Abstract：
:In the central nervous system (CNS) insulin mediates a variety of effects including feeding, metabolism and cognition. The cognitive enhancing effects of insulin are proposed to be mediated through activation of insulin receptors in the hippocampus, an important integration center for learning and memory in the mammalian brain. Since less is known regarding insulin signaling events in the hippocampus, the aim of the current study was to determine whether insulin stimulates similar signaling cascades and GLUT4 translocation in the rat hippocampus as has been described in peripheral tissues. Intracerebroventricular administration of insulin increases hippocampal insulin levels and also stimulates the phosphorylation of Akt in a time-dependent manner. Insulin also stimulates the translocation of GLUT4 to hippocampal plasma membranes in a time course that mirrors the increases in glucose uptake observed during the performance of hippocampal-dependent tasks. Insulin stimulated phosphorylation of Akt and translocation of GLUT4 were blocked by pretreatment with the PI3-kinase inhibitor LY294002. Confocal immunofluorescence determined that insulin stimulated phosphorylation of Akt was localized to neurons and colocalized with the insulin receptor and GLUT4 in the rat hippocampus, thereby identifying the functional anatomical substrates of insulin signaling in the hippocampus. These results demonstrate that insulin-stimulated translocation of GLUT4 to the plasma membrane in the rat hippocampus occurs via similar mechanisms as described in peripheral tissues and suggests that insulin-mediated translocation of GLUT4 may provide a mechanism through which hippocampal neurons rapidly increase glucose utilization during increases in neuronal activity associated with hippocampal-dependent learning.
journal_name
Brain Resjournal_title
Brain researchauthors
Grillo CA,Piroli GG,Hendry RM,Reagan LPdoi
10.1016/j.brainres.2009.08.005subject
Has Abstractpub_date
2009-11-03 00:00:00pages
35-45eissn
0006-8993issn
1872-6240pii
S0006-8993(09)01630-8journal_volume
1296pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked inductio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91337-g
更新日期：1990-08-13 00:00:00
abstract：:Female golden-mantled ground squirrels that sustained complete ablation of the suprachiasmatic nucleus (SCNx) were housed pre- and post-operatively at 23 degrees C and then at 6.5 degrees C for 5-7 yr. SCNx and control animals held at the higher temperature manifested circannual rhythms (CARs) in body mass. In contras...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01263-8
更新日期：1998-01-26 00:00:00
abstract：:The aim of this investigation was to determine whether an ingredient of green tea, epigallocatechin gallate (EGCG) could attenuate oxidative stress-induced degeneration of the retina as occurs in age-related macular degeneration (AMD) and glaucoma. Initial in vitro studies on brain membranes showed that EGCG was appro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.067
更新日期：2006-12-08 00:00:00
abstract：:The structurally related Aconitum alkaloids aconitine, lappaconitine, and 6-benzoylheteratisine inhibited the orthodromic and antidromic population spike in hippocampal CA1 area in a frequency-dependent manner. Aconitine (1 microM) completely suppressed epileptiform activity induced by omission of Mg2+ as well as norm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00990-0
更新日期：1996-10-28 00:00:00
abstract：:Patches of transnueronal degeneration were produced in the lateral geniculate nucleus (LGN) by retinal laser burns and a tarsorrhaphy was performed in the contralateral eye of Macaca mulatta during infancy. The adverse effect of unilateral visual deprivation on geniculate cell growth was absent in those portions of de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90772-1
更新日期：1976-07-30 00:00:00
abstract：:Following infection with influenza virus, animals display decreased locomotor activity and feeding behavior and loss of body weight. It has been suggested that these effects may be mediated by cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), induced by the infe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01009-3
更新日期：1997-11-21 00:00:00
abstract：:The disturbance of microcirculation following cerebral ischemia leads to an enlargement of cerebral infarct volume. Endogenous thrombin may play a role in this disturbance of microcirculation following cerebral ischemia. Therefore, the inhibition of thrombin may improve neurodegeneration and the accumulation of cerebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02354-x
更新日期：2001-06-01 00:00:00
abstract：:The malformative cortical lesions in the cerebral cortex that are characteristic of focal cortical dysplasia type IIb (FCDIIb) and tuberous sclerosis complex (TSC) are well-recognized causes of chronic intractable epilepsy in children. Increasing evidence suggests that extracellular matrix molecules play important rol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.03.009
更新日期：2012-05-09 00:00:00
abstract：:Cyclic AMP is a second messenger by which different extracellular signals are transduced into biological responses. Within the cell, most of the effects of cAMP are mediated through the cAMP protein kinase which appears to be localized in specific compartments of the cell near to their substrate proteins. In the prese...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90244-h
更新日期：1993-01-29 00:00:00
abstract：:We investigated the projection from the infralimbic division of the prefrontal cortex (area 25) to histaminergic neurons in the posterior hypothalamic area. Phaseolus vulgaris-leucoagglutinin (PHA-L) was injected in the prefrontal cortex of rats. Frozen brain sections were subjected to combined PHA-L and histidine dec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90802-x
更新日期：1987-03-17 00:00:00
abstract：:The administration of alpha 2-adrenoreceptor antagonists SKF 64139 or SKF 72223 (TIQ derivatives) elicits an increase in striatal DOPA synthesis. The findings that the enhanced DOPA synthesis is reversed by pretreatment of the animals with clonidine or with the D beta H inhibitor FLA-63 suggest that action of the TIQ ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90427-3
更新日期：1981-12-28 00:00:00
abstract：:Past research investigating the rostral ventromedial medulla (RVM) in anesthetized animals has found two distinct classes of cells, ON and OFF, noted for their distinct responses to noxious stimuli and to morphine. However, only one class (ON) has been found in the awake animal paradigm. We report in this paper that w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90385-z
更新日期：1993-02-26 00:00:00
abstract：UNLABELLED:Although corticotropin-releasing factor (CRF) receptors have been identified throughout the brain, relatively little is known about the regulation of CRF receptors. Recent investigations aimed at developing an in vitro model for studying the regulation of CRF receptors demonstrated CRF binding in brain cell ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90357-5
更新日期：1988-07-19 00:00:00
abstract：:The activity of single dopaminergic (DA) neurons (total n = 77) in the midbrain of awake, unrestrained rats was examined. The firing rates and patterns of ventral tegmental area (A10) cells (n = 39) were similar to those of identified DA neurons in anesthetized and paralyzed rats. Unit activity was briefly stimulated ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90988-7
更新日期：1987-03-03 00:00:00
abstract：:Two-day-old rats were pretreated with 50 mg/kg of capsaicin. After 3--4 months, specific binding of [3H]muscimol and [3H]strychnine was measured in membrane preparations from dorsal spinal cord. A 20-30% decrease of the number of [3H]muscimol binding sites was observed after capsaicin treatment. In contrast, [3H]stryc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90160-2
更新日期：1980-12-08 00:00:00
abstract：:Newborn rats were given saline or cholecystokinin8 (CCK8) (5 micrograms/kg, twice daily) i.p. for 3 weeks. On day 21, effects on brain development were assessed. CCK-like immunoreactivity was measured in 7 brain regions; a small (12-18%) but significant decrease in endogenous levels of this peptide was detected in cer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90147-7
更新日期：1987-03-01 00:00:00
abstract：:We suggested previously that increases in the extracellular [Ca2+] or [Mg2+] lengthen miniature end-plate currents (m.e.p.c.s.) because the divalent cations decrease the negative surface potential on the end-plate, and thereby increase the voltage drop within the membrane. The increased voltage drop would lengthen the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91065-4
更新日期：1982-06-10 00:00:00
abstract：:Rarely do we encounter a single odorant in our environment. Perception of odours, therefore, usually depends on the reception and neural processing of many components. However, little is known about how and where odour mixtures are processed. Evidence is presented here that suppression of one odour by another, a commo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90419-7
更新日期：1987-11-17 00:00:00
abstract：:Activation of phospholipase C (PLC) coupled to phosphoinositide (PtdIns) hydrolysis occurs through one of the two pathways. One of the major pathways for the neurotransmitter signaling involves phosphoinositide (PtdIns) specific and G-protein dependent PLC-beta, which stimulates the formation of inositol triphosphate ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01272-9
更新日期：1996-02-05 00:00:00
abstract：:The nonsteroidal anti-inflammatory drugs are presumed to produce their analgesic effects by inhibiting the cyclooxygenase catalyzed metabolism of arachidonic acid to hyperalgesic prostanoids. This study examined the hyperalgesic effect of a range of prostaglandins. We found, employing the rat paw-withdrawal test, that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90389-s
更新日期：1990-12-24 00:00:00
abstract：:Recently, this laboratory provided evidence that interleukin-1beta (IL-1beta), an immune and brain-derived cytokine, microinjected into the medial hypothalamus, potentiates defensive rage behavior in the cat elicited from the midbrain periaqueductal gray (PAG), and that such effects are blocked by a 5-HT2 receptor ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.04.086
更新日期：2005-06-28 00:00:00
abstract：:The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02659-2
更新日期：2001-08-10 00:00:00
abstract：:Brain oscillations provide a rich source of potentially useful endophenotypes (intermediate phenotypes) for psychiatric genetics, as they represent important correlates of human information processing and are associated with fundamental processes from perception to cognition. These oscillations are highly heritable, a...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2008.06.053
更新日期：2008-10-15 00:00:00
abstract：:The pontine respiratory neurons (PRG) in the 'pneumotaxic centre' have been hypothesized to contribute to phase-switching of neural respiratory activity, especially in terminating inspiration. To define the neural elements involved in phase-switching, we recorded respiratory neurons extra- and intracellularly in anest...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91025-1
更新日期：1994-02-14 00:00:00
abstract：:This study examines the role of catecholamines, cell bodies and fibers of passage within the subcoeruleus area (subLC) in the arginine vasopressin (AVP) response to splanchnic osmotic stimulation and hemorrhage. Bilateral chemical lesions were induced into the subLC, approximately 1 mm ventral to the locus coeruleus (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90929-4
更新日期：1992-05-15 00:00:00
abstract：:In freely-moving female rats the effects of intraventricular infusion of norepinephrine (NE) on multiunit activity (MUA) were examined in the Diagonal Band of Broca (DBB), medial preoptic area (MPOA) and anterior hypothalamic area (AHA), regions containing neurons producing luteinizing hormone-releasing hormone (LHRH)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91089-1
更新日期：1981-12-07 00:00:00
abstract：:The default mode network (DMN) is characterised by coherent very low frequency (VLF) neural oscillations in the resting brain. The attenuation of this activity has been demonstrated following the transition from rest to performance of a broad range of cognitive goal-directed tasks. Whether the activity of resting stat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.05.043
更新日期：2013-08-02 00:00:00
abstract：:Toxoplasma gondii can cause parasitic encephalitis, a life-threatening infection that predominately occurs in immunocompromised individuals. T. gondii has the ability to invade the brain, but the mechanisms by which this parasite crosses the blood-brain-barrier (BBB) remain incompletely understood. The present study r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147002
更新日期：2020-11-01 00:00:00
abstract：:The activity of cerebellar Purkinje cells during controlled and passive movement of the forepaw was studied in the cat. Burst responses characteristic of activation by climbing fibers were observed in Purkinje cells in lobules Vb and Vc of the cerebellar vermis and paravermis. The climbing fiber responses followed the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90069-x
更新日期：1976-04-16 00:00:00
abstract：:Neuromuscular patterns associated with the development of hindlimb stepping behaviors were studied from birth to postnatal day 60 in normal kittens. Hindlimb muscles were chronically implanted with EMG electrodes at birth to characterize interlimb coordination and intralimb synergies during development of overground a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90084-3
更新日期：1988-01-01 00:00:00
