Abstract:
:The release of adipokinetic hormones from the neurosecretory cells within the glandular lobe of the corpus cardiacum (CC) of locusts is under the synaptic control of axons within the nervi corporis cardiaca II (NCC II). This synapse has been shown to be aminergic with the transmitter tentatively identified as octopamine. We show here that stimulation of the presynaptic nerves in NCC II produces an increase in adenosine 3',5'-monophosphate (cyclic AMP) in the glandular lobe. Application of octopamine mimics the effect of nerve stimulation. These and other experiments lead us to believe the increase in cyclic AMP is coupled to the process of synaptic transmission, and that the increase occurs within the intrinsic neurosecretory cells of the glandular lobe.
journal_name
Brain Resjournal_title
Brain researchauthors
Orchard I,Loughton BG,Gole JW,Downer RGdoi
10.1016/0006-8993(83)91242-8subject
Has Abstractpub_date
1983-01-03 00:00:00pages
152-5issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(83)91242-8journal_volume
258pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The present study examined whether the inhibition of serotonin transporters (SERT) contributes to cocaine- and other local anesthetics-induced convulsions, and which subtypes of 5-HT receptor are involved in the convulsions. For this purpose, cocaine, meprylcaine and lidocaine, all of which have different effects on S...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.07.049
更新日期:2005-09-28 00:00:00
abstract::(2E)-(5-Hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid (NCS-382) is an antagonist for gamma-hydroxybutyric acid (GHB) at GHB receptor sites. Advantages of using [(3)H]NCS-382 over [(3)H]GHB in radioligand binding studies are that unlike GHB, NCS-382 does not appear to bind to, activate, or i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02865-8
更新日期:2003-07-25 00:00:00
abstract::The number of viable neurones calculated as soon as adult mollusc ganglia tissue was digested and over different periods of cultivation, show that elevated K+ prevents degradation of intercellular contacts, preserves neurones against lysis, prolongs the time course of neurone survival in culture and inhibits neurite f...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90044-0
更新日期:1982-03-18 00:00:00
abstract::By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distributio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90981-z
更新日期:1991-05-03 00:00:00
abstract::The prostacyclin (PGI2) formation in cerebral vessels, as reflected by the difference in concentration of internal carotid arterial and internal jugular venous radioimmunoassayed 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), was determined under normocapnic and hypercapnic conditions in 5 patients with mild cereb...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91272-6
更新日期:1983-01-24 00:00:00
abstract::Neuronal expression of brain-derived neurotrophic factor (BDNF) has been implicated in the mechanism of infarct tolerance (resistance to stroke) (H. Yanamoto et al., Infarct tolerance accompanied enhanced BDNF-like immunoreactivity in neuronal nuclei, submitted to Brain Res.), a process that takes more than 7 days fol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)01966-1
更新日期:2000-03-24 00:00:00
abstract::Methylazoxymethanol acetate (MAM)-induced cortical hypoplasia resulted in a 2-fold increase in the concentration of norepinephrine and its metabolite, 3-methoxyl-4-hydroxyphenylglycol sulfate, and a 26% decrease in the Bmax for the beta-receptor ligand, [3H]dihydroalprenolol (DHA) in the rat cortex. Chronic treatment ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90195-x
更新日期:1982-08-01 00:00:00
abstract::The effects of natural (mechanical and gustatory) stimulation of the nasopharynx or electrical stimulation of the pharyngeal branch of the glossopharyngeal (PH-IXth) nerve on the changes in heart rate (HR) and arterial blood pressure (BP) were investigated in paralyzed and anesthetized rats. Afferent responses in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91614-x
更新日期:1993-08-13 00:00:00
abstract::Central nervous system (CNS) disorders are important targets for gene therapy; however, delivery of therapeutic proteins and/or genes to the brain remains a major challenge due to the difficulty of efficiently delivering viral vectors across the blood-brain barrier (BBB). In the present work, we tested the ability of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.03.014
更新日期:2011-05-10 00:00:00
abstract::These experiments were designed to test the hypothesis that the TxA2 mimetic, U46,619, would stimulate group III and IV afferent nerve endings from the hindlimb of the anesthetized cat. Nerve impulses were recorded from the dorsal rootlets of the L7-S1 segments of the spinal cord, and afferent units identified by meas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01211-5
更新日期:1997-01-02 00:00:00
abstract::Microinjection of a substance P analogue (1 mM; 7 or 10 nl) into laminae I and II of the L7 dorsal horn of decerebrate cats significantly potentiated (P < 0.05) the increase in arterial pressure evoked by microinjection of L-glutamate (109 mM; 7 or 10 nl) into these spinal sites. Microinjection of the substance P anal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00362-4
更新日期:1997-06-06 00:00:00
abstract::Adult human bone marrow stromal cells (hMSCs) grown in suspension culture gave rise to spheres of neural progenitor (NP) cells, capable of expressing both dopaminergic (DA) and GABAergic (GABA) traits. After transplantation into the Parkinsonian rat, human NPs and neurons were present at 2 weeks. Although no DA neuron...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.109
更新日期:2006-08-23 00:00:00
abstract::Following unilateral destruction of the entorhinal cortical region of the adult rat, the denervated granule cells of the dentate gyrus are reinnervated as a result of the proliferation of a pathway from the surviving contralateral entorhinal area. The present study investigates the cells of origin of this lesion-induc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90837-5
更新日期:1978-05-26 00:00:00
abstract::The objective of the study was to investigate creativity in relation to brain function by assessing creative thinking in various neurological populations. Several measures were employed to assess different facets of creative thinking in clinical groups with frontal lobe, basal ganglia or parietal-temporal lesions rela...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.09.007
更新日期:2012-10-30 00:00:00
abstract::Bilateral removal of the cortical visual area in newborn cats produces degeneration of retinal ganglion cells. Measurements of over 4,000 cells and calculation of neuron densities from sample areas of retina in the adult show that the medium sized cell population in peripheral retina is reduced by 68%, whereas the pop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90480-7
更新日期:1981-05-18 00:00:00
abstract::To test the hypothesis that neurons in the hypothalamic paraventricular nucleus (PVN) may be under both direct and indirect regulation by alpha melanocyte-stimulating hormone (alpha-MSH)-synthesizing neurons of the arcuate nucleus, we determined whether the retrogradely transported marker substance, cholera toxin beta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.023
更新日期:2005-12-07 00:00:00
abstract::Horizontal eye movements, elicited by sinusoidal rotation in darkness, were recorded with a magnetic search coil technique in pigmented rats, hemilabyrinthectomised 8-12 weeks before the investigation. Separate gains during rotation towards the lesioned side (LS) and the intact side (IS) were calculated by a computer ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00329-1
更新日期:1998-06-08 00:00:00
abstract::The influence of emotion on cognition plays an important role in people's everyday life as well as in psychiatric and neurological disorders. The present study used fMRI to examine the neural correlates of cognitive-emotional interactions and its inter-individual differences. Twenty-one healthy males performed a 0-bac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.03.048
更新日期:2007-06-04 00:00:00
abstract::Whereas the role of the hippocampus for spatial learning and long-term memory is largely undisputed, there is less evidence for a participation of hippocampal structures in spatial working memory operations. In an fMRI study (functional magnetic resonance imaging), we therefore examined the role of the hippocampus dur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.065
更新日期:2010-10-01 00:00:00
abstract::The non-toxic neuronal binding domain of tetanus toxin (tetanus toxin fragment C, TTC) has been used as a vector to enhance delivery of potentially therapeutic proteins to motor neurons from the periphery following an intramuscular injection. The unique binding and transport properties of this 50-kDa polypeptide sugge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.03.007
更新日期:2004-06-11 00:00:00
abstract::Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03243-2
更新日期:2002-11-08 00:00:00
abstract::Rat hippocampal slices were incubated with [3H]uridine in vitro to analyze the metabolism of nuclear RNA and the RNA precursor fractions. Labeling of total nuclear RNA was linear for 4 h of incubation and proportional to the concentration of labeled uridine in the incubation medium. Addition of 3.5 X 10(-8) M corticos...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90375-5
更新日期:1984-07-23 00:00:00
abstract::The distribution of degeneration in the vestibular nuclei (VN) has been studied in transversely cut sections from 9 cats with stereotaxically performed lesions in the main reticular formation (RF) of the brain stem (Nauta of Fink and Heimer method). No projection was found from the mesencephalic reticular formation (R...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90224-3
更新日期:1975-09-05 00:00:00
abstract::Recent findings have shown that systemic morphine increases extracellular dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), ascorbic acid (AA) and uric acid concentrations in the striatum of freely moving rats. The morphine-induced increase in DA oxidative metabolism is highly correlated with...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00371-0
更新日期:1998-06-22 00:00:00
abstract::The pedunculopontine nucleus (PPN) located in the mesopontine tegmentum is innervated by descending projections from nuclei in the basal ganglia. The present study was performed to determine whether nigrostriatal dopaminergic neuron degeneration is associated with changes in PPN metabolic activity. Unilateral nigrostr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01268-8
更新日期:1999-05-15 00:00:00
abstract::Plasma concentrations of beta-endorphin were measured by radioimmunoassay in cats prepared chronically for sleep-waking polygraphic recordings and blood collection. beta-Endorphin (beta-END) levels were found to be stable in baseline conditions and were used as an index of stress. After habituation of each cat to expe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91207-6
更新日期:1983-03-14 00:00:00
abstract::The effects of 3 different non-noxious stressors on body temperature (Tb) were investigated in the rat: (1) loose restraint in cylinders, (2) removal of the rats from cylinders, exposure to a novel environment and replacement in cylinders, a stressor called here 'novelty', and (3) gentle holding of the rats by the nap...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90537-7
更新日期:1984-04-09 00:00:00
abstract::The mouse auditory neurons, hair cells and their supporting cells in the cochlea are considered to be generated mainly in the embryonic days and to be sustained throughout the whole life. In the present study, however, we observed that auditory ganglion cells in the spiral ganglia undergo apoptosis and mitosis in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02300-9
更新日期:2001-05-18 00:00:00
abstract::Transient ischemic attack (TIA) has received only little attention in the experimental research field. Recently, we introduced a TIA model for mice, and here we set similar principles for simulating this human condition in Wistar rats. In the model: 1) transient nature of the event is ensured, and 2) 24h after the eve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.03.010
更新日期:2017-05-15 00:00:00
abstract::Previous studies have shown that preganglionic nerve stimulation in vitro increases acutely the activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, in sympathetic neuronal cell bodies in the rat superior cervical ganglion (SCG). In the present study, we have examined whether ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90506-7
更新日期:1990-07-30 00:00:00