Abstract:
:Glutamate N-methyl-D-aspartate receptors (NMDARs) in the medial prefrontal cortex (mPFC) and hippocampus may play an integral role in complex cognitive and social deficits associated with a number of psychiatric illnesses including autism, mood disorders, and schizophrenia. We used localized infusions of adeno-associated virus Cre-recombinase in adult, targeted knock-in mice with loxP sites flanking exons 11-22 of the NR1 gene to investigate the effects of chronic NMDAR dysfunction in the mPFC and CA3 hippocampus on cognitive and social behavior. A 5-choice serial reaction time task (5-CSRTT) was used to monitor aspects of cognitive function that included attention and response inhibition. Social behavior was assessed using Crowley׳s sociability and preference for social novelty protocol. Chronic NMDAR dysfunction localized to the anterior cingulate/prelimbic mPFC or dorsal CA3 hippocampus differentially affected the response inhibition and social interaction. mPFC NR1-deletion increased perseverative responding in the 5-CSRTT and enhanced preference for social novelty, whereas CA3 NR1-deletion increased premature responding in the 5-CSRTT and decreased social approach behavior. These findings suggest that mPFC and CA3 NMDARs play selective roles in regulating compulsive and impulsive behavior, respectively. Furthermore, these findings are consistent with emerging evidence that these behaviors are mediated by distinct, albeit overlapping, neural circuits. Our data also suggest that NMDARs in these regions uniquely contribute to the expression of normal social behavior. In this case, mPFC and CA3 NMDARs appear to inhibit and facilitate aspects of social interaction, respectively. The latter dissociation raises the possibility that distinct circuits contribute to the expression of social intrusiveness and impoverished social interaction.
journal_name
Brain Resjournal_title
Brain researchauthors
Finlay JM,Dunham GA,Isherwood AM,Newton CJ,Nguyen TV,Reppar PC,Snitkovski I,Paschall SA,Greene RWdoi
10.1016/j.brainres.2014.10.037subject
Has Abstractpub_date
2015-03-10 00:00:00pages
70-83eissn
0006-8993issn
1872-6240pii
S0006-8993(14)01439-5journal_volume
1600pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Subtypes of muscarinic receptors were characterized in the frontal cortices of control and Alzheimer brains, with labelled quinuclidinyl benzilate [3H]QNB and the unlabelled muscarinic antagonists pirenzepine, AF-DX 116, hexahydro-sila-diphenidol (HHSiD), para-fluoro-hexahydro-sila-diphenidol (p-F-HHSiD) and himbacine...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91541-l
更新日期:1992-11-20 00:00:00
abstract::It has been hypothesized on the basis of animal models of epilepsy that abnormal neural activity in epilepsy may be related to reorganized neural circuits that facilitate epileptogenesis. Little evidence of this was available for human epilepsy. This paper provides the first evidence of such reorganization of a hippoc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90234-5
更新日期:1989-08-28 00:00:00
abstract::Quantitative autoradiographic analysis was used to identify regions in the brain of the male primate where androgen binding sites may be involved in the actions of testosterone. Three days after castration, adult male rhesus monkeys received a subcutaneous injection of either dihydrotestosterone propionate (DHTP, 20 m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90456-3
更新日期:1989-11-13 00:00:00
abstract::To learn whether there are developmental changes in salt and acid taste responses from the posterior tongue, we recorded from the glossopharyngeal nerve, which innervates taste buds in circumvallate papillae, in sheep fetuses, lambs and adults. Multifiber responses to NH4Cl, KCl, NaCl, LiCl, citric and hydrochloric ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90205-5
更新日期:1983-12-01 00:00:00
abstract::One optic nerve of mature goldfish was crushed in the orbit and allowed to regenerate. During regeneration impulse activity was eliminated by periodic intraocular injections of tetrodotoxin (TTX). At 32-104 days, the retinotopography of the retinotectal projection was measured autoradiographically by intraocular [3H]p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90068-8
更新日期:1983-02-01 00:00:00
abstract::The enzymes catalyzing the breakdown of TRH are soluble and dependent upon active sulfhydryl groups. One of these enzymes is a pyroglutamyl aminopeptidase (EC 3.4.11.8) (apparent molecular weight 60,000 daltons) with a specificity restricted to pyroglutamyl peptide bonds. The second enzyme is a prolyl endopeptidase (a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90309-2
更新日期:1982-06-24 00:00:00
abstract::Nissl cytoarchitectural and MAP-2 immunocytochemical evidence is presented for the radial organisation of neurons and neural processes in the human medial prefrontal cortex (mPFC). In Brodmann areas 25, 32, and 32', neuronal cell bodies are organised into short vertical stacks of 15-19 somata with pyramidal cells apic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.08.054
更新日期:2003-12-05 00:00:00
abstract::Strychnine-sensitive glycine receptors (GlyR) play a major role in the excitability of CNS neurons and are also a major target of many drugs including some general anesthetics and ethanol. The prefrontal cortex (PFC) is an important substrate responsible for cognitive function and for sedation, as well as hypnosis (un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.03.073
更新日期:2011-06-01 00:00:00
abstract::Our previous study [32] indicated that blockade of kappa-opioid receptors with nor-binaltorphimine (nor-BNI) in the medial preoptic area (MPOA) produced two different LH responses during midpregnancy in the rat: an increase in basal pulsatile LH secretion, followed in many cases by a larger and/or sustained increase i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00874-p
更新日期:1995-11-06 00:00:00
abstract::By using the modified detection method, favored patterns can be detected in a total of 44 spontaneous spike trains. Among these the 'periodical burst' discharge of one sympathetic preganglionic neuron and the 'fast-slow' alternative discharge of some hypothalamic neurons have visible characteristics, hence we use them...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90008-j
更新日期:1991-09-20 00:00:00
abstract::The lamination of the hippocampus in the homozygous B6CBA weaver mouse (wv/wv) was compared with that in normal B6CBA littermates (+/+) and C57BL/6J mice using Nissl and Timm's staining. In Nissl-stained preparations, the normal littermates exhibit a compact, regular arrangement of pyramidal cells in area CA3 of the h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00974-u
更新日期:1995-10-23 00:00:00
abstract::Microtubule-stabilizing drugs are useful in cancer therapy and show promise for treatment of neurodegenerative diseases. An overlapping binding site between tau and taxoid site drugs has led to a number of research papers investigating the competitive interaction between these drugs and the microtubule. This has impli...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.10.022
更新日期:2012-12-13 00:00:00
abstract::We identified the burst and single-spiking cells, and the repetitive bursting cells in layers III and V of the cat sensorimotor cortex with intracellular recording and staining techniques. Both types of the bursting cells were found in 22.7% of the recorded layer V neurons and in 23.1% of the recorded neurons in layer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00505-7
更新日期:1996-07-15 00:00:00
abstract::Thyrotropin-releasing hormone (TRH) immunoreactivity in rat tissue was assayed using a new reversed-phase, ion-pair, high-pressure liquid chromatography (HPLC) method for separating TRH from its analogs. Virtually all of the TRH immunoreactivity in hypothalamus, brain stem, preoptic area, septum, striatum, frontal cor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91036-7
更新日期:1980-11-17 00:00:00
abstract::The number of hypocretin-containing neurons is markedly decreased in most patients with the sleep disorder narcolepsy. It is presently not known why the loss of hypocretin neurons occurs in these patients. In the present study, we tested the role of inflammation in the degeneration of hypocretin neurons. The proinflam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.06.016
更新日期:2004-09-03 00:00:00
abstract::Opioid modulation of calcium currents was studied in acutely dissociated rat basal forebrain neurons using the whole cell patch-clamp recording technique. The mu-opioid receptor agonist DAGO reversibly suppressed high-voltage activated calcium currents and slowed their rate of activation, while neither delta- nor kapp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00206-0
更新日期:1997-05-30 00:00:00
abstract::Spinal nociceptive neural circuits undergo considerable changes during the postnatal period. This study showed that neonatal rats exhibited earlier upregulation and faster recovery of spinal preprodynorphin (PPD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation. These da...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.039
更新日期:2005-03-21 00:00:00
abstract::Several reports during the last three decades have indicated that biosynthesis of N-acetylaspartate (NAA) occurs primarily in the mitochondria. But a recent report by Lu et al. in this journal [2004; 122: 71-78] and subsequent two reports that cited those data suggested a predominant microsomal localization of the NAA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.06.040
更新日期:2008-08-28 00:00:00
abstract::Previous studies suggested the existence of two populations of cells in the mammalian sympathetic nervous system which differ in their ability to express phenylethanolamine N-methyltransferase (PNMT), the enzyme which specifically subserves the biosynthesis of epinephrine: (1) sympathoblasts and their progeny, the nor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90163-9
更新日期:1984-04-01 00:00:00
abstract::Nerve fibers and terminals immunoreactive for cholecystokinin (CCK) were demonstrated in the nucleus of the solitary tract (NTS) of the rat using light and electron microscopic immunocytochemistry. The following morphological and biochemical evidence suggests that CCK in the NTS seems to be of extrinsic, most probably...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90408-5
更新日期:1982-12-09 00:00:00
abstract::Sodium and potassium currents in the node of Ranvier decrease exponentially with time during long lasting voltage clamp experiments. This decline is strongly dependent on temperature (Q10 approximately 3). Thiamine and, particularly, its diand triphosphoric acid esters are shown to prevent this exponential decline of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90720-9
更新日期:1975-05-23 00:00:00
abstract::In the central nervous system (CNS) insulin mediates a variety of effects including feeding, metabolism and cognition. The cognitive enhancing effects of insulin are proposed to be mediated through activation of insulin receptors in the hippocampus, an important integration center for learning and memory in the mammal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.005
更新日期:2009-11-03 00:00:00
abstract::The electrophysiological effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK-801 (MK-801) on nigrostriatal and mesoaccumbal dopaminergic (DA) neurons were evaluated in chloral hydrate-anesthetized rats. MK-801 (0.05-3.2 mg/kg, i.v.) stimulated the firing rates of 14 (74%) of 19 nigrostriatal D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91091-r
更新日期:1992-09-11 00:00:00
abstract::The aim of this study was to determine if a prolonged period (7 or 14 days) of hypodynamia-hypokinesia (HH) affects the conduction of afferent input and the cortical and spinal responsiveness. Acute recordings of cortical and spinal somatosensory evoked potentials (SEPs) were performed after stimulation of the sciatic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02804-x
更新日期:2003-07-18 00:00:00
abstract::In in vitro slices prepared from rat sensorimotor cortex, intracellular recordings were obtained from 107 layer V pyramidal neurons, subsequently injected with biocytin for morphological reconstruction. Of the 107 neurons, 59 (55.1%) were identified as adapting (45) or non-adapting (13) regular spiking neurons (RS), a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00807-3
更新日期:1995-10-23 00:00:00
abstract::The development of spontaneous activity in response to morphine administration was studied at different postnatal ages in C57BL/6 mice. Morphine induced hyperactivity at all ages except in 3-week-old mice, in which a catatonic effect is evident. The results indicate that the neurophysiological and inhibitory systems r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(81)90029-8
更新日期:1981-11-01 00:00:00
abstract::The aim of this study was to evaluate the effects of hypothermia on bilirubin-induced alterations in brain cell membrane function and energy metabolism in the developing brain. Thirty-seven newborn piglets were divided randomly into four groups: normothermic control (NC, n=9); hypothermic control (HC, n=7); normotherm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03186-9
更新日期:2001-12-20 00:00:00
abstract::Neural correlates of conscious awareness can be comfortably studied when awareness of the target stimuli is a varying dependent variable in the experimental conditions where the key independent variables are kept invariant. We presented vernier targets backward masked by an invariant grating with invariant SOA. EEG da...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.12.085
更新日期:2009-05-19 00:00:00
abstract::Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amn...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90807-9
更新日期:1987-03-17 00:00:00
abstract::The relationship between carotid body chemoreceptor activity and flow was studied in preparations superfused in vitro. The carotid bodies were excised from pentobarbitone-anesthetized cats and superfused with modified Tyrode's solution, buffered with HEPES-NaOH to pH 7.41. The bath temperature was kept constant at 37....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90110-2
更新日期:1988-07-05 00:00:00