Lack of intralaminar sprouting of retinal axons in monkey LGN.

Abstract:

:In the dorsal lateral geniculate nucleus (LGN) of the adult cat there is no evidence for translaminar sprouting of retinal axons to fill sites freed of retinal endings from the other eye. We tested the possibility that retinal axons will sprout to fill denervated retinal sites within laminae of the monkey LGN. In 4 monkeys, retinal ganglion cell axons from either the upper or lower half of the retina were destroyed. To maximize the potential for sprouting in the LGN, on one side of the brain the LGN cells to which the remaining retinal axons normally project were removed by ablation of the appropriate portion of the striate cortex. Three months later the eye receiving the retinal lesion was injected with [3H]proline and the retinal projection to the LGN on both sides of the brain was studied using autoradiography. We found no evidence of intralaminar sprouting of retinal axons either in the normal LGN or in the LGN in which the usual targets of retinal axons had been removed.

journal_name

Brain Res

journal_title

Brain research

authors

Stelzner DJ,Keating EG

doi

10.1016/0006-8993(77)90721-1

subject

Has Abstract

pub_date

1977-05-06 00:00:00

pages

201-10

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(77)90721-1

journal_volume

126

pub_type

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