Abstract：
:This study is focused to learn about the cellular localization of transcription factors binding to the cAMP response element-CREBs-in the brain of normal rats and in animals subjected to excitotoxic cell damage. For this purpose, CREB-1 and CREB-2 immunoreactivity is examined in the developing and adult rat brain under physiological conditions, and following systemic kainic acid (KA) injection at convulsant doses in the adult, as a validated experimental model of excitotoxic injury. CREB-1 immunoreactivity is constitutively expressed in periventricular glia and Bergmann glia, and appears in reactive astrocytes following KA-induced excitotoxic cell damage. In contrast, CREB-2 is constitutively expressed in all neurons of the cerebrum, cerebellum and brain stem in the developing and adult brain. CREB-2 immunoreactivity is not increased following KA excitotoxic cell damage. These results demonstrate that CREB-1 and CREB-2 in the brain of the rat are localized in separate cellular compartments and that their expression is differentially regulated in pathologic states.
journal_name
Brain Resjournal_title
Brain researchauthors
Ferrer I,Blanco R,Rivera R,Carmona M,Ballabriga J,Olivé M,Planas AMdoi
10.1016/0006-8993(95)01527-2subject
Has Abstractpub_date
1996-03-11 00:00:00pages
159-64issue
1eissn
0006-8993issn
1872-6240pii
0006899395015272journal_volume
712pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Cocaine increases dopamine concentration in the nucleus accumbens through competitive binding to the dopamine transporter (DAT). However, it also increases the frequency of dopamine release events, a finding that cannot be explained by action at the DAT alone. Rather, this effect may be mediated by cocaine-induced mod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.10.022
更新日期：2017-01-15 00:00:00
abstract：:The time courses for development of neuronal and behavioral tolerance to diazepam (DZ) were estimated in rats continuously exposed to low levels of DZ for 3, 7, 14 or 21 days. Microiontophoretic sensitivity of dorsal raphe neurons to gamma-aminobutyric acid (GABA) was initially facilitated after short-term exposure to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90993-0
更新日期：1987-03-03 00:00:00
abstract：:(1) The possibility that water intake elicited by the administration of angiotensin-II to the preoptic region (POA), subfornical organ and anterior third ventricle is mediated by separate neural systems was investigated in 58 male Wistar rats using electrolytic lesion techniques. (2) Lesions of the midlateral hypothal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90189-x
更新日期：1976-05-28 00:00:00
abstract：:Pretreatment with scopolamine, 3 mg/kg, prevented the acquisition of a passive avoidance task in rats. These amnesic effects of scopolamine could largely be overcome by treatment with 100 mg/kg of the nootropic drug piracetam. In order to identify the brain structures involved, the effects of these drugs on regional e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91186-3
更新日期：1987-10-20 00:00:00
abstract：:To test the hypothesis that functional metabolic deficits observed following surgical brain injury are associated with changes in cognitive performance in rodents, we performed serial imaging studies in parallel with behavioral measures in control animals and in animals with surgical implants. Memory function was asse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.134
更新日期：2007-05-04 00:00:00
abstract：:This study examines directly the effects on serotonin release of varying brain tryptophan levels within the physiologic range. It also addresses possible interactions between tryptophan availability and frequency of membrane depolarization in controlling serotonin release. We demonstrate that reducing tryptophan level...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91761-5
更新日期：1990-11-05 00:00:00
abstract：:Several lines of evidence indicate that psychostimulant withdrawal can induce negative emotional symptoms, such as anhedonia and dysphoria, which may be due in part, to dysfunction of the serotonin (5-HT) system, including alterations in 5-HT receptors. For example, changes in 5-HT(2A) receptor function in prefrontal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.033
更新日期：2011-05-16 00:00:00
abstract：:We used double staining immunocytochemical techniques to determine whether nitric oxide (NO) and Fos immunoreactivity induced by noxious visceral stimulation were colocalized in the neurons of the supraspinal areas. We observed a considerable increase in Fos-positive neurons in many brain areas after noxious stimulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01434-1
更新日期：1999-07-10 00:00:00
abstract：:Fluorescence resonance energy transfer (FRET) is a widely utilized optical technique for measuring small distances of 1-10 nm in live cells. In recent years, its application has been greatly popularized by the discovery of green fluorescent protein (GFP) and many improved variants which make good donor-acceptor fluoro...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2006.01.119
更新日期：2006-05-26 00:00:00
abstract：:The main goal of the present study was to analyse the effects of (+/-)-huprine X ((+/-)-HX) and galantamine (GAL), with potentiating action on nicotinic receptors, and huperzine A (HPA), devoid of nicotinic activity, on [3H]-acetylcholine ([3H]-ACh) release in striatal slices of rat brain. All compounds are non-covale...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.042
更新日期：2005-11-09 00:00:00
abstract：:Approximately 40-60% of BXSB mice have ectopic cell clusters in layer 1 of neocortex. Prior studies have shown distinct behavioral differences between those with ectopias and their non-ectopic littermates. In this study, female BXSB mice were reared after weaning in either enriched environments or standard cages. Foll...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-07-08 00:00:00
abstract：:The transcription factor Phox2b is necessary for the development of the nucleus of the solitary tract (NTS). In this brainstem nucleus, Phox2b is expressed exclusively within a subpopulation of glutamatergic neurons. The present experiments in the adult rat were designed to test whether this subpopulation includes the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.072
更新日期：2008-08-21 00:00:00
abstract：:Spreading depression (SD) is a wave of cellular depolarization which contributes to neuronal damage in experimental focal ischaemia, and may also underlie the migraine aura. The purpose of this study was to examine the effects of probenecid, an inhibitor of organic anion transport, on K+-evoked SD in vivo. Microdialys...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00434-4
更新日期：1997-08-01 00:00:00
abstract：:The effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain edema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain. Brain edema was assessed by measurement of water and electrolyte contents of the brain. The results showed that pretreatme...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90439-3
更新日期：1989-06-19 00:00:00
abstract：:The associative learning functions of the central nervous system of Limax maximus have been established with behavioral experiments on intact animals (Sahley et al., J. comp. Physiol., 144 (1981) 1) and physiological experiments on the isolated CNS (Culligan and Gelperin, Brain Research, 266 (1983) 319). We now report...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90323-8
更新日期：1984-06-25 00:00:00
abstract：:The compound m-chlorophenylpiperazine (m-CPP) is used clinically to manipulate serotonergic function, though its precise mechanisms of actions are not well understood. m-CPP alters synaptic transmission and neuronal function in vertebrates by non-selective agonistic actions on 5-HT(1) and 5-HT(2) receptors. In this st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02271-6
更新日期：2003-04-18 00:00:00
abstract：:In spite of the numerous reports on the optic fiber distribution in the optic nerve and tract of vertebrates, there have been few studies of the visual pathway in reptiles. The arrangement of fibers in the optic nerve and tract of the turtle Mauremys leprosa was studied by placing a small granule of carbocyanine dye (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.10.016
更新日期：2007-12-01 00:00:00
abstract：:We examined the contribution of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxalole-4-propionic acid (AMPA)/kainate (KA) receptors to the light-responses of rabbit retinal neurons. In the outer retina, bath application of the AMPA/KA receptor antagonists 6,7-dinitro-quinoxaline-2,3-dione (DNQX) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01448-1
更新日期：1999-06-12 00:00:00
abstract：:While exercise is commonly recommended for PD patients to improve motor function, little is known about the disease-altering potential of exercise. Although others have demonstrated neuroprotective or neurorestorative effects of exercise in animal models of PD, the majority of these studies utilize young animals. In o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.06.032
更新日期：2016-09-01 00:00:00
abstract：:The success of neuromodulation therapies, particularly in the brain, spinal cord, and peripheral nerves, has been greatly aided by computational, biophysical models. However, treating gastrointestinal disorders with electrical stimulation has been much less explored, partly because the mode of action of such treatment...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.02.038
更新日期：2018-08-15 00:00:00
abstract：:The Reelin signaling pathway controls radial neuronal migration and maturation in the developing brain. The platelet activating factor (PAF) acetyl hydrolase 1b (Pafah1b) complex is also involved in multiple aspects of brain development. We previously showed that the Reelin pathway and the Pafah1b complex interact gen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.059
更新日期：2009-04-24 00:00:00
abstract：:Non-peptide receptor ligands with differential affinity for the angiotensin II-1 (AII-1) receptor (EXP3312, EXP3880) or the AII-2 receptor (PD123177) and an angiotensin converting enzyme (ACE) inhibitor captopril were evaluated for the ability to protect against a renin-induced performance deficit in a passive avoidan...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91599-v
更新日期：1991-10-11 00:00:00
abstract：:Rarely do we encounter a single odorant in our environment. Perception of odours, therefore, usually depends on the reception and neural processing of many components. However, little is known about how and where odour mixtures are processed. Evidence is presented here that suppression of one odour by another, a commo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90419-7
更新日期：1987-11-17 00:00:00
abstract：:Retrograde transport of horseradish peroxidase (HRP) was used to identify supraependymal neurons projecting to the pituitary gland in the hamster. Supraependymal neurons overlying the median eminence were labeled by HRP injections into the neural and intermediate lobes of the pituitary gland; no neurons were labeled f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91502-3
更新日期：1989-01-30 00:00:00
abstract：:Stress stimulates the adrenal medulla to rapidly secrete catecholamines (CAs), and the adrenal cortex to release progesterone (PROG), which may locally regulate stress-induced CA release. We used bovine chromaffin cells to investigate the effects of PROG on CA secretion. PROG dose-dependently inhibited CA secretion in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.040
更新日期：2005-05-10 00:00:00
abstract：:Past studies in the rat and Syrian hamster show that metabolic and electrical activity of the suprachiasmatic nuclei (SCN) is inhibited by melatonin (MEL) at about circadian time (ct) 8-11 h. The present experiment examined the effect of MEL on the firing frequency of SCN cells in brain slices prepared from long day (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90853-f
更新日期：1993-04-23 00:00:00
abstract：:In a previous study we reported significant elevations of TRH in neocortex, hippocampus and combined amygdala/pyriform cortex in rats 48 h after the last of a series of stage 5 kindled seizures. In the present study, to determine whether the increases in TRH were proportional to the intensity of the convulsions, and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91330-j
更新日期：1990-08-13 00:00:00
abstract：:Patterns of proliferation and changes in non-neuronal cell number in the visual system of the goldfish have been quantitatively examined during optic axon regeneration after an optic nerve crush (ONC). In addition, in order to examine the effect of the regenerating axons on cellular responses in the visual pathways, w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02339-2
更新日期：2000-01-31 00:00:00
abstract：:Dopaminergic and glutamatergic afferents simultaneously innervate median spiny neurons (MSNs) and interact to mediate basal ganglia functions. However, the association between dopaminergic and glutamatergic axons is not clear. In the present study, nigrostriatal, corticostriatal, and thalamostriatal axons were anterog...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.09.032
更新日期：2012-11-27 00:00:00
abstract：:A cyto- and myeloarchitectonic parcellation of the superior temporal sulcus and surrounding cortex in the rhesus monkey has been correlated with the pattern of afferent cortical connections from ipsilateral temporal, parietal and occipital lobes, studied by both silver impregnation and autoradiographic techniques. The...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90584-x
更新日期：1978-06-23 00:00:00
