Abstract：
:The lateral hypothalamus (LH) is a site of integration for control mechanisms of feeding behavior as it has extensive reciprocal connections with multiple intrahypothalamic and extrahypothalamic brain areas. Evidence suggests that blockade of ionotropric gamma-aminobutyric acid (GABA) receptors in the LH elicits eating in satiated rats. To determine whether this GABA(A) receptor antagonist effect is specific to the LH, the antagonist picrotoxin was injected into one of six nearby sites and food intake was measured. Picrotoxin at 133 pmol elicited eating in the LH, but not in surrounding sites (thalamus, lateral preoptic area, ventral tegmental area, dorsomedial hypothalamus, and entopeduncular nucleus). More specifically, picrotoxin injected into the tuberal LH (tLH) elicited eating, but was ineffective when injected into the anterior or posterior LH. We also investigated whether GABA(B) receptors in the LH participated in the control of food intake and found that neither blockade nor activation of these receptors under multiple conditions changed food intake. Collectively, our findings suggest that GABA(A) but not GABA(B) receptors in the tLH act to suppress feeding behavior.
journal_name
Brain Resjournal_title
Brain researchauthors
Turenius CI,Charles JR,Tsai DH,Ebersole PL,Htut MH,Ngo PT,Lara RN,Stanley BGdoi
10.1016/j.brainres.2009.05.064subject
Has Abstractpub_date
2009-08-04 00:00:00pages
65-72eissn
0006-8993issn
1872-6240pii
S0006-8993(09)01128-7journal_volume
1283pub_type
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