Abstract:
:In this study, the effects of chronic morphine administration (20-30 days) on long-term potentiation (LTP) were investigated at the Schaffer collateral-CA1 pyramidal cell synapses of the rat hippocampal slices. Orthodromic population spike (OPS) amplitude and delay (peak latency) were measured as indices of increase in synaptic efficacy. The amounts of LTP of OPS delay and LTP of OPS amplitude were higher in slices from dependent rats. Perfusion of slices from control and dependent rats with morphine containing ACSF and delivering tetanic stimulation, showed that short-term presence of morphine could not mimic the LTP enhancing effects of chronic morphine administration, however, attenuated the amount of LTP of OPS amplitude in slices of dependent rats. This study supports the hypothesis that the susceptibility of CA1 synapses to plastic changes increases by chronic, not acute exposure to morphine and suggests that a withdrawal phenomenon might be an underlying mechanism for the observed augmented LTP of OPS amplitude in slices of dependent rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Mansouri FA,Motamedi F,Fathollahi Ydoi
10.1016/s0006-8993(98)01148-2subject
Has Abstractpub_date
1999-01-09 00:00:00pages
419-23issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01148-2journal_volume
815pub_type
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