The N-methyl-D-aspartate antagonist MK-801 protects against serotonin depletions induced by methamphetamine, 3,4-methylenedioxymethamphetamine and p-chloroamphetamine.

abstract：:We have attempted to identify some novel genes which were found to be more highly expressed in the embryonic brain than in the adult brain. Consequently, one of these clones was identified as alpha-globin cDNA. Actually, alpha-globin mRNA was detected in the neurons. In addition, beta-globin mRNA was detected in the n...

journal_title：Brain research

authors： Ohyagi Y,Yamada T,Goto I

更新日期：1994-01-28 00:00:00

abstract：:The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in...

journal_title：Brain research

authors： Wachi M,Okuda M,Togashi S,Fuwano S,Miyashita O

更新日期：1985-05-06 00:00:00

abstract：:Music is an intriguing stimulus widely used in movies to increase the emotional experience. However, no brain imaging study has to date examined this enhancement effect using emotional pictures (the modality mostly used in emotion research) and musical excerpts. Therefore, we designed this functional magnetic resonanc...

journal_title：Brain research

authors： Baumgartner T,Lutz K,Schmidt CF,Jäncke L

更新日期：2006-02-23 00:00:00

abstract：:Mesencephalic dopamine neurons form synapses with acetylcholine (ACh)-containing interneurons in the nucleus accumbens (NAcc). Although their involvement in drug reward has not been systematically investigated, these large aspiny interneurons may serve an important integrative function. We previously found that repeat...

journal_title：Brain research

authors： Mark GP,Kinney AE,Grubb MC,Zhu X,Finn DA,Mader SL,Berger SP,Bechtholt AJ

更新日期：2006-12-06 00:00:00

abstract：:Microinjection of cholinergic agonists into the pontine tegmentum was used to evoke a state which was polygraphically and behaviorally similar to desynchronized (D) sleep. This study was designed to test the hypothesis that the production of this pharmacologically induced D sleep-like state (D-ACh) was dependent upon ...

journal_title：Brain research

authors： Baghdoyan HA,Rodrigo-Angulo ML,McCarley RW,Hobson JA

更新日期：1987-06-30 00:00:00

abstract：:Brain edema is a serious consequence of hemispheric stroke and traumatic brain injury and contributes significantly to patient mortality. In the present study, we measured water contents in hippocampal slices as an in vitro model of edema formation. Excitotoxic conditions induced by N-methyl-D-aspartate (NMDA, 300 mic...

journal_title：Brain research

authors： Kumar V,Naik RS,Hillert M,Klein J

更新日期：2006-11-29 00:00:00

abstract：:The effects of dopamine on glutamate-induced cytotoxicity were examined using the primary cultures of rat striatal neurons. Cell viability was significantly reduced by exposure of cultures to glutamate or kainate for 24 h. In contrast, similar application of N-methyl-D-aspartate (NMDA) or alpha-amino-3-hydroxy-5-methy...

journal_title：Brain research

authors： Amano T,Ujihara H,Matsubayashi H,Sasa M,Yokota T,Tamura Y,Akaike A

更新日期：1994-08-29 00:00:00

abstract：:In the present study, we performed immunohistochemical studies to investigate the changes of Bcl-2 and Bax in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation. In contrast to the controls, a high density of Bcl-2-IR astrocytes were detected all around the gray matter of the spina...

journal_title：Brain research

authors： Shin CM,Chung YH,Kim MJ,Shin DH,Kim YS,Gurney ME,Lee KW,Cha CI

更新日期：2000-12-29 00:00:00

abstract：:The importance of particular genes in neuronal death following global cerebral ischemia can readily be studied in genetically modified mice provided a reliable model of ischemia is available. For that purpose, we developed a mouse model of global cerebral ischemia that induces consistent damage to different regions of...

journal_title：Brain research

authors： Olsson T,Wieloch T,Smith ML

更新日期：2003-08-29 00:00:00

abstract：:The cellular mechanism for the suppression of GnRH gene expression by the phorbol ester PMA was investigated in GT1 cells. The protein synthesis inhibitor cycloheximide decreased GnRH primary transcript levels, indicating a protein synthesis requirement for basal GnRH transcription. PMA decreased GnRH primary transcri...

journal_title：Brain research

authors： Yeo TT,Gore AC,Blum M,Roberts JL

更新日期：1997-03-28 00:00:00

abstract：:The mechanism of the Ca2+-dependent stimulation of neurotransmitter release by 4-aminopyridine in synaptosomes was studied. The stimulation of gamma-[3H]aminobutyric acid and [3H]acetylcholine release by 4-aminopyridine was not significantly affected either by tetrodotoxin or by the absence of Na+ in the medium, where...

journal_title：Brain research

authors： Tapia R,Sitges M,Morales E

更新日期：1985-12-30 00:00:00

abstract：:Brain injury accelerates amyloid-β (Aβ) deposits and exacerbates Alzheimer's disease (AD). Accumulation of intracellular soluble Aβ impairs cognition prior to emergence of Aβ plaques. However, it is not known whether brain injury affects learning impairment attributable to intracellular soluble Aβ. We made a small inj...

journal_title：Brain research

authors： Zou J,Wang M,Uchiumi O,Shui Y,Ishigaki Y,Liu X,Tajima N,Akai T,Iizuka H,Kato N

更新日期：2016-04-15 00:00:00

abstract：:We have developed a novel imaging system "real-time bioradiography", which is able to estimate the dynamic changes of physiological function and metabolism in living tissues using positron emitter-labeled tracers and chemiluminescence probes. The apparatus is comprised of a photon-counting camera, image-controller, cu...

journal_title：Brain research

authors： Sasaki T,Iwamoto A,Tsuboi H,Watanabe Y

更新日期：2006-03-10 00:00:00

abstract：:Glutamate is a major neurotransmitter in the CNS. Its release activates NMDA and non-NMDA receptors on the postsynaptic membrane. NMDA receptor activation is shown to be important in physiological and pathological events. The modulatory sites on the NMDA receptor-channel ionophore complex are important in the regulati...

journal_title：Brain research

authors： Saybasili H

更新日期：1998-03-09 00:00:00

abstract：:Increased and sustained central delivery of L-dihydroxyphenylalanine (L-DOPA) is a desirable therapeutic strategy in Parkinson's disease. We investigated the effects of peripheral catechol-O-methyltransferase (COMT) inhibition, by the non-toxic drug nitecapone on the metabolism of 6-[18F]fluoro-L-dihydroxyphenylalanin...

journal_title：Brain research

authors： Miletich RS,Comi G,Bankiewicz K,Plunkett R,Adams R,Di Chiro G,Kopin IJ

更新日期：1993-10-29 00:00:00

abstract：:Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...

journal_title：Brain research

authors： Read SJ,Parsons AA

更新日期：2000-07-07 00:00:00

abstract：:Recent studies, which have shown an increase of plasma vasopressin (VP) in experimental motion sickness and the efficacy of VP antagonists for motion sickness, suggest an important role of VP in the development of vestibulo-autonomic responses. We have recently found evidence of the co-existence of vasopressinergic ne...

journal_title：Brain research

authors： Horii A,Koike K,Uno A,Uno Y,Kubo T

更新日期：2001-09-28 00:00:00

abstract：:Previous evidence suggests that preterm newborns with intrauterine growth restriction (IUGR) have specific neurostructural and neurodevelopmental anomalies, but it is unknown whether these effects persist in early childhood. We studied a sample of 18 preterm IUGR, 15 preterm AGA - born between 26 and 34 weeks of gesta...

journal_title：Brain research

authors： Padilla N,Falcón C,Sanz-Cortés M,Figueras F,Bargallo N,Crispi F,Eixarch E,Arranz A,Botet F,Gratacós E

更新日期：2011-03-25 00:00:00

abstract：:Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is sp...

journal_title：Brain research

authors： Vanĕcek J,Vollrath L

更新日期：1989-12-25 00:00:00

abstract：:The lateral tuberal nucleus (LTN) is a hypothalamic region that has been identified with certainty only in humans and primates. It is composed of three small round globular units which protrude the basal surface of the brain along the optic tract. The function of the LTN is unknown. Recently, a tiny, parvalbumin-posit...

journal_title：Brain research

authors： Gerig AT,Celio MR

更新日期：2007-03-30 00:00:00

abstract：:Chronic food restriction lowers the threshold for lateral hypothalamic electrical self-stimulation (LHSS). This effect has previously been interpreted to reflect a sensitization of reward. In the present study a curve-shift method was used to explicitly differentiate effects of food restriction on brain stimulation re...

journal_title：Brain research

authors： Abrahamsen GC,Berman Y,Carr KD

更新日期：1995-10-16 00:00:00

abstract：:In this paper we report on the effects of intra-VTA infusion of opioid agonists on rat ingestive behavior in a variety of experimental contexts. When the animals were tested outside of their home cages surrounded only by food-pellets (Experiment 1), the injection of the mu-opioid agonist DAMGO, but not the kappa-opioi...

journal_title：Brain research

authors： Badiani A,Leone P,Noel MB,Stewart J

更新日期：1995-01-30 00:00:00

abstract：:Stimulation of a region within the parvocellular medullary reticular formation (PcRF) that contains somas of premotor interneurons produces short latency inhibitory synaptic potentials (IPSPs) in cat trigeminal motoneurons. The present study was undertaken to determine whether glycinergic synapses are responsible for ...

journal_title：Brain research

authors： Castillo P,Pedroarena C,Chase MH,Morales FR

更新日期：1991-12-20 00:00:00

abstract：:This ERP study explores the brain's response to the manipulation of motor compatibility in action-related language. In Experiment 1 participants read sentences in which a protagonist performed two different manual actions either simultaneously or consecutively (e.g. While/after cleaning the wound he unrolled the banda...

journal_title：Brain research

authors： Santana EJ,de Vega M

更新日期：2013-08-14 00:00:00

abstract：:The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...

journal_title：Brain research

authors： Hosoi R,Kitano D,Momosaki S,Kuse K,Gee A,Inoue O

更新日期：2010-01-22 00:00:00

abstract：:Glucagon like peptide-1 (7-36) amide (GLP-1), a potent regulator of glucose homeostasis, is also produced in the central nervous system and has been implicated in the control of hypothalamic-pituitary function and food intake. GLP-1 immunoreactive (IR) fibers and terminals are widely distributed in the septum, hypotha...

journal_title：Brain research

authors： Sarkar S,Fekete C,Légrádi G,Lechan RM

更新日期：2003-09-26 00:00:00

abstract：:Initial studies found glutamate injury to murine spinal cultures (14-17 days in vitro) to reflect contributions of both NMDA and AMPA/kainate receptors. Subsequent experiments found the spinal cultures to be more sensitive than cortical cultures to injury from prolonged low level kainate exposures, and, unlike cortica...

journal_title：Brain research

authors： Yin HZ,Park DD,Lindsay AD,Weiss JH

更新日期：1995-08-21 00:00:00

abstract：:A major function of the dopamine in the striatum is to control the activity of its efferent systems which contain primarily GABAergic neurons. Direct intracerebral injections of haloperidol into the corpus striatum impaired the performance of rats trained to depress a lever in a sensitive reaction time task. Rats were...

journal_title：Brain research

authors： Amalric M,Koob GF

更新日期：1989-04-03 00:00:00

abstract：:Myelin-associated glycoprotein (MAG) is susceptible to proteolysis by a calcium-activated neutral protease which is located in myelin. The conversion of MAG (M(r) 100,000) to its soluble derivative dMAG (M(r) 90,000) occurs much more rapidly in myelin from human white matter than in myelin from rat brain, and the rate...

journal_title：Brain research

authors： Möller JR

更新日期：1996-11-25 00:00:00

abstract：:It is known that the execution of the motor response in a simple reaction time (RT) task can be delayed by transcranial magnetic stimulation (TMS). This paper is aimed at determining the site of action where the delay in RT occurs. A delay in RT was obtained only at those TMS sites over the motor cortex contralateral ...

journal_title：Brain research

authors： Ziemann U,Tergau F,Netz J,Hömberg V

更新日期：1997-01-02 00:00:00