Abstract：
:The objective of this study was to determine whether the aging process influences the changes in the electrophysiological properties of motoneurons that occur as a consequence of axotomy. Accordingly, using intracellular recording and stimulating techniques, the basic electrical properties of control (unaxotomized) and axotomized spinal cord motoneurons of aged cats were determined. Compared with control motoneurons, axotomized motoneurons exhibited increases in input resistance (Rin), membrane time constant (tau b) and the equalizing time constant (tau c). While the electrotonic length (L) remained unchanged, axotomy induced a decrease in the total cell capacitance (Ccell). The post-axotomy reduction of Ccell indicates that the motoneuron surface area was reduced and the increased membrane time constant indicates that there was an increase in membrane resistivity (Rm). The post-axotomy conservation of L accompanied by an increase in Rm suggests that aged axotomized motoneurons undergo geometrical changes. Furthermore, calculations based on cable theory suggest that the diameter of the equivalent cylinder (d) decreased following axotomy, whereas the equivalent cylinder length (l) remained unaffected. It is concluded that axotomy produces significant alterations in the soma-dendritic portion of aged spinal motoneurons, as indicated by the changes found in their passive electrophysiological properties, and that the pattern of the response that occurs in axotomized motoneurons of adult cats is also present in axotomized motoneurons of aged animals.
journal_name
Brain Resjournal_title
Brain researchauthors
Yamuy J,Engelhardt JK,Morales FR,Chase MHdoi
10.1016/0006-8993(92)90594-ysubject
Has Abstractpub_date
1992-01-20 00:00:00pages
300-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90594-Yjournal_volume
570pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The medial nucleus of the amygdala, bed nucleus of the stria terminalis, and medial preoptic area appear to mediate steroidal regulation of mating behavior in male rodents. The mechanism of action has not been determined. One way testosterone could enhance neuronal function is by increasing neurotransmitter levels, th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91077-r
更新日期：1992-09-11 00:00:00
abstract：:Several studies have demonstrated in the past that endogenous opioid peptides and opioid receptors may be involved as mediators of brain tissue growth and function in the neonate. Applying histological and autoradiographic methods, we have examined the effect of the mu-receptor-specific antagonist, naltrexone, on the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90515-5
更新日期：1989-05-08 00:00:00
abstract：:Binge-like ethanol treatment of septal neurons blunts GABAAR-mediated miniature postsynaptic currents (mPSCs), suggesting it arrests synaptic development. Ethanol may disrupt postsynaptic maturation by blunting feedback signaling through immature GABAARs. Here, the impact of ethanol on the sensitivity of mPSCs to zolp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.023
更新日期：2006-05-17 00:00:00
abstract：:To assess the role of calcitonin gene-related peptide (CGRP) within the trigeminal subnucleus caudalis (Vc) on adrenal and autonomic function, microinjections were directed at different laminae of Vc in chloralose-anesthetized cats. Microinjections of CGRP (5 pmol, 100 nl) into laminae I-II increased significantly the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90713-6
更新日期：1991-08-30 00:00:00
abstract：:In this study, the effects of chronic morphine administration (20-30 days) on long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices. Orthodromic population spike (OPS) amplitude and delay (peak latency) were measured as indices of increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01148-2
更新日期：1999-01-09 00:00:00
abstract：:30-Day-old male Wistar rats were tested for acquisition and retention of operant conditioned behavior after bilateral subicular lesions made either electrolytically or chemically (ibotenic acid). The acquisition of operant learning was carried out in lesioned rats by assessing the number of sessions required to learn ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01135-3
更新日期：1997-01-16 00:00:00
abstract：:Inflammation probably plays a significant role in perinatal brain injury. To study the contribution of locally produced cytokines, the effect on cell death of addition of IL-8 and MCP-1 or antibodies to these, and the impact of acidosis, human postmitotic NT2-N neurons were exposed to 3 h of hypoxia and glucose depriv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.051
更新日期：2006-10-03 00:00:00
abstract：:Polyamines play critical roles during the development of brain neurons. In the present study we examined the effects of polyamines on neuronal apoptotic death. Rat cerebellar granule neurons were cultured in the presence of a depolarizing concentration of KCl (25 mM) in the medium. Apoptotic neuronal death was induced...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00011-5
更新日期：1997-04-11 00:00:00
abstract：:The roles of noradrenergic and serotonergic projections to the hippocampus were investigated with respect to their involvement in the intracranial self-stimulation of this structure. In the first study, 6-hydroxydopamine-induced lesions of the dorsal tegmental noradrenergic bundle, which depleted hippocampal NE by 97%...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90136-6
更新日期：1977-11-04 00:00:00
abstract：:Stereotaxic microinjections of the excitotoxin, ibotenic acid, were made into the striatum, hippocampus or cerebellum of the immature (7-day-old) rat. Two days later, pups were decapitated and the brains processed for light microscopic examination or neurochemical analyses. 10 micrograms ibotenate caused a complete lo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90467-0
更新日期：1984-07-30 00:00:00
abstract：:The effects of 17 beta-estradiol benzoate (EB), ethynodioldiacetate and ovine prolactin on dopamine (DA) turnover have been studied. As an index for a change in turnover, differences in DA depletion following tyrosine hydroxylase inhibition with alpha-methyl-tyrosine methylester were observed. DA was measured by means...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90728-x
更新日期：1978-06-16 00:00:00
abstract：:Previous studies showed that hyperbaric oxygen (HBO) promoted cell proliferation in hypoxic-ischemic (HI) neonate rats. Neural stem cells (NSC) existed in the brain lifelong and can be activated. This study was undertaken to assess whether HBO treatment promoted the proliferation of NSC and repaired the brain damage r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.016
更新日期：2008-07-30 00:00:00
abstract：:The purpose of this study was to identify the functional fields activated in relation to the NO-GO decision. Nine healthy subjects participated in the study which consisted of two test positron emission tomography (PET) scans (GO/NO-GO task and response selection task) and one control scan. In the response selection t...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-07-22 00:00:00
abstract：:Electrical stimulation in the dorsal acoustic stria (DAS) and the posterior and dorsal part of the ventral cochlear nucleus (VCN) was used to identify the response properties of efferent axons from the dorsal cochlear nucleus (DCN) in unanesthetized, decerebrate cats. Responses recorded in the DCN of this preparation ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91091-4
更新日期：1980-10-27 00:00:00
abstract：:Leumorphin, an opioid peptide whose functions are unknown, is found in mammalian brain and pituitary and stimulates lordosis behavior in estrogen-treated female rats. To elucidate the role of leumorphin in the physiological control of female sexual behavior, the levels of immunoreactive (ir) leumorphin as well as ir d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90417-8
更新日期：1986-05-28 00:00:00
abstract：:It is well known that the nerve growth factor (NGF) may serve as a link between inflammation and hyperalgesia. Recent experiments showed that systemic injection of NGF dramatically stimulated the expression of brain-derived neurotrophic factor (BDNF) mRNA in the dorsal root ganglion (DRG). In the present study, we eva...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/S0006-8993(97)00048-6
更新日期：1997-02-28 00:00:00
abstract：:In rats kainic acid-induced seizures were accompanied by time-dependent cerebral cysteinyl-leukotriene (LT) and prostaglandin (PG) F2 alpha formation. Cysteinyl-LT were identified in the rat brain tissue extracts by their immunoreactive properties and their retention times upon reversed phase HPLC profiling. In perfus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90579-z
更新日期：1990-05-07 00:00:00
abstract：:It is known that transmitter release depends upon the entry of calcium ions into the synaptic terminal. Mitochondria have been suggested to play a key role on the regulation of intracellular Ca2+ concentration, thereby influencing transmitter liberation and synaptic transmission. Here we report the stimulatory effect ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90618-6
更新日期：1980-01-13 00:00:00
abstract：:Stimulation of cardiac sympathetic afferents evokes excitatory cardiovascular reflexes. However, the exact regions in the brain that integrate these reflexes have not been identified. Expression of c-Fos in the neurons provides a useful marker of the activated neurons. In the present study, we examined the response of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03259-0
更新日期：2002-01-18 00:00:00
abstract：:The mismatch negativity (MMN) event-related potential is elicited by changes in repetitive auditory stimuli. The present paper suggests that: (1) an acoustic model of the auditory environment is maintained even in the absence of attention focussed on auditory stimuli, preattentively detecting repetitive features of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01008-6
更新日期：1996-12-02 00:00:00
abstract：:The developmental control of neuroblast proliferation is absolutely required for the assembly and function of the central nervous system. A lethal mutation in trol results in the failure of quiescent neuroblasts to begin division at the appropriate time. I have established a culture system in which quiescent neuroblas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01292-x
更新日期：1999-02-06 00:00:00
abstract：:Growth factor-dependent proliferation of neuronal progenitors is an essential stage in CNS development. Although several of these growth factors have been identified, high levels of neuregulin 1 (NRG1) mRNA and protein expression in the CNS during the time of neuronal progenitor expansion suggest NRG1 growth factors m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.06.025
更新日期：2006-09-07 00:00:00
abstract：:Neurotensin (NT) is an endogenous brain tridecapeptide for which high affinity binding sites exist in the central nervous system. We have investigated the effects of NT incubation with rat neostriatal slices on calcium/calmodulin (Ca/CaM)-dependent protein phosphorylation. Slices were incubated with NT (5 or 50 nM) fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91311-n
更新日期：1991-04-05 00:00:00
abstract：:The effects of subchronic administration of the antidepressant fluoxetine (15 mg/kg i.p., 14 days) on thyroid hormone metabolism were investigated in 11 regions of the CNS and three peripheral tissues in the rat. Fluoxetine significantly enhanced the activity of the 5'II-deiodinase isoenzyme (5'D-II), which catalyzes ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91424-9
更新日期：1994-01-28 00:00:00
abstract：:We have examined the afferent and efferent projections between the claustrum and visual cortex in the Long-Evans rat using anterograde and retrograde axonal transport techniques. Injections of either wheat germ agglutinin/horseradish peroxidase (WGA/HRP) or Fast Blue were made into each of the main visual regions (17,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90524-4
更新日期：1985-03-11 00:00:00
abstract：:This report describes the relationship between monoamines, sleep and seizures before and 1-month after amygdala kindling in young cats (<1 year old; n=8; six female and two male). Concentrations (fmoles of norepinephrine or NE, dopamine or DA and serotonin or 5-HT) were quantified in consecutive, 5-min microdialysis s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03265-0
更新日期：2001-02-16 00:00:00
abstract：:N-Acetylated-alpha-linked acidic dipeptidase (NAALADase) hydrolyzes N-acetyl-aspartyl-glutamate (NAAG) to liberate N-acetyl-aspartate and glutamate. NAAG is a putative neurotransmitter and acts as a mixed agonist/antagonist on N-methyl-D-aspartate (NMDA) receptors and acts as an agonist on the metabotropic glutamate r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02650-6
更新日期：2001-08-03 00:00:00
abstract：:The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147069
更新日期：2020-12-01 00:00:00
abstract：:We have previously shown that the HSV-2 anti-apoptotic protein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic acid (KA)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. The present studies used DeltaRR and the ICP1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.078
更新日期：2006-11-13 00:00:00
abstract：:The possibility that gamma-aminobutyric acid (GABA) could modulate sympathetic neurotransmission in the cerebrovascular bed of the goat has been investigated by means of 3 experimental approaches: measurement of cerebral blood flow in the anesthetized animal, recording of isometric tension in isolated cerebral arterie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90887-1
更新日期：1989-07-17 00:00:00
