Inhibition by the neurosteroid allopregnanolone of basal and stress-induced acetylcholine release in the brain of freely moving rats.

abstract：:Excitatory amino acids (EAAs) are likely to play a key role in sensory transmission in the spinal cord. In the present study, the microiontophoresis technique was used to investigate the effects of L-glutamate (GLUT), N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor antagonist, AP-7, on...

journal_title：Brain research

authors： Dougherty PM,Willis WD

更新日期：1991-02-22 00:00:00

abstract：:Stimulation of cardiac sympathetic afferents evokes excitatory cardiovascular reflexes. However, the exact regions in the brain that integrate these reflexes have not been identified. Expression of c-Fos in the neurons provides a useful marker of the activated neurons. In the present study, we examined the response of...

journal_title：Brain research

authors： Guo ZL,Lai HC,Longhurst JC

更新日期：2002-01-18 00:00:00

abstract：:Multiple retrograde fluorescent tracing was employed to investigate the organization of the rat entopeduncular nucleus projections to the lateral habenula, ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The results indicate that neur...

journal_title：Brain research

authors： van der Kooy D,Carter DA

更新日期：1981-04-27 00:00:00

abstract：:We studied the effects of nitric oxide (NO) and the NO-releasing agents sodium nitroprusside (SNP), S-nitroso-N-acetylpenicillamine (SNAP) and isosorbide dinitrate (ISDN) on N-methyl-D-aspartate (NMDA)-induced increases in intracellular Ca2+ ([Ca2+]i), whole-cell patch-clamp currents and on glutamate-stimulated [3H]di...

journal_title：Brain research

authors： Hoyt KR,Tang LH,Aizenman E,Reynolds IJ

更新日期：1992-10-02 00:00:00

abstract：:Phonological working memory (PWM) tasks consist of a sequence of stimulus-encoding, maintenance and response. Few previous functional magnetic resonance imaging (fMRI) studies of PWM have employed event-related designs that make it possible to analyze the activations associated with each phase of such a task. The expl...

journal_title：Brain research

authors： Strand F,Forssberg H,Klingberg T,Norrelgen F

更新日期：2008-05-30 00:00:00

abstract：:A method for selectively labeling the CNS neurons that give rise to zinc-containing axonal boutons is described. Focal intracerebral infusions of selenium anions are used to produce a precipitate (presumably ZnSe) in zinc-containing axonal boutons at the injection site, and within 24-48 h, the precipitate is transport...

journal_title：Brain research

authors： Howell GA,Frederickson CJ

更新日期：1990-05-07 00:00:00

abstract：:The effect of five daily intraperitoneal (i.p.) injections of NT69L on in vitro dopamine release, uptake, and [(3)H]NT binding in rat striatal tissue was investigated. NT69L perfusion increased K(+)-evoked and electrically evoked [(3)H]DA release. NT receptor-1 antagonist SR48692 inhibited the stimulatory effect of NT...

journal_title：Brain research

authors： Wang R,Boules M,Tiner W,Richelson E

更新日期：2004-10-29 00:00:00

abstract：:When rat striatal membranes, photolabeled with [3H]dopamine under assay conditions similar to those used for dopamine-sensitive adenylate cyclase, were subjected to sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis, several radioactively labeled bands appeared. Labeling of these bands was reduced in the ...

journal_title：Brain research

authors： Kuno T,Tanaka C

更新日期：1981-12-28 00:00:00

abstract：:We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-d-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of brain-derived neuro...

journal_title：Brain research

authors： Neal AP,Stansfield KH,Guilarte TR

更新日期：2012-02-23 00:00:00

abstract：:The effect of 4-aminopyridine (4-AP) on the release of labeled transmitters in mouse brain synaptosomes was studied in a superfusion system. 4-AP at microM concentrations notably stimulated the spontaneous release of labeled GABA and glutamate, and of acetylcholine (ACh) derived from tritiated choline. No effects on t...

journal_title：Brain research

authors： Tapia R,Sitges M

更新日期：1982-11-04 00:00:00

abstract：:Due to the structural similarity to N-methyl-4-phenyl pyridinium (MPP(+)), paraquat might induce dopaminergic toxicity in the brain. However, its blood--brain barrier (BBB) penetration has not been well documented. We studied the manner of BBB penetration and neural cell uptake of paraquat using a brain microdialysis ...

journal_title：Brain research

authors： Shimizu K,Ohtaki K,Matsubara K,Aoyama K,Uezono T,Saito O,Suno M,Ogawa K,Hayase N,Kimura K,Shiono H

更新日期：2001-07-06 00:00:00

abstract：:A major function of the dopamine in the striatum is to control the activity of its efferent systems which contain primarily GABAergic neurons. Direct intracerebral injections of haloperidol into the corpus striatum impaired the performance of rats trained to depress a lever in a sensitive reaction time task. Rats were...

journal_title：Brain research

authors： Amalric M,Koob GF

更新日期：1989-04-03 00:00:00

abstract：:Rat cerebral cortex slices were incubated in small volumes of medium in order to study the bidirectional movements of gamma-aminobutyric acid (GABA) between tissue and medium, and to measure the extent of release of endogenous amino acids of interest as potential neurotransmitters. The apparent uptake, real uptake, an...

journal_title：Brain research

authors： Cutler RW,Young J

更新日期：1979-04-13 00:00:00

abstract：:Transgenic mice expressing human APPswe and PS1-A264E mutations mimic certain neuropathological features of Alzheimer's disease (AD). These mice have elevated levels of the highly fibrillogenic amyloid beta1-42 peptide (Abeta42) and develop amyloid plaques around the age of 9 months. Our aim was to find whether these ...

journal_title：Brain research

authors： Wang J,Ikonen S,Gurevicius K,van Groen T,Tanila H

更新日期：2002-07-12 00:00:00

abstract：:Deposition of beta-amyloid (A beta) is a characteristic feature of the pathology of Alzheimer's disease (AD). Since glucose metabolism and the consequential ATP production are depressed in the temporal and parietal regions of the cortex in patients with AD, we designed the present study to investigate the possible rol...

journal_title：Brain research

authors： Shi J,Xiang Y,Simpkins JW

更新日期：1997-10-24 00:00:00

abstract：:There is a sizeable literature concerning basal ganglia (BG) functioning that is based on data from experiments employing a method of analysis that is traditionally used with other motor areas. A brief review of this literature is presented and the following conclusion is reached: as compared to the success of traditi...

journal_title：Brain research

authors： Lidsky TI,Manetto C,Schneider JS

更新日期：1985-06-01 00:00:00

abstract：:In the present study, we used an innovative music-rest interleaved fMRI paradigm to investigate the neural correlates of tinnitus distress. Tinnitus is a poorly-understood hearing disorder where individuals perceive sounds, in the absence of an external source. Although the great majority of individuals habituate to c...

journal_title：Brain research

authors： Shahsavarani S,Schmidt SA,Khan RA,Tai Y,Husain FT

更新日期：2021-01-07 00:00:00

abstract：:The effects of recombinant mouse stem cell factor (rmSCF) on paired-pulse facilitation (PPF) and long-term potentiation (LTP) in the mossy fiber (MF)-CA3 pathway were examined in mouse hippocampal slices by recording field EPSPs. When PPF was measured before and 30 min after tetanic stimulation, the initial PPF positi...

journal_title：Brain research

authors： Kondo T,Katafuchi T,Hori T

更新日期：2002-08-16 00:00:00

abstract：:This work examines the age-related changes of the NO pathway in the central nervous system (CNS), analyzing nitric oxide synthase (NOS) isoform expression, the level of nitrotyrosine-modified proteins, and the NOS activity in the cerebral cortex, decorticated brain (basal ganglia, thalamus, hypothalamus, tegtum and te...

journal_title：Brain research

authors： Siles E,Martínez-Lara E,Cañuelo A,Sánchez M,Hernández R,López-Ramos JC,Del Moral ML,Esteban FJ,Blanco S,Pedrosa JA,Rodrigo J,Peinado MA

更新日期：2002-11-29 00:00:00

abstract：:Serum-free aggregating cell cultures of fetal rat telencephalon grown in the presence of 3 ng/ml (5 X 10(-10) M) epidermal growth factor (EGF) until day 12 showed 2- to 3-fold increased activities in the two glial enzymes, glutamine synthetase (GLU-S) and 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase). This effe...

journal_title：Brain research

authors： Honegger P,Guentert-Lauber B

更新日期：1983-12-01 00:00:00

abstract：:Children with Asperger's Disorder or High Functioning Autism are included in regular education classes but find themselves excluded from the social lives of their classmates. This paper briefly reviews studies which attempt to provide them with training to overcome their social difficulties. These interventions have h...

journal_title：Brain research

authors： Frankel F,Whitham C

更新日期：2011-03-22 00:00:00

abstract：BACKGROUND INFORMATION:We recently proposed novel neurobiological ideas for discussion regarding the common nature (malfunction of a physicochemical phenomenon genetically programmed for the morphological execution of ontogenetic apoptosis), mechanism of formation (phase transition in an intraneuronal gel structure) an...

journal_title：Brain research

authors： Kövesdi E,Pál J,Gallyas F

更新日期：2007-05-25 00:00:00

abstract：:Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in ...

journal_title：Brain research

authors： Aghajanian GK,Kogan JH,Moghaddam B

更新日期：1994-02-04 00:00:00

abstract：:In anaesthetized cats, effects of iontophoretic application of angiotensin II were studied in the nuclei of the tractus solitarius. Specifically, its effects were tested on single respiratory neurones, having rhythmic activity related temporally with the phrenic nerve discharge, and on presumed reflex interneurones, w...

journal_title：Brain research

authors： Sessle BJ,Henry JL

更新日期：1987-03-24 00:00:00

abstract：:Studies related to brain oscillations pervade the neuroscience literature. Functional correlates of oscillations in the delta, theta, alpha, beta and gamma frequency windows are interpreted in several ways. However, only a small number of reports indicate the need for overall interpretations by integrating all type of...

journal_title：Brain research

authors： Başar E

更新日期：2008-10-15 00:00:00

abstract：:The specific binding of [3H]neurotensin binding to the rat striatum was characterized and its localization investigated by using frontal cortex ablations and the neurotoxins kainic acid and 6-hydroxydopamine. Scatchard analysis indicated the existence of a single population of binding sites and the potencies of variou...

journal_title：Brain research

authors： Goedert M,Pittaway K,Emson PC

更新日期：1984-05-07 00:00:00

abstract：:Rapid eye movement (REM) sleep is hypothesized to result from the activity of REM sleep-generating and REM sleep-inhibiting neurons. The serotoninergic (5-HT) neurons of the dorsal raphe nucleus (DRN) represents one such population of REM-sleep inhibiting neurons since they are silent during REM sleep. Consistent with...

journal_title：Brain research

authors： Blanco-Centurion CA,Salin-Pascual RJ

更新日期：2001-12-27 00:00:00

abstract：:An interesting feature of the kindling phenomenon relates to the finding that kindling established in one region of the brain may reduce the number of stimulations required to establish the phenomenon in a second region. It has been proposed that this 'transfer' phenomenon reflects the extent to which seizures arising...

journal_title：Brain research

authors： Buchanan JA,Bilkey DK

更新日期：1997-10-10 00:00:00

abstract：:Proliferative response of astrocytes to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats using a combination of [3H]thymidine autoradiography and immunocytochemical staining for glial fibrillary acidic protein. At different intervals following injury the animals were injected with [3H]t...

journal_title：Brain research

authors： Janeczko K

更新日期：1989-04-24 00:00:00

abstract：:In the dorsal lateral geniculate nucleus (LGN) of the adult cat there is no evidence for translaminar sprouting of retinal axons to fill sites freed of retinal endings from the other eye. We tested the possibility that retinal axons will sprout to fill denervated retinal sites within laminae of the monkey LGN. In 4 mo...

journal_title：Brain research

authors： Stelzner DJ,Keating EG

更新日期：1977-05-06 00:00:00