Abstract：
:Recent evidence suggests that cocaine addiction may involve progressive drug-induced neuroplasticity of the dorsal striatum. Here, we examined the effects of a) dorsolateral caudate putamen (dlCPu) lesions on cocaine self-administration, extinction of responding, and subsequent reinstatement to cocaine-seeking, and b) reversible inactivation of the dlCPu with GABA receptor agonists (baclofen and muscimol) immediately prior to reinstatement testing. Male, Sprague-Dawley rats self-administered cocaine (0.2mg/50μl infusion, i.v.) along an FR1 schedule in daily 2h sessions for 10days, whereby lever presses resulted in cocaine infusions and presentation of a paired light-tone stimulus complex. After 14days of abstinence, animals were returned to the self-administration chamber and lever responding was recorded, but had no programmed consequences (relapse test). Animals then underwent daily extinction, followed by reinstatement tests in the presence of the conditioned cues, after a cocaine priming injection (10mg/kg), or cues+cocaine prime. Lesions of the dlCPu failed to affect responding during self-administration, extinction, relapse, or cued-induced reinstatement. However, lesioned animals showed reduced cocaine-seeking during cocaine-primed reinstatement as compared to sham controls. Furthermore, reversible inactivation of the dlCPu significantly impaired both cocaine-primed and cocaine-primed+cue-induced reinstatement. These results demonstrate the critical involvement of the dlCPu in cocaine-primed reinstatement, perhaps via chronic drug-induced changes in the interoceptive effects of cocaine that impact drug-seeking.
journal_name
Brain Resjournal_title
Brain researchauthors
Gabriele A,See REdoi
10.1016/j.brainres.2011.08.030subject
Has Abstractpub_date
2011-10-12 00:00:00pages
27-35eissn
0006-8993issn
1872-6240pii
S0006-8993(11)01535-6journal_volume
1417pub_type
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