_title：Brain research

authors： Pina Serra M,Quartu M,Ambu R,Follesa P,Del Fiacco M

更新日期：2002-02-22 00:00:00

abstract：:The addition of L-glutamic acid (Glu) alone, both Glu and glycine (Gly) or Glu/Gly/spermidine (SPD) was effective in potentiating [3H]5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding before equilibrium to an ion channel associated with the N-methyl-D-aspartate (NMDA) receptor complex in b...

journal_title：Brain research

authors： Yoneda Y,Enomoto R,Ogita K

更新日期：1994-02-14 00:00:00

abstract：:Large bilateral aspiration lesions of the hippocampus had no significant effect on septal kindling, whereas large bilateral DC lesions of the pyriform lobe resulted in a small but significant increase in the number of septal stimulations required to complete kindling. Bilateral aspiration lesions of the dorsal hippoca...

journal_title：Brain research

authors： Racine RJ,Paxinos G,Mosher JM,Kairiss EW

更新日期：1988-06-28 00:00:00

abstract：:Large neuronal perikarya isolated in bulk fractions from adult bovine ventral spinal cord and examined by electron microscopy have discontinuities in their plasma membrane. A systematic investigation of the possible causes of the membrane defects indicates that the act of mechanical dissociation of the neurons from th...

journal_title：Brain research

authors： Hester S,Capps-Covey P,McIlwain DL

更新日期：1978-12-22 00:00:00

abstract：:The effects of systemically administered interleukin-1beta (1.0 microg) on in vivo variations of monoamines was assessed in several brain regions. Administration of the cytokine provoked a modest increase of extracellular 5-HIAA and HVA from the nucleus accumbens, and 5-HIAA from the hippocampus. Following mild neurog...

journal_title：Brain research

authors： Merali Z,Lacosta S,Anisman H

更新日期：1997-07-04 00:00:00

abstract：:Cell cultures of olfactory bulb from 2-3-day-old rats were used to evaluate 6 antimitotic drugs for their effects on neuronal survival. In cultures grown in medium without drugs for 7 days, neurons died as a layer of non-neuronal cells proliferated. A series of experiments were performed to determine dilutions and exp...

journal_title：Brain research

authors： Burry RW

更新日期：1983-02-21 00:00:00

abstract：:Diabetic retinopathy is the leading cause of acquired blindness in working-age individuals. Recent work has revealed that neurodegeneration occurs earlier than vascular insult and that distal optic nerve damage precedes retinal degeneration and vascular insult. Since we have shown that optic nerve degeneration is redu...

journal_title：Brain research

authors： Mendonça HR,Carvalho JNA,Abreu CA,Mariano de Souza Aguiar Dos Santos D,Carvalho JR,Marques SA,da Costa Calaza K,Martinez AMB

更新日期：2018-12-01 00:00:00

abstract：:This study describes the development and establishment of pure cerebrovascular smooth muscle cells derived from dissociated cells of microvessels obtained from brains of rats. The cultured and propagated vascular smooth muscle cells display histochemical and ultrastructural characteristics of smooth muscle cells consi...

journal_title：Brain research

authors： Spatz M,Dodson RF,Bembry J

更新日期：1983-12-05 00:00:00

abstract：:Loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of Parkinson's disease (PD) and results in a partial deafferentation to the striatum. Since deafferentation is known to induce transynaptic atrophy of postsynaptic cells, we examined by Golgi impregnation the morph...

journal_title：Brain research

authors： McNeill TH,Brown SA,Rafols JA,Shoulson I

更新日期：1988-07-05 00:00:00

abstract：:The avian pineal exhibits a daily rhythm in the synthesis and secretion of the hormone, melatonin, which is involved in maintaining temporal order within the circadian system of some species. The pineal is richly innervated by sympathetic nerves which originate in the superior cervical ganglia (SCG) and, in the chicke...

journal_title：Brain research

authors： Barrett RK,Underwood H

更新日期：1992-01-13 00:00:00

abstract：:Painful experience is a complex entity made up of sensory, affective, motivational and cognitive dimensions. The neural mechanisms involved in pain perception acts in a serial and a parallel way, discriminating and locating the original stimulus and also integrating the affective feeling, involved in a special situati...

journal_title：Brain research

authors： Almeida TF,Roizenblatt S,Tufik S

更新日期：2004-03-12 00:00:00