Inhibition of neuronal activity in rat hippocampal slices by Aconitum alkaloids.

abstract：:Dopamine-releasing protein (DARP) is a novel factor involved in the function and development of catecholaminergic systems. To test whether a peptide synthesized from the N-terminus of DARP (DARP-36aa) ameliorates deficits in nigrostriatal dopamine, rats were unilaterally lesioned with MPP+, 1 day before administration...

journal_title：Brain research

authors： Phelps SM,Ramirez VD

更新日期：1994-12-12 00:00:00

abstract：:Anorexia nervosa is associated with vasopressin, oxytocin and serotonin abnormalities. Because of the relationship between exercise and anorexia nervosa, we explored the weight-loss syndrome produced by wheel running in food-deprived rats. Its effects on regional vasopressin and oxytocin concentrations were determined...

journal_title：Brain research

authors： Aravich PF,Rieg TS,Ahmed I,Lauterio TJ

更新日期：1993-05-28 00:00:00

abstract：OBJECTIVE:There is an increasing interest concerning the contribution of astrocytes to the intrinsic bioremediation of ischemic brain injury. The aim of this work was to disclose the effects and mechanism of dexmedetomidine (DEX) on the apoptosis of astrocytes under oxygen glucose deprivation (OGD) condition. METHODS:...

journal_title：Brain research

authors： Feng P,Zhang A,Su M,Cai H,Wang X,Zhang Y

更新日期：2021-01-01 00:00:00

abstract：:The purpose of this study was to compare the relative effects of mannitol and hypertonic saline (HTS) on calpain activity, apoptosis and neuroinflammatory response induced by experimental cortical contusion. Four groups of 5 Sprague-Dawley male rats were submitted to focal brain injury produced by exposing the parieta...

journal_title：Brain research

authors： Soustiel JF,Vlodavsky E,Zaaroor M

更新日期：2006-07-26 00:00:00

abstract：:The electroretinogram (ERG) of the dark-adapted goldfish was examined before and after intravitreal injection of DL-2-amino-4-phosphonobutyric acid (APB). APB abolished the b-wave and decreased absolute sensitivity of the remaining waveform, which was composed of a vitreal-negative component followed by a vitreal-posi...

journal_title：Brain research

authors： DeMarco PJ Jr,Powers MK

更新日期：1989-03-20 00:00:00

abstract：:Because considerable work has implicated the basal ganglia in oral-ingestive behavior, an assessment was made of the effects of trigeminal stimuli upon entopeduncular single units. Units wre recorded extracellularly in awake, paralyzed and locally anesthetized cats. The effects of two types of sensory input were teste...

journal_title：Brain research

authors： Lidsky TI,Robinson JH,Denaro FJ,Weinhold PM

更新日期：1978-02-10 00:00:00

abstract：:The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...

journal_title：Brain research

authors： Leclerc R,Pelletier G

更新日期：1977-07-01 00:00:00

abstract：:The distribution of antidiabetic sulfonylurea [( 3H]glibenclamide) binding sites is heterogeneous in rat brain. Pyramidal and extrapyramidal motor system contain the highest densities of sites, particularly in the substantia nigra and in the globus pallidus. Only low levels are present in the hypothalamic nuclei and t...

journal_title：Brain research

authors： Mourre C,Ben Ari Y,Bernardi H,Fosset M,Lazdunski M

更新日期：1989-05-01 00:00:00

abstract：:The accumulation of acid-labile CO2 was measured in the rat brain at early times after exposure to 30% CO2 in oxygen. In particular, the effect on CO2 accumulation of inhibiting brain carbonic anhydrase with acetazolamide was studied. For 57 rats, a rat head perfusion technique was used which permits control and rapid...

journal_title：Brain research

authors： Thompson AM,Thompson JL,Robertson RC

更新日期：1980-09-15 00:00:00

abstract：:A daily variation of tryptophan hydroxylase (TrH) activity was observed in the raphe dorsalis (RD), raphe centralis (RC) and striatum (St) of 3 inbred strains of mice (BALB/c, C57BL/6, C57BR) and of the reciprocal hybrids obtained from Balb/c and C57BL6. Significant differences of the characteristics of these rhythms ...

journal_title：Brain research

authors： Natali JP,McRae-Degueurce A,Chouvet G,Pujol JF

更新日期：1980-06-02 00:00:00

abstract：:We measured the effect of high PCO (500-550 Torr) on the pHi and [Ca2+]i in cultured glomus cells of adult rat carotid body (CB) as a test of the two models currently proposed for the mechanism of CB chemoreception. The metabolic model postulates that the rise in glomus cell [Ca2+]i, the initiating reaction in the sig...

journal_title：Brain research

authors： Mokashi A,Roy A,Rozanov C,Osanai S,Storey BT,Lahiri S

更新日期：1998-08-24 00:00:00

abstract：:To test the hypothesis that stimulation of glial peroxidase activity by estrogens may play a role in the pathogenesis of the previously reported degenerative changes in the hypothalamic arcuate nucleus that occur in female rats treated with a long-acting estrogen preparation, the cellular localization and number of pe...

journal_title：Brain research

authors： Schipper HM,Lechan RM,Reichlin S

更新日期：1990-01-22 00:00:00

abstract：:Embryonic cortex from 19-day fetuses was transplanted in a medial frontal cortex wound cavity of 105-day-old male rats. Nissl-stained tissue revealed little internal laminar organization. Graft sections impregnated by the Loyez method exhibited bands of myelinated fibers surrounding implants as well as long-interconne...

journal_title：Brain research

authors： Mufson EJ,Labbe R,Stein DG

更新日期：1987-01-13 00:00:00

abstract：:We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was de...

journal_title：Brain research

authors： Noh HS,Kim DW,Kang SS,Cho GJ,Choi WS

更新日期：2005-04-25 00:00:00

abstract：:The rapidly evolving science of epigenetics is transforming our understanding of the nervous system in health and disease and holds great promise for the development of novel diagnostic and therapeutic approaches targeting neurological diseases. Increasing evidence suggests that epigenetic factors and mechanisms serve...

journal_title：Brain research

authors： Qureshi IA,Mehler MF

更新日期：2015-12-02 00:00:00

abstract：:The effects of prostaglandin E1 (PGE1) on porcine cerebral arteries were studied in the absence and presence of cyclooxygenase inhibitors, 5 x 10(-6) M indomethacin or 10(-4) M aspirin. In preparations placed at a resting tension, 3 x 10(-9) to 10(-6) M PGE1 caused dose-dependent contractions. In prostaglandin F2 alph...

journal_title：Brain research

authors： Fukuda S,Taga K,Tsukui A,Nishimura N,Kumagai Y,Shimoji K

更新日期：1989-09-04 00:00:00

abstract：:Repeated amphetamine administration produced behavioral sensitization to subsequent amphetamine challenge. The development of sensitization was blocked by coadministration of the N-methyl-D-aspartate (NMDA) antagonist MK-801. Conditioned locomotion, as revealed by saline challenge, was also blocked by MK-801, suggesti...

journal_title：Brain research

authors： Wolf ME,Khansa MR

更新日期：1991-10-18 00:00:00

abstract：:The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) an...

journal_title：Brain research

authors： Yamuy J,Engelhardt JK,Morales FR,Chase MH

更新日期：1992-01-20 00:00:00

abstract：:Enriched environment (EE) has been shown to have beneficial effects on cognitive recovery after brain injury. Typical EE comprises three components: (i) enlarged living area providing physical activation, (ii) sensory stimulation, and (iii) social stimulation. The present study assessed the specific contribution of th...

journal_title：Brain research

authors： Gajhede Gram M,Gade L,Wogensen E,Mogensen J,Malá H

更新日期：2015-12-10 00:00:00

abstract：:The purpose of this work was to characterize the gap junctions between cultured glomus cells of the rat carotid body and to assess the effects of acidity and accompanying changes in [Ca(2+)](i) on electric coupling. Dual voltage clamping of coupled glomus cells showed a mean macrojunctional conductance (G(j)) of 1.16 ...

journal_title：Brain research

authors： Abudara V,Jiang RG,Eyzaguirre C

更新日期：2001-10-19 00:00:00

abstract：:Diffusion patterns of 14C-labeled penicillin, resulting from microinjections into different neocortical laminae, were compared with simultaneous electrophysiologic monitoring of epileptogenesis across these laminae. Injections into layer IV produced response alterations quickly in all recorded layers even with penicil...

journal_title：Brain research

authors： Chatt AB,Ebersole JS

更新日期：1984-01-09 00:00:00

abstract：:A diffusion model is described here, which allows for the estimations of drug concentration changes in porous media, such as in slice tissues of the central nervous system (CNS) bathed in unstirred solutions following abrupt changes of drug concentration. This model may be used for the interpretation of data obtained ...

journal_title：Brain research

authors： Lipinski HG,Bingmann D

更新日期：1987-12-22 00:00:00

abstract：:Dysfunction in the hypothalamic GABAergic system has been implicated in panic syndrome in humans. Furthermore, several studies have implicated the hypothalamus in the elaboration of pain modulation. Panic-prone states are able to be experimentally induced in laboratory animals to study this phenomenon. The aim of the ...

journal_title：Brain research

authors： Freitas RL,Uribe-Mariño A,Castiblanco-Urbina MA,Elias-Filho DH,Coimbra NC

更新日期：2009-12-11 00:00:00

abstract：:By using enkephalin immunohistochemistry combined with retrograde fluorescent labelling, a great majority of neurons in the rat cerebellum sending their axons to the spinal cord were shown to contain enkephalin immunoreactivity. These neurons were numerous and clustered in the fastigial nucleus but far less abundant i...

journal_title：Brain research

authors： Ikeda M,Houtani T,Nakagawa H,Baba K,Kondoh A,Ueyama T,Yamamoto T,Gemba H,Sugimoto T

更新日期：1995-09-04 00:00:00

abstract：:The role of the cerebellum and the red nucleus in the conditioned eyeblink response was assessed, using a combination of reversible lesions and multiple-unit extracellular recording in the awake, behaving rabbit. Lesion, recording, and stimulation experiments have indicated that both of these structures are involved i...

journal_title：Brain research

authors： Chapman PF,Steinmetz JE,Sears LL,Thompson RF

更新日期：1990-12-24 00:00:00

abstract：:The binding of the selective alpha 2-adrenoceptor antagonist radioligand [3H]rauwolscine ([3H]RAUW) to homogenates of cat frontal cerebral cortex and cat lumbar spinal cord was investigated. Experiments were performed at 20 degrees C in 50 mM Tris HCl/l mM Na2EDTA buffer (pH 6.9 at 20 degrees C). At this temperature, ...

journal_title：Brain research

authors： Howe JR,Yaksh TL

更新日期：1986-03-12 00:00:00

abstract：:Synaptic activation of the neurosecretory cells within the glandular lobe of the corpus cardiacum of locusts results in the release of bioassayable adipokinetic hormones and an elevation in cAMP. The effectiveness of several putative aminergic neurotransmitters in mimicking these actions of the natural transmitter, an...

journal_title：Brain research

authors： Orchard I,Gole JW,Downer RG

更新日期：1983-12-12 00:00:00

abstract：:Rats were anesthetized with a continuous infusion of pentobarbital. First we showed that electroacupuncture (EA) suppressed the tail flick nociceptive reflex. Naltrexone (a long acting opiate antagonist) was given either intravenously or intrathecally to attempt to block this EA effect. The naltrexone prevented this E...

journal_title：Brain research

authors： Pomeranz B,Bibic L

更新日期：1988-06-14 00:00:00

abstract：:Despite the significant advances that have been made in understanding the pathophysiology of cerebral ischemia on the cellular and molecular level, only one drug, the thrombolytic tissue plasminogen activator (rt-PA), is approved by the FDA for use in patients with acute ischemic stroke. Therefore, there is a critical...

journal_title：Brain research

authors： Maher P,Salgado KF,Zivin JA,Lapchak PA

更新日期：2007-10-10 00:00:00

abstract：:This study investigated the relationship between central cholinergic neurons and insulin secretion in bilateral adrenalectomized fed rats. Neostigmine (a cholinesterase inhibitor, 5 x 10(-8) mol) administered into the third cerebral ventricle produced significant increases in hepatic venous plasma insulin and glucose ...

journal_title：Brain research

authors： Gotoh M,Iguchi A,Yatomi A,Uemura K,Miura H,Futenma A,Kato K,Sakamoto N

更新日期：1989-07-24 00:00:00