Abstract：
:The principal thalamic and hypothalamic structures implicated in mnemonic information processing are the mediodorsal nucleus of the thalamus, the pulvinar, anterior thalamus, and laterodorsal nucleus, the mamillary body, and the mamillothalamic tract and internal medullary lamina. Determining the contribution of an individual region in memory is quite difficult as it is nearly impossible to find a circumscribed damage of only one region. On the contrary, some illnesses affecting primarily the diencephalon, such as Korsakoff's disease, tend to involve several structures together. Furthermore, even when cases with similar circumscribed diencephalic damage can be found, these will not necessarily demonstrate the same outcome on the behavioral level. Therefore, the role or contribution of individual memory-related diencephalic structures has to be inferred by comparing a number of cases and by then extracting distinct features common to a given group. Such an approach revealed that the contributions of the two fiber systems mentioned above, mamillothalamic tract and internal medullary lamina, might be more important in processing information long-term than had been acknowledged previously and might be more important than that of the nuclear masses mentioned, especially of the mediodorsal thalamus. This outcome underlines the view that emphasizing interactions between brain regions rather than single static masses will provide a more realistic picture of how the nervous system acts in information processing.
journal_name
Brain Resjournal_title
Brain researchauthors
Markowitsch HJdoi
10.1016/0006-8993(88)91226-7subject
Has Abstractpub_date
1988-12-01 00:00:00pages
351-70issue
4eissn
0006-8993issn
1872-6240pii
0006-8993(88)91226-7journal_volume
472pub_type
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