Time course for development of anticonvulsant tolerance and GABAergic subsensitivity after chronic diazepam.

abstract：:The immunohistochemical localization of an endogenous lectin R1 isolated from the rat cerebellum was studied during its postnatal development. The lectin is present in the cerebellum from birth to adulthood, essentially in lysosomes, multivesicular bodies, and parts of the endoplasmic reticulum, principally of large a...

journal_title：Brain research

authors： Dontenwill M,Roussel G,Zanetta JP

更新日期：1985-01-01 00:00:00

abstract：:Circadian and neural mechanisms important for the organization of reproductive behavior in the male golden hamster were examined. The sexual behavior of male hamsters exhibits diel variations; males are quicker to initiate copulation and to ejaculate in the dark phase than in the light phase of a daily light-dark cycl...

journal_title：Brain research

authors： Eskes GA

更新日期：1984-02-13 00:00:00

abstract：:Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no signif...

journal_title：Brain research

authors： Mashal RD,Owen F,Deakin JF,Poulter M

更新日期：1983-10-31 00:00:00

abstract：:The reactivity of dopaminergic (DA) terminals in the nucleus accumbens was investigated in male rats submitted to tail-pinch or various social interactions. The DA activity was assessed by measurement of the presynaptic metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) by using differential pulse voltammetry in free m...

journal_title：Brain research

authors： Louilot A,Le Moal M,Simon H

更新日期：1986-11-12 00:00:00

abstract：:The goal of the present study was to identify the projection from the subdivisions of the amygdaloid nuclear complex to specified subregions of the dorsal raphe (DR) nucleus and to attempt to compare the density of amygdaloid input to the DR with that of inputs from other limbic structures. Use of a retrograde tracer,...

journal_title：Brain research

authors： Lee HS,Eum YJ,Jo SM,Waterhouse BD

更新日期：2007-04-27 00:00:00

abstract：:Neurological problems can develop when blood glucose levels rapidly rise or fall yet there has been little experimentation at a cellular level to assess how neurophysiological change may be induced. Using intracellular recording in the rat neocortical slice preparation, we examined pyramidal neurons of layers II-III a...

journal_title：Brain research

authors： Rosen AS,Andrew RD

更新日期：1991-07-26 00:00:00

abstract：:Different groups of rats received three injections of either D-amphetamine (2.5 micrograms/0.5 microliters/side) or saline into the ventral tegmental area (VTA), one injection every third day. Two weeks following the last injection, dopamine (DA) neurotransmission in the nucleus accumbens (N. Acc.) was assessed with i...

journal_title：Brain research

authors： Vezina P

更新日期：1993-03-12 00:00:00

abstract：:It is well established that extracellular choline is transported into central cholinergic nerve terminals by 'high' and 'low' affinity processes to form the neurotransmitter acetylcholine (ACh). The intent of the present investigation was to ascertain whether extracellular acetate might also be transported into centra...

journal_title：Brain research

authors： Carroll PT

更新日期：1997-04-04 00:00:00

abstract：:The time course of the variations in tyrosine hydroxylase (TH) activity was measured in the rat locus coeruleus (LC) after lesions of the nucleus raphe dorsalis (NRD), nucleus raphe centralis superior (NRCS) and nucleus raphe pontis (NRP). A certain number of lesions were performed in the raphe magnus (RM), the caudal...

journal_title：Brain research

authors： McRae-Degueurce A,Berod A,Mermet A,Keller A,Chouvet G,Joh TH,Pujol JF

更新日期：1982-03-11 00:00:00

abstract：:The neurosteroid allopregnanolone is a potent and efficacious modulator of gamma-aminobutyric acid (GABA) type A receptors. The effects of intracerebroventricular injection of allopregnanolone (5 to 15 micrograms/5 microliters) on basal and stress-induced release of acetylcholine were investigated in various regions o...

journal_title：Brain research

authors： Dazzi L,Sanna A,Cagetti E,Concas A,Biggio G

更新日期：1996-02-26 00:00:00

abstract：:Growth cones integrate a remarkably complex concert of chemical cues to guide axons to their appropriate destinations. Recent work suggests that integrins contribute to axon guidance by interacting with a wide range of extracellular molecules including axon guidance molecules, by mechanisms that are not fully understo...

journal_title：Brain research

authors： Lemons ML,Abanto ML,Dambrouskas N,Clements CC,Deloughery Z,Garozzo J,Condic ML

更新日期：2013-11-06 00:00:00

abstract：:Neuronal transmission through hippocampal subfields exhibits a high degree of modulation and appears dependent on the behavioral state and hippocampal EEG. Sensory inputs, which profoundly modify the hippocampal EEG, may be involved in modulating hippocampal excitability. Field responses of the CA1 region, evoked by i...

journal_title：Brain research

authors： Herreras O,Solís JM,Muñoz MD,Martín del Río R,Lerma J

更新日期：1988-10-04 00:00:00

abstract：:We have previously demonstrated that Fos immunoreactivity can be stimulated by KCl, forskolin or glutamate in cultured tyrosine hydroxylase-immunoreactive (TH-ir) hypothalamic neurons. The present study was performed to determine whether agents that regulate dopaminergic activity, particularly D1 and D2 receptor agoni...

journal_title：Brain research

authors： Sim LJ,Selley DE,Tsai KP,Morris M

更新日期：1994-07-18 00:00:00

abstract：:parkin is the most frequent causative gene among familial Parkinson's disease (PD). Although parkin deficiency induces autosomal recessive juvenile parkinsonism (AR-JP, PARK2) in humans, parkin knockout (PKO) mice consistently show few signs of dopaminergic degeneration. We aimed to directly measure evoked extracellul...

journal_title：Brain research

authors： Oyama G,Yoshimi K,Natori S,Chikaoka Y,Ren YR,Funayama M,Shimo Y,Takahashi R,Nakazato T,Kitazawa S,Hattori N

更新日期：2010-09-17 00:00:00

abstract：:In the developing vertebrate retina, precise coordination of retinal progenitor cell proliferation and cell-cycle exit is essential for the formation of a functionally mature retina. Unregulated or disrupted cell proliferation may lead to dysplasia, retinal degeneration or retinoblastoma. Both cell-intrinsic and -extr...

journal_title：Brain research

authors： Martins RA,Pearson RA

更新日期：2008-02-04 00:00:00

abstract：:In decerebrate rats, the responses of tilt-sensitive neurons in the lateral and descending vestibular nuclei were studied during constant velocity 10 degrees off-vertical axis rotations (OVAR) in the clockwise (VW) and counterclockwise (CCW) directions. Seventy three otolith-related units showed a sinusoidal position-...

journal_title：Brain research

authors： Lai CH,Chan YS

更新日期：1995-09-25 00:00:00

abstract：:Axonal flow of motoneurons was blocked in the sciatic nerve by the application of vinblastine at a low concentration (100 microM) not considered likely to cause axonal degeneration. The number of motoneurons expressing alpha-calcitonin gene-related peptide (CGRP) mRNA was significantly increased by vinblastine applica...

journal_title：Brain research

authors： Katoh K,Tohyama M,Noguchi K,Senba E

更新日期：1992-12-18 00:00:00

abstract：:Astrogliogenesis in the human fetal cerebellum was examined in 46 cerebella obtained from hysterotomy specimens ranging between 9 and 20 weeks of ovulation age. By correlating the results obtained by rapid Golgi and Golgi-Cox methods, the indirect immunofluorescence technique for glial fibrillary acidic protein, and e...

journal_title：Brain research

authors： Choi BH,Lapham LW

更新日期：1980-05-26 00:00:00

abstract：:Nerve injury was produced by application of dry ice to the common peroneal nerve. After 20 weeks, muscle-spindle primary endings responded normally to stretch and the spindles were found to have a fully functional fusimotor innervation. ...

journal_title：Brain research

authors： Scott JJ

更新日期：1985-11-25 00:00:00

abstract：:Visual spatial orienting of attention towards exogenous cues has been one of the attentional functions considered to be spared in ADHD. Here we present a design in which 60 (30 ADHD) children, age: 10.9±1.4, were asked to covertly orient their attention to one or two (out of four) cued locations, and search for a targ...

journal_title：Brain research

authors： Ortega R,López V,Carrasco X,Anllo-Vento L,Aboitiz F

更新日期：2013-02-01 00:00:00

abstract：:Defined concentrations of quinolinate (QUIN) were administered to murine cortical neurons in culture impaled for intracellular recording. In physiological recording medium containing 1 mM Mg, concentrations of QUIN up to 2 mM had minimal effect on membrane potential and input resistance; only at higher concentrations ...

journal_title：Brain research

authors： Peters S,Choi DW

更新日期：1987-09-08 00:00:00

abstract：:Triiodothyronine (T3) plays an important role during development of the central nervous system. T3 effects on gene expression are determined in part by the type of thyroid hormone receptors (TRs) expressed in a given cell type. Previous studies have demonstrated that thyrotropin releasing hormone (TRH) transcription i...

journal_title：Brain research

authors： Carreón-Rodríguez A,Charli JL,Pérez-Martínez L

更新日期：2009-12-11 00:00:00

abstract：:Picrotoxin-induced epileptiform activity was examined in neocortical slices prepared from 8- to 15-day-old rats. This activity consisted of spontaneous bursts of 3-5 discharges that resembled interictal spikes and were interspersed with ictal-like paroxysms lasting 10-30 s. Measurements of extracellular potassium ([K+...

journal_title：Brain research

authors： Hablitz JJ,Heinemann U

更新日期：1987-12-01 00:00:00

abstract：:The aim of this study was to identify the medullary vagal nuclei involved in the different phases of swallowing activated physiologically in a species with an esophagus similar to human. In decerebrate cats, the pharyngeal (0.5-1.0 ml water in pharynx (N=6)) or esophageal (1-3 ml air in esophagus (N=5)) phases of swal...

journal_title：Brain research

authors： Lang IM,Dean C,Medda BK,Aslam M,Shaker R

更新日期：2004-07-16 00:00:00

abstract：:Maternal care is crucial for offspring development and licking/grooming patterns can be induced by sensorial, neuroendocrine, and metabolic variations in the CNS. Important brain functions, such as learning and memory, can be influenced by oxidative stress, which can also modulate pathophysiological processes (e.g., d...

journal_title：Brain research

authors： De Moura AC,Brito VB,Porawski M,Saffi J,Giovenardi M

更新日期：2017-01-15 00:00:00

abstract：:The alpha-2 adrenergic agonist dexmedetomidine (Dex), 3-300 microg/kg, i.p., decreased cerebellar cGMP in a dose-dependent manner. Fentanyl (F), an opioid agonist, increased cerebellar cGMP at 0.3 mg/kg, s.c., and decreased it at doses >/=1 mg/kg. The inhibitory effect was receptor specific, that of Dex being blocked ...

journal_title：Brain research

authors： Vulliemoz Y,Virag L,Whittington RA

更新日期：1998-11-30 00:00:00

abstract：:The role of polyamines in the regulation of free intrasynaptosomal Ca2+, [Ca2+]i was studied. After preincubation of rat brain synaptosomes with 5 mM difluormethylornithine (DFMO), an irreversible inhibitor of ornithine decarboxylase, the K+-induced increase of [Ca2+]i was 33% less than that in non-treated synaptosome...

journal_title：Brain research

authors： Komulainen H,Bondy SC

更新日期：1987-01-13 00:00:00

abstract：:Glucocorticoids exacerbate aging-induced cell death, but relatively little is known about other CNS effects in senescence. We examined noradrenergic/adenylyl cyclase signaling in the cerebellum, which is a brain region that is susceptible to deterioration of synaptic function in aging. Aged control rats had increased ...

journal_title：Brain research

authors： Slotkin TA,Zhang J,McCook EC,Seidler FJ

更新日期：1998-08-03 00:00:00

abstract：:Ventilated, chloralose anesthetized cats were subjected to 3.2 atmosphere fluid percussion injury and compared with sham operated controls. In both groups, global cerebral blood flow (CBF), cerebral metabolic rate of oxygen utilization (CMRO2), cerebral metabolic rate of glucose utilization (CMRG1), and 31P magnetic r...

journal_title：Brain research

authors： Andersen BJ,Marmarou A

更新日期：1992-07-10 00:00:00

abstract：:Febrile seizure (FS) remains the most common childhood neurological emergency. Although many studies have been done, controversy exists as to whether these seizures are associated with a significant risk for cognitive impairment. The aim of our study is to check whether there is a spatial learning and memory deficit i...

journal_title：Brain research

authors： Xiong Y,Zhou H,Zhang L

更新日期：2014-04-04 00:00:00