Abstract：
:The dtsz mutant hamster represents a model of primary paroxysmal dystonia, in which dystonic episodes occur in response to stress. Previous examinations demonstrated striatal dysfunctions in dtsz hamsters. In the present study, in situ hybridization was used to examine preproenkephalin and prodynorphin expression as potential indices of imbalances between the striatopallidal and striatonigral pathways. Brain analyses were performed in dtsz hamsters under basal conditions, i.e., in the absence of dystonia, as well as mutant hamsters that exhibited severe stress-induced dystonic attacks immediately prior to sacrifice. In the striatum the basal expression of prodynorphin tended to be higher, while that of preproenkephalin tended to be lower in mutant hamsters in comparison to non-dystonic control hamsters. Significant basal changes were restricted to higher levels of prodynorphin in the ventrolateral striatum and lower prodynorphin and preproenkephalin mRNA expression in the hippocampus and/or in subregions of the hypothalamus. After stressful stimulation, the neuropeptides increased in several regions in both animals groups. In comparison to stimulated control hamsters, a significantly lower prodynorphin expression was found in several limbic areas of stimulated mutant hamsters during the manifestation of dystonia, while preproenkephalin mRNA was significantly lower in the anterior and dorsal striatal subregions and in nucleus accumbens. Since changes in the expression of these opioid peptides have been suggested to be related to abnormal dopaminergic activity, the present findings may reflect disturbances in striatal dopaminergic systems, and also in limbic structures in the dtsz mutant, particularly during the expression of dystonia.
journal_name
Brain Resjournal_title
Brain researchauthors
Nobrega JN,Parkes JH,Wong P,Raymond R,Richter Adoi
10.1016/j.brainres.2004.04.046subject
Has Abstractpub_date
2004-07-23 00:00:00pages
87-95issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899304006572journal_volume
1015pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:We investigated the effects of neonatal optic nerve transection on cortical acetylcholinesterase (AChE) activity in hooded rats during postnatal development and following behavioral manipulation after weaning. AChE reaction product was quantified on digitized images of histochemically stained sections in layer IV of p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.12.080
更新日期：2007-03-30 00:00:00
abstract：:Intracerebroventricular (ICV) infusions of 2-deoxy-D-glucose (2-DG) elicited hyperglycemia and increased feeding at short latencies. If access to food was prevented for 6 h post-2-DG infusion, when blood glucose levels were normal and brain 2-DG concentrations were virtually zero, the rats still ate significantly more...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1980-11-24 00:00:00
abstract：:We have established a cell line (TB) from a cerebrospinal fluid (CSF) specimen of a patient with a primary leptomeningeal melanomatosis. TB cell line was immunoreactive with the antibodies for low molecular weight neurofilament protein, vimentin, neuron-specific enolase, chromogranin, synaptophysin and HMB-45 (an anti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01197-x
更新日期：1999-05-08 00:00:00
abstract：:The retinotopic organization of the expanded projection to the ipsilateral colliculus was studied electrophysiologically in 12 adult albino rats with one eye removed at birth. For comparison, the contralateral projection was rather variable in the representation of the nasotemporal axis of the retina along the rostroc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90200-2
更新日期：1984-11-12 00:00:00
abstract：:In recent years estradiol has emerged as a potential regulator of transient receptor potential vanilloid (TRPV) cationic channels in the peripheral tissues and sensory neurons, however, its analogous role in the CNS is poorly understood. TRPV channels modulate Ca2+ signalling, neurotransmission and behaviour, and expr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.09.005
更新日期：2018-12-15 00:00:00
abstract：:Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate. Axotomized neurons in the periphery can spontaneously m...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2020.146864
更新日期：2020-08-01 00:00:00
abstract：:The mechanisms responsible for the rate of rise (RR) of cumulative depolarization induced by dorsal root stimulus trains were investigated with intracellular recordings from motoneurones of the rat isolated spinal cord. The NMDA receptor antagonists CPP or APV depressed the cumulative depolarization but not its RR whi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00997-3
更新日期：1996-11-04 00:00:00
abstract：:Morphologic and metabolic aspects of androgen effects on the developing spinal cord were studied in organotypic cultures of the E13 (embryonic day 13) fetal mouse lumbosacral spinal cord, maintained as either hemisected, homologous explant pairs co-cultured with bulbocavernosus muscle (morphologic studies), or as whol...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90769-4
更新日期：1987-03-17 00:00:00
abstract：:Immunohistochemical and retrograde tracing techniques were combined to demonstrate the occurrence of displaced ganglion cells (DGCs) exhibiting substance P-like immunoreactivity (SP-LI) in the pigeon retina. Following injections of rhodamine-labeled latex microspheres into the nucleus of the basal optic root (accessor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91159-x
更新日期：1991-04-12 00:00:00
abstract：:The colocalisation of neuropeptide Y (NPY)- and 5-hydroxytryptamine (5-HT)-immunoreactivities in intracardiac neurones in dissociated cultures from the atria and interatrial septum of newborn guinea pig heart was demonstrated by the sequential application of specific antisera which were visualised by two different flu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90541-5
更新日期：1987-09-29 00:00:00
abstract：:The short term effects of spinal cord hemisection on protein synthesis in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of spinal cord. Animals were sacrificed 3, 6, or 13 days after hemisection. Two normal animals an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)91046-5
更新日期：1976-07-23 00:00:00
abstract：:More than 50% of the Xenopus pectoralis twitch muscle fibers with two distant endplates are innervated at both sites by the same neuron. This study indicates that there are three separable twitch motor unit types in this muscle which show very little overlap in innervation. This study also shows that each motor unit i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90697-3
更新日期：1985-03-25 00:00:00
abstract：:The effects of dexmedetomidine, a highly selective alpha(2)-adrenoceptor agonist, on extracellular dopamine (DA) concentrations in the nucleus accumbens of awake rats were collected via in vivo cerebral microdialysis and measured using HPLC with electrochemical detection. The administration of dexmedetomidine (DEX) at...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03012-8
更新日期：2001-11-16 00:00:00
abstract：:The mesencephalic reticular formation (MRF) of cats anesthetized with N2O was stimulated electrically, and the effects of this stimulation on activity in the striate cortex were studied. The variations of intra- and extracellularly recorded unit activity and the changes in the extracellular potassium concentration wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90576-x
更新日期：1976-01-30 00:00:00
abstract：:Hyperacusis, a marked intolerance to normal environmental sound, is a common symptom in patients with tinnitus, Williams syndrome, autism, and other neurologic diseases. It has been suggested that an imbalance of excitation and inhibition in the central auditory system (CAS) may play an important role in hyperacusis. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.008
更新日期：2012-11-16 00:00:00
abstract：:We showed immunohistochemically the localization of 5 alpha-reductase-containing cells in the rat brain, using a rabbit antibody generated against 5 alpha-reductase rat type 1. The antibody was produced by injecting the synthetic peptide corresponding to the amino acids 38-53 of 5 alpha-reductase rat type 1, conjugate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00188-6
更新日期：1996-05-25 00:00:00
abstract：:The effects of caffeine ingestion and exposure to bright light, both separately and in combination, on salivary melatonin and tympanic temperature were assessed in humans. Four treatments during a 45.5 h sleep deprivation period were compared: Dim Light-Placebo, Dim Light-Caffeine, Bright Light-Placebo and Bright-Ligh...
journal_title：Brain research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0006-8993(96)01268-1
更新日期：1997-01-30 00:00:00
abstract：:C3H/HeJ mice are refractory to lipolysaccharide (LPS) in the periphery, primarily because their macrophages do not respond to LPS and produce pro-inflammatory cytokines such as interleukin-1 (IL-1). To determine if they are also refractory to LPS in the brain, behavior of C3H/HeJ mice was compared to LPS-sensitive C3H...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01454-0
更新日期：1997-03-28 00:00:00
abstract：:An in vitro preparation was used to determine if rapidly transported radiolabeled protein which is isolated with the myelin fraction of frog sciatic nerves is similar to rapidly transported radiolabeled protein released from sciatic nerves. Sciatic nerves along with their eighth and ninth dorsal root ganglia were plac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90525-x
更新日期：1982-05-13 00:00:00
abstract：:Applying light mechanical stimulations to the oral structures, multi-unit recordings (MUR) were performed, and receptive fields of neurons were defined in the somatosensory cortex S I of the cat. Oral representation was confirmed in the circumscribed area of the anterior coronal gyrus rostral to the facial area in the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90739-6
更新日期：1987-04-14 00:00:00
abstract：:Sleep deprivation leads to cognitive impairments in humans and, if sustained for 2-3 weeks in rats, it is invariably fatal. It has been suggested that neural activity associated with waking, if it is not interrupted by periods of sleep, may damage brain cells through excitotoxic or oxidative mechanisms and eventually ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01768-0
更新日期：1999-09-04 00:00:00
abstract：:To assess the role of androgen-dependent brain vasopressinergic transmission in the modulation of social recognition, castrated male rats which are deficient in vasopressin were implanted intracerebroventricularly with an Accurel collodion mini-device containing 10 micrograms vasopressin (AVP) whereas intact male rats...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90480-w
更新日期：1992-02-14 00:00:00
abstract：:Horeradish peroxidase was injected at multiple sites in the mandibular and sublingual salivary glands in order to label the preganglionic salivatory neurons in the brain stem. The same injections resulted in retrograde labeling of the sympathetic and sensory neurons that project to these glands. Labeled fusiform and m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90092-x
更新日期：1980-05-12 00:00:00
abstract：:Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.034
更新日期：2012-08-27 00:00:00
abstract：:Bcl-2 has been hypothesized to regulate many cellular functions in addition to its well-characterized role in the prevention of programmed cell death. To understand the role of Bcl-2 in regulating cell morphology and to explore the mechanism of this effect, we examined the effects of Bcl-2 overexpression on the morpho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.017
更新日期：2006-09-27 00:00:00
abstract：:Cells in layers II-III or VI were activated by microdrop application of acetylcholine (ACh), while monitoring the intracellular response of layer V pyramidal cells. This enabled the tracing of functional connections between the cells of layers II-III or VI with those of layer V. ACh activation of layer II-III or VI ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90811-m
更新日期：1992-03-06 00:00:00
abstract：:We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.097
更新日期：2005-04-25 00:00:00
abstract：:The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90784-6
更新日期：1994-12-15 00:00:00
abstract：:Neuropeptide K (NPK), a member of the kassinin-like tachykinin family, is contained in the rat hypothalamus and is known to stimulate pituitary ACTH release. The intraperitoneal bolus administration of NPK dose-dependently enhanced corticosterone blood level not only in intact rats, but also in hypophysectomized/ACTH ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91185-1
更新日期：1994-10-24 00:00:00
abstract：:Antagonism of NMDA-mediated transmission by MK-801 has been shown to block long-term potentiation (LTP) in vitro and delay electrical kindling of the amygdala. The present experiment sought to examine the relationship between synaptic potentiation of the perforant path-granule cell synapse and development of perforant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90064-i
更新日期：1990-06-11 00:00:00
