Bcl-2 overexpression disrupts the morphology of PC12 cells through reduced ERK activation.

abstract：:The studies were performed on operation material from 17- to 63-year-old patients and on fetuses at 19-23 weeks gestational age. Formaldehyde histofluorescence showed the presence of numerous perivascular adrenergic nerves around pial and intracerebral vessels, the carotid system being better supplied than the vertebr...

journal_title：Brain research

authors： Edvinsson L,Owman C,Sjöberg NO

更新日期：1976-10-22 00:00:00

abstract：:We studied whether, similarly to the auditory modality, short-period temporal integration processes occur in vision. Event-related potentials (ERP) were recorded for occasional stimulus omissions from sequences of patterned visual stimuli. A posterior negative component emerged only when the constant stimulus onset as...

journal_title：Brain research

authors： Czigler I,Winkler I,Pató L,Várnagy A,Weisz J,Balázs L

更新日期：2006-08-09 00:00:00

abstract：:The substance P content, glutamic acid decarboxylase and choline acetyltransferase activities and the level of [3H]diprenorphine binding were measured in various regions of the lumbar spinal cord of rats after unilateral section of the sciatic nerve or after dorsal rhizotomy. Sciatic nerve section produced a 75--80% d...

journal_title：Brain research

authors： Jessell T,Tsunoo A,Kanazawa I,Otsuka M

更新日期：1979-05-25 00:00:00

abstract：:Pyruvate carboxylase is the predominant anaplerotic enzyme in CNS tissues, and thus provides for net utilization of glucose to generate citric acid cycle intermediates such as alpha-ketoglutarate and malate for replenishment of the neurotransmitter pools of glutamate, GABA and aspartate. Studies reported in this paper...

journal_title：Brain research

authors： Shank RP,Bennett GS,Freytag SO,Campbell GL

更新日期：1985-03-11 00:00:00

abstract：:The active and passive properties of petrosal ganglion sensory neurons with axons in the glossopharyngeal nerve were examined with intracellular microelectrodes in an in vitro preparation. Glossopharyngeal neurons could be classified into two groups: H-cells showing an inflexion or hump on the falling phase of the spi...

journal_title：Brain research

authors： Morales A,Ivorra I,Gallego R

更新日期：1987-01-20 00:00:00

abstract：:By using immunocytochemistry we tested whether neurotransmitters, and enzymes specific to neurotransmitters synthesis are rhythmically expressed in the suprachiasmatic nuclei of the hypothalamus of Ruin lizards Podarcis sicula either kept in light-dark cycles or constant darkness. Within the suprachiasmatic nuclei, pr...

journal_title：Brain research

authors： Magnone MC,Bertolucci C,Piazza F,Foà A

更新日期：2003-05-23 00:00:00

abstract：:Erythropoietin (EPO) provides neuroprotection and neurorestoration after traumatic brain injury (TBI). The EPO doses used for treatment of TBI significantly increase hematocrit, which may affect the efficacy of EPO therapy for TBI. The aim of this study was to investigate whether normalization of hematocrit would affe...

journal_title：Brain research

authors： Zhang Y,Xiong Y,Mahmood A,Meng Y,Qu C,Schallert T,Chopp M

更新日期：2009-10-19 00:00:00

abstract：:Sodium and potassium currents in the node of Ranvier decrease exponentially with time during long lasting voltage clamp experiments. This decline is strongly dependent on temperature (Q10 approximately 3). Thiamine and, particularly, its diand triphosphoric acid esters are shown to prevent this exponential decline of ...

journal_title：Brain research

authors： Fox JM,Duppel W

更新日期：1975-05-23 00:00:00

abstract：:Stimulation of cardiac sympathetic afferents evokes excitatory cardiovascular reflexes. However, the exact regions in the brain that integrate these reflexes have not been identified. Expression of c-Fos in the neurons provides a useful marker of the activated neurons. In the present study, we examined the response of...

journal_title：Brain research

authors： Guo ZL,Lai HC,Longhurst JC

更新日期：2002-01-18 00:00:00

abstract：:A short-acting non-barbiturate intravenous general anaesthetic, etomidate, when administered i.v. lowered serum prolactin levels in the rat. The effect was evident at rest, after surgical stress or after injection of 5-hydroxytryptophan. Haloperidol-induced hyperprolactinaemia was not modified. Administered via the in...

journal_title：Brain research

authors： Preziosi P,Cerrito F,Vacca M

更新日期：1983-07-25 00:00:00

abstract：:Chemical (C) kindling by means of repeated spaced injections into the amygdala (AM) of a subconvulsive dose of L-glutamate and L-aspartate combined in a molar ratio of 1:3. (Glu/Asp) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled Stage 5 seizur...

journal_title：Brain research

authors： Mori N,Wada JA

更新日期：1987-11-03 00:00:00

abstract：:The radioprotective thiophosphate S-2(3 amino-propyl-amino) phosphorothioic acid (WR 2721) induced an early reduction of striatal acetylcholinesterase activity followed by an increase, when intraperitoneally injected to rats, although it does not cross the blood-brain barrier. These results were obtained using an orig...

journal_title：Brain research

authors： Clarençon D,Galonnier M,Testylier G,Fatôme M

更新日期：1993-04-09 00:00:00

abstract：:In the present report the effects of postpuberal gonadectomy on vomeronasal organ (VO) morphology were studied. Postpuberal gonadectomy induced in both male and female rats a decrement in the height of the epithelium and in the nuclear size of the bipolar neurons. These results show that the maintenance of neurosensor...

journal_title：Brain research

authors： Segovia S,Paniagua R,Nistal M,Guillamon A

更新日期：1984-06-01 00:00:00

abstract：:Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocamp...

journal_title：Brain research

authors： Yuan Y,Chen Z,Li L,Li X,Xia Q,Zhang H,Duan Q,Zhao Y

更新日期：2017-11-15 00:00:00

abstract：:MPTP is a neurotoxin thought to damage dopaminergic neurons through free radical formation. MPTP is metabolized in the brain to MPP(+), which is taken up into dopaminergic neurons via the dopamine transporter and assumed to impair mitochondrial function. We used striatal synaptosomes and telencephalic mitochondria to ...

journal_title：Brain research

authors： Fonck C,Baudry M

更新日期：2003-06-13 00:00:00

abstract：:Plectin is associated with intermediate filaments, such as glial fibrillary acidic protein (GFAP) and vimentin, which have an important role in the glial reactions after lesions. The present study investigates the plectin immunoreactivity following stab wounds in the cortex and the underlying white matter of adult rat...

journal_title：Brain research

authors： Kálmán M,Szabó A

更新日期：2000-02-28 00:00:00

abstract：:Neurons (n = 107) were recorded, in anaesthetized rats, with extracellular micropipettes, in the nucleus centralis of the amygdala (Ce). The activity of a large majority (77%) was exclusively or preferentially affected by noxious stimuli applied in any area of the body. The rest of the neurons was not activated by any...

journal_title：Brain research

authors： Bernard JF,Huang GF,Besson JM

更新日期：1990-07-23 00:00:00

abstract：:The present study was undertaken to investigate in rats the role of the noradrenergic innervation of the hippocampus in the reversal by antidepressant drugs of escape failures caused by previous exposure to inescapable shocks (learned helplessness design). Rats were either sham-operated or given a bilateral infusion o...

journal_title：Brain research

authors： Soubrie P,Martin P,el Mestikawy S,Hamon M

更新日期：1987-12-29 00:00:00

abstract：:The study makes an attempt to find out the action of norepinephrine (NE) and phenoxybenzamine (PB), applied at medial preoptic area (mPOA), in altering the sleep-awake responses, in free moving rats, which has not yet been reported. Effects of application of NE during day and PB during night, at mPOA, on sleep-awake r...

journal_title：Brain research

authors： Mohan Kumar V,Datta S,Chhina GS,Gandhi N,Singh B

更新日期：1984-11-26 00:00:00

abstract：:Neurotensin (NT), a tridecapeptide, is a neurotransmitter that elicits potent effects including hypothermia and antinociception in mice and rats. To date, there are two types of the neurotensin receptor (NTR) that have been molecularly cloned from the rat. However, several lines of evidence suggest the presence of add...

journal_title：Brain research

authors： Tyler BM,Cusack B,Douglas CL,Souder T,Richelson E

更新日期：1998-05-11 00:00:00

abstract：:The discontinuous terminal distributions of thalamo- and nigrostriatal axons were examined in adjacent tissue sections from single cat brains by combined anterograde labeling with tritiated proline autoradiography and wheat germ-horseradish peroxidase histochemistry. Injection of one tracer into the centromedian-paraf...

journal_title：Brain research

authors： Beckstead RM

更新日期：1985-05-27 00:00:00

abstract：:Male Long-Evans rats were administered nicotine bitartrate or sodium tartrate either during adolescence (p29-43) or adulthood (p80-94). Route of administration was via subcutaneously implanted osmotic pump (initial dose 2.0 mg/kg/day, free base). Five weeks following nicotine administration, brains were processed for ...

journal_title：Brain research

authors： McDonald CG,Eppolito AK,Brielmaier JM,Smith LN,Bergstrom HC,Lawhead MR,Smith RF

更新日期：2007-06-02 00:00:00

abstract：:Serotonin (5-HT) immunostained sections were analyzed using integrated optical density (IOD) measures obtained throughout the dorsal raphe nucleus (DRN) in Mongolian gerbils at selected times during a 12:12 h light:dark cycle. Substantial diurnal variation occurred in 5-HT neuronal staining density, with lowest and hi...

journal_title：Brain research

authors： Birkett M,Fite KV

更新日期：2005-02-09 00:00:00

abstract：:The particular vulnerability of hippocampal CA3/CA4 neurons to intracerebroventricularly administered kainate did not occur in rats until postnatal day 16. Glutamate applied in the same way failed to show comparable neurodegenerative signs, even when administered in large doses to adult animals. Alternatively, both ka...

journal_title：Brain research

authors： Wolf G,Keilhoff G

更新日期：1984-05-01 00:00:00

abstract：:This study analyzed the effects of pre-existing hyperglycemia on the extracellular levels of glutamate, other amino acids and free fatty acids, including arachidonic acid, in the ischemic/reperfused rat cerebral cortex, using a cortical cup technique. Forebrain cerebral ischemia (20 min) was induced by four vessel occ...

journal_title：Brain research

authors： Phillis JW,Song D,O'Regan MH

更新日期：1999-08-07 00:00:00

abstract：:In a previous study, male rats showed behavioural deficits after a single restraint stress but not after 5 daily restraint periods (i.e. adaptation had developed): female rats although less affected by single restraint failed to adapt over the same time course. This sex difference was associated with the male but not ...

journal_title：Brain research

authors： Haleem DJ,Kennett G,Curzon G

更新日期：1988-08-23 00:00:00

abstract：:More than 50% of the Xenopus pectoralis twitch muscle fibers with two distant endplates are innervated at both sites by the same neuron. This study indicates that there are three separable twitch motor unit types in this muscle which show very little overlap in innervation. This study also shows that each motor unit i...

journal_title：Brain research

authors： Nudell B,Grinnell AD

更新日期：1985-03-25 00:00:00

abstract：:It is widely believed that substance use disorder (SUD) results from both pre-alterations (vulnerability) and/or post-alterations (drug effects) on cortico-striatal circuits. These circuits are essential for cognitive control, motivation, reward dependent learning, and emotional processing. As such, dysfunctions in co...

journal_title：Brain research

authors： Kravitz AV,Tomasi D,LeBlanc KH,Baler R,Volkow ND,Bonci A,Ferré S

更新日期：2015-12-02 00:00:00

abstract：:The inhibitory effect of different concentrations of lithium (0.15-10 x 10(-3) M) on cAMP production induced by isoprenaline (1 x 10(-4) M) after the blockade of alpha(2)-adrenoceptors in the rat cerebral cortex was investigated. Low lithium concentrations (0.3-0.6 x 10(-3) M) exerted a significant inhibitory effect a...

journal_title：Brain research

authors： Laura Cuffi M,Carbonell L,Mármol F,Giménez J,Forn J

更新日期：2003-12-19 00:00:00

abstract：:Following electrophysiological techniques we investigated whether wallerian degeneration of the cat sural nerve may be influenced by (1) its peripheral connection and (2) the distance from the cell body. Distal stumps connected to their innervation sites peripherally showed less degeneration than proximal ones when is...

journal_title：Brain research

authors： Delgado-Lezama R,Muñoz-Martínez EJ

更新日期：1990-08-13 00:00:00