Abstract：
:A substantial number of patients do not respond sufficiently to antidepressant drugs and are therefore often co-medicated with lithium as an augmentative strategy. Since lithium has been demonstrated to affect 5-HT neurotransmission, we examined the effect of acute and subchronic lithium on 5-HT levels after a challenge with citalopram. We found that subchronic administration of lithium increases extracellular 5-HT baseline level and decreases the extracellular 5-HIAA baseline. However, we found no evidence that the effect of acute citalopram on extracellular 5-HT levels is augmented by acute or subchronic lithium.
journal_name
Brain Resjournal_title
Brain researchauthors
Wegener G,Linnet K,Rosenberg R,Mørk Adoi
10.1016/s0006-8993(00)02461-6subject
Has Abstractpub_date
2000-07-21 00:00:00pages
338-42issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02461-6journal_volume
871pub_type
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