Abstract：
:Adipose-derived stem cells (ASCs) are readily accessible multipotent mesenchymal stem cells and are known to secrete multiple growth factors, and thereby to have cytoprotective effects in various injury models. In the present study, the authors investigated the neuroprotective effect of ASCs in an intracerebral hemorrhage (ICH) model. ICH was induced via the stereotaxic infusion of collagenase, and human ASCs (three million cells per animal) isolated from human fresh fat tissue, were intravenously administered at 24 h post-ICH induction. Acute brain inflammation markers, namely, cell numbers positively stained for terminal transferase dUTP nick end labeling (TUNEL), myeloperoxidase (MPO), or OX-42, and brain water content were checked at 3 days post-ICH. In addition, the authors quantified brain degeneration by measuring hemispheric atrophy and perihematomal glial thickness at 6 weeks post-ICH, and determined modified limb placing behavioral scores weekly over 5 weeks post-ICH. The results showed that brain water content, TUNEL+, and MPO+ cell numbers were significantly reduced in the ASC-transplanted rats. ASC transplantation attenuated neurological deficits from 4 to 5 weeks post-ICH, and reduced both the brain atrophy and the glial proliferation at 6 weeks. Transplanted ASCs were found to densely populate perihematomal areas at 6 weeks, and to express endothelial markers (von Willebrand factor and endothelial barrier antigen), but not neuronal or glial markers. In summary, ASCs transplantation in the ICH model reduced both acute cerebral inflammation and chronic brain degeneration, and promoted long-term functional recovery.
journal_name
Brain Resjournal_title
Brain researchauthors
Kim JM,Lee ST,Chu K,Jung KH,Song EC,Kim SJ,Sinn DI,Kim JH,Park DK,Kang KM,Hyung Hong N,Park HK,Won CH,Kim KH,Kim M,Kun Lee S,Roh JKdoi
10.1016/j.brainres.2007.09.005subject
Has Abstractpub_date
2007-12-05 00:00:00pages
43-50eissn
0006-8993issn
1872-6240pii
S0006-8993(07)02079-3journal_volume
1183pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:We examined how adjective ordering is used in language comprehension by crossing order preference and concreteness in phrases consisting of two adjectives and a noun. We used both more typical phrases in which the preferred order has a concrete second adjective ("exhaustive hardback encyclopedia") and those with a con...
journal_title：Brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brainres.2012.07.050
更新日期：2012-09-26 00:00:00
abstract：:The present electric shock (ES) schedule followed in these experiments produced different functional changes in endogenous putative opioid agonist- and antagonist-type receptors, depending on the type of receptor: the amount of antagonist binding was increased by ES application, while the amount of agonist binding was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91155-2
更新日期：1985-09-16 00:00:00
abstract：:The release of adipokinetic hormones from the neurosecretory cells within the glandular lobe of the corpus cardiacum (CC) of locusts is under the synaptic control of axons within the nervi corporis cardiaca II (NCC II). This synapse has been shown to be aminergic with the transmitter tentatively identified as octopami...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91242-8
更新日期：1983-01-03 00:00:00
abstract：:Inflammation and immunity play a crucial role in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Recently, a growing body of evidence indicates that Toll-like receptor (TLR) 4 is vital for inflammation and immunity. Therefore, this study aimed to detect the expression of TLR4 in the basilar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.059
更新日期：2007-10-10 00:00:00
abstract：:We investigated the effect of beta-estradiol (E2) on synaptogenesis in the hippocampus using organotypic hippocampal slice cultures and subregional hippocampal neuron cultures. E2 increased the expression of PSD95, a postsynaptic marker, specifically in stratum lucidum of Cornu Ammonis 3 (CA3SL) in cultured hippocampa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.02.093
更新日期：2007-05-30 00:00:00
abstract：:Intracellular recordings from CA3b/c neurons in rat hippocampal slices showed that reduction of the extracellular Cl- concentration from 136 to 53 mM produced a positive (+10 mV) shift in the reversal potential of GABAergic inhibitory postsynaptic potentials (IPSPs). This shift was not significantly different from the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91068-2
更新日期：1988-03-29 00:00:00
abstract：:The possibility of a functional relationship between noradrenaline and neurohypophyseal peptides in the control of cardiovascular function in the nucleus tractus solitarius of rats has been investigated. The hypotensive response to microinjections of noradrenaline (20 nmol) was abolished by simultaneous (but not prior...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90936-x
更新日期：1987-10-06 00:00:00
abstract：:Data are presented which show a different pattern of dopamine and noradrenaline utilization in terminal regions of the A9 and A10 dopaminergic systems and in terminal regions of the dorsal noradrenergic bundle after electrical stimulation of the ventral tegmental area and an adjacent area. At the sites of the electrod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90505-x
更新日期：1983-06-06 00:00:00
abstract：:The cerebellum and inferior olive of adult homozygous leaner mutant mice (tgIa/tgIa) were examined using anti-vitamin D-dependent calcium binding protein immunohistochemistry, and Nissl staining. The immunohistochemical staining revealed that cerebellar Purkinje cell loss in leaner is restricted to alternating saggita...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(09)90014-2
更新日期：1994-09-26 00:00:00
abstract：:This study is focused to learn about the cellular localization of transcription factors binding to the cAMP response element-CREBs-in the brain of normal rats and in animals subjected to excitotoxic cell damage. For this purpose, CREB-1 and CREB-2 immunoreactivity is examined in the developing and adult rat brain unde...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01527-2
更新日期：1996-03-11 00:00:00
abstract：:The retrograde transport of fluorescent substances was used in order to investigate divergent axon collaterals of neurons in the nucleus prepositus hypoglossi (Ph). Fast blue (FB) was injected into the flocculus, paraflocculus and/or the vermis, while nuclear yellow (NY) was injected into the oculomotor nucleus alone ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90150-0
更新日期：1982-08-19 00:00:00
abstract：:Cells in layers II-III or VI were activated by microdrop application of acetylcholine (ACh), while monitoring the intracellular response of layer V pyramidal cells. This enabled the tracing of functional connections between the cells of layers II-III or VI with those of layer V. ACh activation of layer II-III or VI ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90811-m
更新日期：1992-03-06 00:00:00
abstract：:About 45% of the serotonergic raphe neurons are reported to express nerve growth factor (NGF) receptors. We therefore investigated whether selective serotonergic lesions of the median or dorsal raphe nuclei are associated with changes in NGF protein levels of the brain and whether the loss of serotonergic function alt...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02611-7
更新日期：2001-07-13 00:00:00
abstract：:The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 micrograms free base) on 5-HT1B binding sites labeled with S-CM-G-[125I]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surger...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91452-x
更新日期：1993-10-01 00:00:00
abstract：:By application of the anterograde transport technique of Phaseolus vulgaris leuco-agglutinin the descending autonomic projection of the paraventricular hypothalamic nucleus was investigated. The Phaseolus lectin technique allowed the detection of the cells of origin in the paraventricular PVN, the precise position of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90554-2
更新日期：1985-03-11 00:00:00
abstract：:The involvement of striatal cholinergic neurons in the release of dopamine (DA) elicited by the mu-opioid receptor agonist DAGO ([D-Ala2, NMePhe4-Gly5(ol)]enkephalin) was explored. The striatal release of DA was measured by microdialysis in rats anesthetized with chloral hydrate. When infused in the striatum, through ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/S0006-8993(96)01319-4
更新日期：1997-02-28 00:00:00
abstract：:Currently there are no uniform standard treatments for newborn suffering from cerebral hypoxia-ischemia (HI) and to find new and effective strategies for treating the HI injury remains a key direction for future research. Present study was designed to demonstrate that optimal dose (1 or 3%) of creatine monohydrate (Cr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.11.017
更新日期：2015-01-21 00:00:00
abstract：:This study used microdialysis to measure changes in extracellular acetylcholine (ACh) content in the nucleus accumbens (NAC) of freely moving rats during acute and chronic morphine treatment, and following naloxone-precipitated withdrawal. Morphine injection (20 mg/kg, i.p.) caused a significant decrease in extracellu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91616-9
更新日期：1991-10-11 00:00:00
abstract：:The present experiments were designed to assess whether brain hypothermia can reduce the behavioral and histopathological deficits associated with global forebrain ischemia. Animals were subjected to 12.5 min of four vessel occlusion (4VO) with moderate hypotension, and brain temperature maintained at either 37 degree...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90945-6
更新日期：1992-05-15 00:00:00
abstract：:During normal aging, men experience a significant decline in testosterone levels and a compensatory elevation in levels of gonadotropin luteinizing hormone (LH). Both low testosterone and elevated LH have been identified as significant risk factors for the development of Alzheimer's disease (AD) in men. It is unclear ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.05.011
更新日期：2012-07-23 00:00:00
abstract：:A large body of evidence indicates that both the altered cytokines that mediate the immune-inflammatory process and abnormal gray matter are associated with schizophrenia. Whether peripheral cytokines are related to cerebral structural abnormality remains unclear. Therefore, we aimed to investigate the association of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146463
更新日期：2019-12-01 00:00:00
abstract：:The spinal nucleus of the bulbocavernosus (SNB) is a sexually dimorphic group of motoneurons in Rexed's Lamina X of the lumbosacral spinal cord of the Mongolian gerbil. The SNB innervates the perineal musculature, the bulbocavernosus (BC), levator ani (LA), and external anal sphincter (EAS). Recent studies demonstrate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02949-9
更新日期：2002-10-25 00:00:00
abstract：:Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02400-8
更新日期：2000-07-07 00:00:00
abstract：:Progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta is the main histopathological characteristic of Parkinson's disease. We studied the electrophysiological characteristics of the spontaneous activity of substantia nigra pars compacta dopaminergic neurons in rats with a partial, unil...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.052
更新日期：2006-04-21 00:00:00
abstract：:In the preceding series of articles, the history of vertebrate motoneuron and motor unit neurobiological studies has been discussed. In this article, we select a few examples of recent advances in neuroscience and discuss their application or potential application to the study of motoneurons and the control of movemen...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2011.06.008
更新日期：2011-08-29 00:00:00
abstract：:Newborn rats were given saline or cholecystokinin8 (CCK8) (5 micrograms/kg, twice daily) i.p. for 3 weeks. On day 21, effects on brain development were assessed. CCK-like immunoreactivity was measured in 7 brain regions; a small (12-18%) but significant decrease in endogenous levels of this peptide was detected in cer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90147-7
更新日期：1987-03-01 00:00:00
abstract：:The effects of bilateral intracranial injections of the D-1 dopamine receptor antagonist SCH 23390 HCl (0, 0.8, 1.6, 3.2, and 6.4 microgram total bilateral dose) administered into the dorsolateral bed nucleus of the stria terminalis (dlBNST) immediately prior to a 3 h intravenous cocaine self-administration session we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01190-6
更新日期：1998-02-16 00:00:00
abstract：:The ability to detect moving objects is crucial for survival and is a basic capability in the animal kingdom. In the optic tectum, a major center of the visual pathway of birds, neurons have been found that seem to be perfectly suited to encode motion. These cells, located in the stratum griseum centrale, receive a di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.022
更新日期：2016-03-15 00:00:00
abstract：:Kindling of the amygdaloid complex in rats results in an enhanced emotionality frequently expressed by an elevated anxiety and defensive attitude toward other animals. Defensive attitude may have important consequences in social context and if tested in a large space it may eventually lead to social withdrawal. To tes...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03162-6
更新日期：2001-12-13 00:00:00
abstract：:Parkinson's disease (PD) is caused by oxidative stress, and erythropoietin (EPO) reduces oxidative stress in the brain. However, EPO cannot be developed as a treatment for PD, because EPO does not cross the blood-brain barrier (BBB). A brain penetrating form of human EPO has been developed wherein EPO is fused to a ch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.061
更新日期：2011-03-25 00:00:00
