Abstract：
:Mammalian neostriatum is composed of two neurochemically and neuroanatomically defined compartments, called the patches and matrix. The present study concerns a search for neurochemical molecules involved in formation of the striatal compartments. Using the monoclonal antibody CR-50, we here disclose a transient expression of the reeler gene product Reelin, which is known to play a crucial role in neuronal positioning and axon guidance during corticogenesis, in the developing striatum of rats. Furthermore, Reelin protein is differentially concentrated in the two distinct compartments showing a mosaic-like fashion in the early postnatal period: the compartments of heightened CR-50-immunolabeling correspond to so-called "dopamine islands" (i.e., developing striosomes) visualized by tyrosine hydroxylase (TH)-immunostaining. On the basis of these findings, we hypothesize that Reelin protein may play a role in developmental organization of the striatal compartments.
journal_name
Brain Resjournal_title
Brain researchauthors
Nishikawa S,Goto S,Hamasaki T,Ogawa M,Ushio Ydoi
10.1016/s0006-8993(99)02136-8subject
Has Abstractpub_date
1999-12-11 00:00:00pages
244-8issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02136-8journal_volume
850pub_type
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