Abstract：
:Glutamate is a major neurotransmitter in the CNS. Its release activates NMDA and non-NMDA receptors on the postsynaptic membrane. NMDA receptor activation is shown to be important in physiological and pathological events. The modulatory sites on the NMDA receptor-channel ionophore complex are important in the regulation of the channel's cation conductance. Regulation of the channel by proton concentration may be important in the alkalinization that occurs during the normal release of glutamate or in the acidification that occurs during hypoxia/ischemia. In this study, the selective downregulation of the NMDA channel with slight extracellular pH changes and reversibility of this modulation have been shown in hippocampal slices. It has also been shown that hippocampal slices are more responsive to pH changes than other experimental preparations. The downregulation of the NMDA current may represent a native control mechanism. Direct and indirect modulation caused by extracellular pH changes on the NMDA receptor ionophore complex might be important in the overall response of the neuron under pathophysiological changes.
journal_name
Brain Resjournal_title
Brain researchauthors
Saybasili Hdoi
10.1016/s0006-8993(97)01461-3subject
Has Abstractpub_date
1998-03-09 00:00:00pages
128-32issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01461-3journal_volume
786pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The purpose of this study was to investigate morphological characteristics of the synaptic relations of choline acetyltransferase (ChAT)-positive terminals that are made with a variety of post-synaptic profiles in the lateralis medialis-suprageniculate nuclear complex (LM-Sg) using ChAT, gamma-aminobutyric acid (GABA)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01208-5
更新日期：1997-01-30 00:00:00
abstract：:Immunohistochemical studies of a peroxisomal enzyme, bifunctional protein, were performed on human brains (occipital cortex, cerebellum, pons) from fetus to young adult. Bifunctional protein-positive neurons appeared at 23-25 weeks of gestation in the facial nuclei of pons, at 27-28 weeks in the occipital cortex and P...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91878-3
更新日期：1994-03-21 00:00:00
abstract：:Amphetamine-induced locomotion and stereotypy were concurrently evaluated in order to determine if pretreatment with para-chlorophenylalanine (PCPA) (which is reported to facilitate some of the effects of amphetamine) results in a behavioral pattern similar to the augmentation previously reported to occur with repeate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90904-5
更新日期：1976-11-05 00:00:00
abstract：:The distributions of neurotensin and opiate receptors within the dorsal horn of the rat spinal cord were studied with quantitative autoradiographic techniques and compared with the immunohistochemical localizations of neurotensin and methionine-enkephalin-like immunoreactivity in this region. High densities of both ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90395-4
更新日期：1981-12-28 00:00:00
abstract：:Previous work has shown a relatively high turnover of adrenaline in the mediobasal hypothalamus during the critical period (15.00-17.00 h) of the proestrous rat. We now report that this high level of adrenergic activity can be detected in the median eminence (turnover rate 1.62 +/- 0.36 pg/micrograms protein/h) rather...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90307-x
更新日期：1984-12-10 00:00:00
abstract：:The intermediate, medial part of the hyperstriatum ventrale (IMHV) is an area of the avian forebrain which is essential for two forms of early learning in the domestic chick. We have developed an in vitro slice preparation which contains part of the IMHV and have found that the electrophysiological properties of the a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00361-7
更新日期：1996-07-15 00:00:00
abstract：:The development of the dorsal root potential (DRP) and the responsiveness of primary afferent fibers to gamma-aminobutyric acid (GABA) were investigated in the isolated spinal cord of rat fetuses. At embryonic day 15.5, stimulation of the lumbar dorsal root was first effective in eliciting the DRP, which was not inhib...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90127-0
更新日期：1985-01-01 00:00:00
abstract：:Our study aimed to explore the influence of two different stressors: acute (once for 15 min) and chronic (15 min daily for 21 days) exposure to high light open field (HL-OF) or forced swim (FS) on the density of nerve growth factor (NGF) and tyrosine kinase A (TrkA) immunoreactive neurons in the hippocampal CA1 and CA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.112
更新日期：2011-04-12 00:00:00
abstract：:The present study describes the time course of recovery in the fast axonal transport of 3H-labeled proteins in the nerve and the electrophysiological parameters in the extensor muscle of rats after single subperineural injection of batrachotoxin (BTX) (9.3 x 10(-12) mol) into the peroneal nerve. The fast axonal transp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90322-x
更新日期：1981-11-23 00:00:00
abstract：:The recruitment of performance control was recently explained in terms of the detection of response conflict. One recent hypothesis claims that the degree of response conflict is reflected in an electroencephalographical component, the Error Negativity (Ne). Indeed, in the framework of simulations, variations of the N...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.004
更新日期：2006-06-20 00:00:00
abstract：:Recent neurocognitive studies of visual word recognition provide information about neuronal networks correlated with processes involved in lexical access and their time course (e.g., [Holcomb, Ph.J., Grainger J. and O'Rourke, T. (2002). An Electrophysiological Study of the Effects of Orthographic Neighborhood Size on ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.078
更新日期：2006-02-16 00:00:00
abstract：:The prostacyclin (PGI2) formation in cerebral vessels, as reflected by the difference in concentration of internal carotid arterial and internal jugular venous radioimmunoassayed 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), was determined under normocapnic and hypercapnic conditions in 5 patients with mild cereb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91272-6
更新日期：1983-01-24 00:00:00
abstract：:In order to explore the anatomical nature of the inhibitory GABAergic control of cerebral serotonergic neurons exerted at the level of the anterior raphé cells in the rat, we have studied the effect of GABA agonist agents (given systemically or infused locally into the raphé dorsalis or medianus) on cerebral 5-hydroxy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90717-6
更新日期：1985-04-01 00:00:00
abstract：:Iontophoresis of baclofen produced hyperpolarization and a decrease in input resistance in 32 neurons and no effect in 24 neurons of the ventral respiratory group in cats. Iontophoresed phaclofen antagonized the effect of baclofen, but had negligible effects on periodic fluctuations in membrane potential and spike act...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90832-8
更新日期：1993-09-17 00:00:00
abstract：:A positive association between cardiorespiratory fitness (CRF) and white matter integrity has been consistently reported in older adults. However, it is unknown whether this association exists in adults over 80 with a range of chronic disease conditions and low physical activity participation, which can influence both...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.003
更新日期：2014-11-07 00:00:00
abstract：:Patches of transnueronal degeneration were produced in the lateral geniculate nucleus (LGN) by retinal laser burns and a tarsorrhaphy was performed in the contralateral eye of Macaca mulatta during infancy. The adverse effect of unilateral visual deprivation on geniculate cell growth was absent in those portions of de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90772-1
更新日期：1976-07-30 00:00:00
abstract：:Rats with 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway show enhanced locomotor and stereotyped behaviors when challenged with direct and indirect dopamine (DA) agonists due to the development of postsynaptic supersensitivity. To determine if this phenomenon generalizes to other motor behaviors, we h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02753-0
更新日期：2000-10-06 00:00:00
abstract：:Glutamate N-methyl-D-aspartate receptors (NMDARs) in the medial prefrontal cortex (mPFC) and hippocampus may play an integral role in complex cognitive and social deficits associated with a number of psychiatric illnesses including autism, mood disorders, and schizophrenia. We used localized infusions of adeno-associa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.037
更新日期：2015-03-10 00:00:00
abstract：:Previous studies have shown that access to conceptual/semantic information precedes phonological access in alphabetic language production such as English or Dutch. The present study investigated the time course of semantic and orthographic encoding in Chinese (a non-alphabetic language) spoken word production. Partici...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.03.049
更新日期：2009-06-01 00:00:00
abstract：:Application of 4-aminopyridine (4-AP) has previously been reported to produce different patterns of epileptiform discharges in entorhinal cortex (EC)-hippocampal slices: recurrent short discharges (RSDs) in hippocampal area CA1, seizure-like events (SLEs) and negative-going potentials (NGPs) in the medial entorhinal c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02348-3
更新日期：2000-03-17 00:00:00
abstract：:Altered dopamine regulation in the medial prefrontal cortex has been linked to drug abuse and disorders such as schizophrenia. Heterogeneous expression of the dopamine transporter, as well as the ability of the norepinephrine transporter to clear dopamine in the prefrontal cortex, delineates two potential sites for th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02542-8
更新日期：2002-05-17 00:00:00
abstract：:The parabrachial nucleus consists of several subnuclei which contains autonomic, gustatory, visceral sensory, nociceptive, and respiratory related neurons. We have investigated the direct projections from the rat parabrachial region, including the K olliker-Fuse nucleus, to the pharyngeal motoneurons with an anterogra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01127-5
更新日期：1999-01-23 00:00:00
abstract：:Using mild heat shock of rat brain slices as a model for cellular insult, corticosteroid-mediated regulation of protein synthesis has been investigated. Following a single in vivo injection of rats with corticosterone or the Type II glucocorticoid receptor agonist, RU-28362, synthesis of a 28 kDa protein is elevated i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01988-5
更新日期：1999-11-13 00:00:00
abstract：:In a focused attention task saccadic reaction time (SRT) to a visual target stimulus (LED) was measured with an auditory (white noise burst) or tactile (vibration applied to palm) nontarget presented in ipsi- or contralateral position to the target. Crossmodal facilitation of SRT was observed under all configurations ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.081
更新日期：2008-11-25 00:00:00
abstract：:6-[18F]Fluoro-L-DOPA (FDOPA) is an imaging agent used in the study of dopamine terminals in the living brain using positron emission tomography (PET). To better understand the role of tracer metabolism in dynamic FDOPA PET studies, the pharmacokinetics of individual FDOPA metabolites in extracellular space in the stri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02649-4
更新日期：2000-09-15 00:00:00
abstract：:Preconditioning describes a variety of treatments that induce neurons to become more resistant to a subsequent ischemic insult. How preconditioned neurons adapt to subsequent ischemic stress is not fully understood, but is likely to involve multiple protective mechanisms. We hypothesized hypoxic preconditioning induce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.05.031
更新日期：2004-08-13 00:00:00
abstract：:Fluctuation analysis has been used to study the influence of temperature on the conductance and mean open time of Cl- permeable ion channels induced by gamma-aminobutyric acid (GABA) and glycine in the membrane of tissue cultured mouse spinal neurons. The conductance of GABA- and glycine-activated channels increased s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90875-1
更新日期：1981-11-16 00:00:00
abstract：:Male and female hooded rats were raised from weaning in either a complex or an isolated environment in two separate replications. After one month, the brains were Golgi-Cox stained and dendritic fields of dentate gyrus granule cells were quantified. There was a sex difference in response to the environment. Females ra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90125-8
更新日期：1985-04-29 00:00:00
abstract：:Swelling of glial and nerve cells is characteristic of brain damage in cerebral ischemia or trauma. The therapeutical efficiency of inhibition of Cl(-)-transport by a novel antagonist, the diuretic torasemide, on cytotoxic swelling of glial cells from lactacidosis, or glutamate was analyzed. Lactacidosis and the inter...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91218-h
更新日期：1993-04-30 00:00:00
abstract：:A subset of olfactory receptor neurons of the Caribbean spiny lobster Panulirus argus possesses receptors for L-glutamate that can mediate both excitatory and inhibitory responses (P.C. Daniel, M.F. Burgess, C.D. Derby, Responses of olfactory receptor neurons in the spiny lobster to binary mixtures are predictable usi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00816-0
更新日期：1997-10-17 00:00:00
