Abstract:
:Proliferative response of astrocytes to unilateral injury of the cerebral hemisphere was investigated in 30-day-old rats using a combination of [3H]thymidine autoradiography and immunocytochemical staining for glial fibrillary acidic protein. At different intervals following injury the animals were injected with [3H]thymidine and the distribution of double-labeled cells was recorded 4 h (short-term experiment) or 40-days (long-term experiment) after each injection. Within the region of the lesion a strong reactive proliferation of astrocytes began as early as 2 h after injury, although, at that time all dividing neuroglial cells were located at a relatively long distance from the lesion margin. Forty days later, however, autoradiographically labeled astrocytes were observed in the center of the lesion. This was regarded as evidence for the ability of astrocytes to migrate towards the site of injury. Maximal reactive proliferation of astroglial cells was observed at day 2 after injury and then reached the postmitotic plateau at about day 8. The cells, while dividing, were mostly GFAP-negative. Therefore, the number of astrocytes produced at particular days after injury, and their contribution to post-traumatic scar formation could be assessed only in the long-term experiment, after the newly formed cells became GFAP-positive.
journal_name
Brain Resjournal_title
Brain researchauthors
Janeczko Kdoi
10.1016/0006-8993(89)90566-0subject
Has Abstractpub_date
1989-04-24 00:00:00pages
236-43issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90566-0journal_volume
485pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Using bilateral infusions into the rat striatum, the effects of the competitive NMDA receptor antagonist 2-amino-5-phosphopentanoic acid (AP5) on behaviors induced by the dopamine (DA) D1 receptor agonist SKF 82526 (fenoldopam) or the D2 receptor agonist quinpirole were determined. These effects were tested in DA-repl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00630-0
更新日期:1996-11-11 00:00:00
abstract::Employing a paired-watering procedure to control for differential fluid intake confounds, adult male rats were exposed in the home cage to water containing 100 ppm cadmium chloride, or a control solution containing no added cadmium chloride. On Day 61 of exposure to their respective watering regimens, half the animals...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01060-2
更新日期:1995-12-08 00:00:00
abstract::A common feature of many neurodegenerative disorders is an abundance of activated glial cells (astrocytes and microglia). In Alzheimer's disease (AD), activated astrocytes are in close apposition to and surrounding the amyloid plaques. The mechanisms by which the astrocytes become activated in AD and the consequences ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01318-8
更新日期:1998-03-02 00:00:00
abstract::The present investigation is aimed at studying the influence of the striate cortex (area 17 or V1) upon responses of area 18a. Electrical activity was recorded from neurons in area 18a through glass micropipettes. At the same time lidocaine hydrochloride was injected in the same retinotopic register of area 17. Forty ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91371-m
更新日期:1990-03-05 00:00:00
abstract::Central catecholamine alterations associated with immune activity are similar to those seen following stressor exposure. Inasmuch as aged animals exhibit more pronounced stressor-provoked alterations of central amines relative to younger animals, it was of interest to determine whether immune challenge would similarly...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90284-4
更新日期:1994-12-12 00:00:00
abstract::Mammalian transglutaminases (TGs) catalyze the irreversible post-translational modifications of proteins, the most prominent of which is the calcium-dependent formation of covalent acyl transfers between the γ-carboxamide group of glutamine and the ε-amino-group of lysine (GGEL-linkage). In the central nervous system,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.11.027
更新日期:2016-01-15 00:00:00
abstract::Recent evidence suggests that cocaine addiction may involve progressive drug-induced neuroplasticity of the dorsal striatum. Here, we examined the effects of a) dorsolateral caudate putamen (dlCPu) lesions on cocaine self-administration, extinction of responding, and subsequent reinstatement to cocaine-seeking, and b)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.08.030
更新日期:2011-10-12 00:00:00
abstract::In rats kainic acid-induced seizures were accompanied by time-dependent cerebral cysteinyl-leukotriene (LT) and prostaglandin (PG) F2 alpha formation. Cysteinyl-LT were identified in the rat brain tissue extracts by their immunoreactive properties and their retention times upon reversed phase HPLC profiling. In perfus...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90579-z
更新日期:1990-05-07 00:00:00
abstract::Neuronal transmission through hippocampal subfields exhibits a high degree of modulation and appears dependent on the behavioral state and hippocampal EEG. Sensory inputs, which profoundly modify the hippocampal EEG, may be involved in modulating hippocampal excitability. Field responses of the CA1 region, evoked by i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90259-4
更新日期:1988-10-04 00:00:00
abstract::We have used the post-embedding immunogold labelling method using antibodies to gamma-aminobutyric acid (GABA) to obtain quantitative data on the distribution, frequency, postsynaptic targets and ultrastructural characteristics of GABA-immunoreactive (GABA-IR) boutons in the trigeminal motor nucleus of rats. We have a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90757-m
更新日期:1991-10-04 00:00:00
abstract::Ciliary ganglion neurons from chick embryo were grown in cell culture following enzymatic and mechanical dissociation. The culture conditions necessary for long-term (greater than 21 days) survival of the isolated neurons were investigated. Neurons could be cultured with and without non-neural cells by adjusting the c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90127-4
更新日期:1980-02-03 00:00:00
abstract::The immunolocalization of the 14-3-3 eta isoform in the anterior horn cells (AHCs) of patients with sporadic amyotrophic lateral sclerosis (ALS) and controls was examined. Compared with the immunolocalization of other 14-3-3 isoforms, the immunolocalization of the 14-3-3 eta isoform was either synaptic at the peripher...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.05.051
更新日期:2016-09-01 00:00:00
abstract::Honokiol, a major bioactive constituent of the bark of Magnolia officinalis has been confirmed to have the neuroprotective effect on ischemic stroke in rats. This study was designed to observe the therapeutic time window of honokiol microemulsion on cerebral ischemia-reperfusion injury to support its potential for fut...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.11.004
更新日期:2013-01-23 00:00:00
abstract::We examined the radical-scavenging activity of docosahexaenoic acid (DHA) and its effects on the neuronal cell death induced by oxidative or hypoxic stress in cultured retinal ganglion cells (RGC-5, a rat ganglion cell-line transformed using E1A virus). The radical-scavenging activity [hydrogen peroxide (H(2)O(2)), su...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.11.031
更新日期:2009-01-28 00:00:00
abstract::It is known that the execution of the motor response in a simple reaction time (RT) task can be delayed by transcranial magnetic stimulation (TMS). This paper is aimed at determining the site of action where the delay in RT occurs. A delay in RT was obtained only at those TMS sites over the motor cortex contralateral ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01062-1
更新日期:1997-01-02 00:00:00
abstract:BACKGROUND:Inflammatory damage aggravates the cerebral ischemic pathological process and may pave a new way for treatment. Bicyclol has been proved to elicit a series of biologic effects through its anti-inflammatory property in treating hepatitis and hepatic ischemic/reperfusion injury. Whether this protective effect ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.06.032
更新日期:2013-08-28 00:00:00
abstract::After traumatic brain injury, extracellular K(+) in brain can dramatically increase. We studied the effects of increased K(+) on the isolated pressurized rat middle cerebral artery (MCA). MCAs (200-250 microm OD) were isolated, cannulated with glass micropipettes, and pressurized. K(+) was increased in the extralumina...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02793-1
更新日期:2000-10-13 00:00:00
abstract::In the dorsal lateral geniculate nucleus (LGN) of the adult cat there is no evidence for translaminar sprouting of retinal axons to fill sites freed of retinal endings from the other eye. We tested the possibility that retinal axons will sprout to fill denervated retinal sites within laminae of the monkey LGN. In 4 mo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90721-1
更新日期:1977-05-06 00:00:00
abstract::The effect of bilateral lesion of the accessory olfactory bulb (AOB) on the mating-induced enhancement of sexual receptivity was investigated in ovariectomized (OVX) female rats. Lesions of the AOB significantly reduced the lordosis-to-mount (L/M) ratio in mating tests conducted 20 to 50 days after the lesion but L/M ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90902-4
更新日期:1994-04-11 00:00:00
abstract::In humans and many other mammalian species, the behavioural consequences of a cortical lesion tend to be milder when it occurs early in life, and there is evidence that an important factor contributing to the behavioural sparing in the young is the formation of new thalamo-cortical connections by thalamic neurons init...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.05.063
更新日期:2007-09-05 00:00:00
abstract::Frequency-modulated (FM) sweeps are important components of most natural sounds. To examine the processing of these stimuli we applied a two-tone paradigm. Repeated stimulus presentation usually leads to reduced neuronal responses. However, in a former study repetition enhancements which have been observed when FM ton...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.07.009
更新日期:2011-09-09 00:00:00
abstract::The purpose of this study was to examine mechanisms involved in the coupling of neuronal activity to cerebral blood flow (CBF). CBF was measured in rat cerebellum using laser-Doppler flowmetry during stimulus-evoked neuronal activity and related to the distribution of the extracellular field potential. Local electrica...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01354-7
更新日期:1996-02-26 00:00:00
abstract::Past research investigating the rostral ventromedial medulla (RVM) in anesthetized animals has found two distinct classes of cells, ON and OFF, noted for their distinct responses to noxious stimuli and to morphine. However, only one class (ON) has been found in the awake animal paradigm. We report in this paper that w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90385-z
更新日期:1993-02-26 00:00:00
abstract::Dynamic microvascular remodeling maintains an optimal continuous supply of oxygen and nutrients to the brain to account for prolonged environmental variations. The objective of this study was to determine the relative time course of capillary regression during re-oxygenation after exposure to prolonged moderate hypoxi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.04.035
更新日期:2014-06-20 00:00:00
abstract::In vivo microdialysis combined with high performance liquid chromatography (HPLC) with electrochemical detection, was used to study the effect of MK-801 (0.1 mg/kg i.p.) on extracellular concentrations of dopamine (DA) 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), norepinephrine (NE) and DOPAC/DA ratio in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02382-4
更新日期:2001-05-25 00:00:00
abstract::Our previous studies demonstrated that only a few days of housing in an enriched environment increases response strength and paired-pulse depression in the auditory cortex of awake and anesthetized rats [Engineer, N.D., Percaccio, C.R., Pandya, P.K., Moucha, R., Rathbun, D.L., Kilgard, M.P., 2004. Environmental enrich...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.062
更新日期:2007-10-12 00:00:00
abstract::Acetylcholinesterase (AChE) histochemical staining occurred in neurons of the dentate gyrus at the day of birth and steadily increased in intensity and distribution during the first 3 postnatal weeks until the adult pattern was reached. Granule cells failed to display AChE staining; however, the somata of most non-pri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90072-1
更新日期:1987-11-01 00:00:00
abstract::Administration of methyl palmoxirate (MP), an inhibitor of fatty acid oxidation, stimulates eating behavior in rats. Fos immunohistochemistry was used to determine neural pathways that may play a role in the eating response to MP. The number of cells showing Fos-like immunoreactivity (Fos-li) was quantified by compute...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01143-8
更新日期:1998-01-19 00:00:00
abstract::The responses of single alpha motoneurons to various "natural' stimuli were recorded from dissected ventral root filaments in lightly anesthetized control and recently decerebellate cats. The identity of the motoneurons was established by recording the unitary responses to orthodromic stimulation of nerves innervating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90208-5
更新日期:1975-09-12 00:00:00
abstract::To evaluate roles of the sympathetic nervous system in enhancing glucose uptake in skeletal muscles in response to electrical stimulation of the ventromedial hypothalamic nucleus (VMH), the effects of guanethidine treatment and adrenal demedullation on the response were examined in rats anesthetized and injected with ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91085-5
更新日期:1994-06-27 00:00:00