Abstract：
:A short-acting non-barbiturate intravenous general anaesthetic, etomidate, when administered i.v. lowered serum prolactin levels in the rat. The effect was evident at rest, after surgical stress or after injection of 5-hydroxytryptophan. Haloperidol-induced hyperprolactinaemia was not modified. Administered via the intracerebroventricular route, etomidate strongly reduced serum prolactin levels in unanesthetized rats. Studies performed on superfused synaptosomes from brain areas rich in dopaminergic nerve endings did not show any influence of the etomidate, 10(-7) M-10(-6) M, on [3H]dopamine release. A peculiar GABA-like mechanism and/or possible interplay with serotonergic control of the prolactin release may be postulated in order to explain the suppressive effects of the drug on secretion of lactotrophs.
journal_name
Brain Resjournal_title
Brain researchauthors
Preziosi P,Cerrito F,Vacca Mdoi
10.1016/0006-8993(83)90306-2subject
Has Abstractpub_date
1983-07-25 00:00:00pages
379-85issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90306-2journal_volume
271pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:In this paper we report on the effects of intra-VTA infusion of opioid agonists on rat ingestive behavior in a variety of experimental contexts. When the animals were tested outside of their home cages surrounded only by food-pellets (Experiment 1), the injection of the mu-opioid agonist DAMGO, but not the kappa-opioi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01281-l
更新日期：1995-01-30 00:00:00
abstract：:The influence of glutamate and aspartate on the time course of decay of excitatory currents at neuromuscular junctions of locust skeletal muscle was examined. Both aspartate (up to 10 mM) and glutamate (up to 0.3 mM) had little influence on the decay time of the synaptic currents, whether measured intracellularly by v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91020-3
更新日期：1980-06-16 00:00:00
abstract：:The light green cells (LGCs) in the central nervous system of the pond snail Lymnaea stagnalis form a homogeneous group of neuroendocrine cells that are involved in the control of growth and metabolism. These cells are inhibited by dopamine and the neuropeptides APGWamide, FMRFamide and GGSLFRFamide. Thus, the LGCs fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01096-2
更新日期：1997-11-28 00:00:00
abstract：:Recent evidence suggests that the primary visual cortex (V1) of rodents expresses surprisingly high levels of plasticity into adulthood. For example, long-term potentiation (LTP) is readily induced in the mature V1 of adult rodents in vivo. Here, adult, urethane-anesthetized rats were used for a detailed characterizat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.006
更新日期：2012-12-07 00:00:00
abstract：:Immunocytochemical and immunoblotting technique have been used to characterize the antigens recognized by two monoclonal antibodies (MAbs C6 and D5) produced against dissociated cells from punches of neonatal supraoptic (SON) and paraventricular (PVN) hypothalamic nuclei of the rat. Peroxidase immunocytochemistry reve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91281-5
更新日期：1991-04-05 00:00:00
abstract：:We have developed a sensitive enzymatic-immunoassay to quantify the level of gamma-enolase (a specific neuronal enzyme) which is released from cultured cells after exposure to various toxins. We show that this method can estimate selectively neuronal cell death without significantly interfering with glial cell death. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91264-f
更新日期：1992-10-09 00:00:00
abstract：:The total number of neurosensory cells in the mouse vomeronasal organ was estimated during postnatal development by counting the cell density and measuring the total volume of the neurosensory cell layer. There is a 43% increase in neurosensory cell number between 1 and 4 months of age, followed by a 21% fall in cell ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90675-7
更新日期：1980-03-03 00:00:00
abstract：:Antisera against rat-liver S-adenosylhomocysteine hydrolase (SAH-hydrolase) and calf intestinal mucosal adenosine deaminase (ADA) were raised in rabbits and subsequently used to determine the distribution of the corresponding enzymes in rat-brain using the peroxidase-antiperoxidase immunohistochemical procedure. SAH-h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90480-4
更新日期：1986-04-09 00:00:00
abstract：:Equivalent antiinflammatory doses of steroids including betamethasone, methylprednisolone and dexamethasone were administered in the neonatal period in a rat model. In situ cell death in hippocampus quantified by Terminal Deoxynucleated Transferase Nick-End Labeling and on ratio of brain to body weight was investigate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.051
更新日期：2009-01-23 00:00:00
abstract：:In the present study, receptor specific compounds were infused via a microdialysis probe in the vicinity of the right locus coeruleus (LC). During the infusion of these compounds, the extracellular content of noradrenaline was recorded in the ipsilateral medial prefrontal cortex (mPFC) with a second microdialysis prob...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01062-8
更新日期：1999-03-27 00:00:00
abstract：:The 'wobbler' mutant mouse can be recognized at about 4 weeks of age by its tremor and atrophy of forelimb muscles. In addition to degeneration of spinal motoneurons, especially in cervical spinal cord, selected bulbar motoneurons have also been reported to degenerate in the mutant. We examined a cranial motor nucleus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91363-1
更新日期：1987-02-24 00:00:00
abstract：:Magnetic resonance spectroscopy (MRS) has demonstrated age-related changes in brain metabolites that may underlie micro-structural brain changes, but few studies have examined their relationship with cognitive decline. We performed a cross-sectional study of brain metabolism and cognitive function in 82 healthy adults...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.06.027
更新日期：2007-08-20 00:00:00
abstract：:Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02462-3
更新日期：2001-06-22 00:00:00
abstract：:The number of adults in the US affected by bipolar disorder, depression, or schizophrenia is approaching 15 million. Despite decades of research, etiologies of these illnesses remain elusive. Theories of aberrant brain morphology, neurotransmission, and signal conduction have provided the heuristic framework for a lar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.048
更新日期：2006-08-04 00:00:00
abstract：:The effects of adenosine on the voltage-sensitive delayed-rectifier K+ (IK) currents and hyperpolarization-activated cationic inward current (Ih) were studied in cultured frog melanotrophs using the whole-cell configuration of the patch-clamp technique. The A1 receptor agonist R-N6-phenylisopropyl-adenosine (R-PIA; 50...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00184-x
更新日期：1998-05-18 00:00:00
abstract：:Spontaneous figure reversal of ambiguous patterns was analyzed in humans. A) With Necker-"cube"-like, or "drum"-like figures, having square or round shaped "front" and "rear" surfaces, and either large or small "depth", the perceptual intervals corresponding to both interpretations of "drum" were longer than those of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.064
更新日期：2008-08-15 00:00:00
abstract：:Ramified microglial cells were investigated in primary cultures of dissociated cerebral cortical tissue from rats. The identification of these cells was confirmed through immunohistochemical staining with 7 monoclonal antibodies selective for microglia. While there was significant variation in staining intensity with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91118-k
更新日期：1991-05-10 00:00:00
abstract：:Following single injections of horseradish peroxidase (HRP) in the superior colliculus (SC) and [3H]proline in the striate cortex of rats, a close correspondence was observed in the topographical arrangements of extrastriate cortical fields of HRP retrograde label and of isotope anterograde label. These results suppor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90318-3
更新日期：1982-06-24 00:00:00
abstract：:Bradykinin is known to rapidly elevate intracellular calcium leading to secretion of neurotransmitters and short term activation of tyrosine hydroxylase (TH). In this study we examined the effect of bradykinin on mRNA levels of two catecholamine biosynthetic enzymes. Treatment of PC12 cells with 1 microM bradykinin fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91477-a
更新日期：1993-04-16 00:00:00
abstract：:Glucagon like peptide-1 (7-36) amide (GLP-1), a potent regulator of glucose homeostasis, is also produced in the central nervous system and has been implicated in the control of hypothalamic-pituitary function and food intake. GLP-1 immunoreactive (IR) fibers and terminals are widely distributed in the septum, hypotha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03117-2
更新日期：2003-09-26 00:00:00
abstract：:Bilateral 6-hydroxydopamine microinjections into the substantia nigra abolished both the locomotor and stereotyped responses to d-amphetamine in adult rats. The lesions resulted in a depletion of over 99 per cent of striatal tyrosine hydroxylase activity (indicating a near total lesion of the nigro-striatal dopamine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90834-3
更新日期：1975-01-17 00:00:00
abstract：:The cholinergic innervation of the mediodorsal (MD) nucleus of the thalamus was visualized immunohistochemically in human brain postmortem, using an antibody against human choline acetyltransferase (ChAT). The ChAT staining of the MD nucleus was more intense than in the surrounding thalamic nuclei but weaker than that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90585-y
更新日期：1990-05-07 00:00:00
abstract：:In this study, the effects of early vs. delayed tPA treatment on the development of hemorrhagic transformation was compared in a rat thromboembolic model of stroke. Fibrinolysis was performed by administering tPA intravenously at 2 or 6 h after ischemic onset. Twenty-four hours later, confluent hemorrhagic infarction ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02276-3
更新日期：2000-01-31 00:00:00
abstract：:Axons in the adult mammalian CNS normally do not regenerate following axotomy even though they retain the capacity for growth under certain experimental conditions. Although this implies that the regeneration of adult axons is under regulative control, very little is known about the signaling pathways "responsible" fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01468-3
更新日期：1996-04-01 00:00:00
abstract：:Tuberohypophysial dopamine (DA) neurons terminate in the intermediate and neural lobes of the posterior pituitary. The objective of this study was to determine if concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC), a major metabolite of DA in these regions, reflect the activity of tuberohypophysial DA neurons. T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91209-y
更新日期：1990-01-01 00:00:00
abstract：:Glucocorticoids (GCs) predispose hippocampal neurons to damage during metabolic stressors. One component of hippocampal GC-endangerment may be changes in neuronal defenses against oxidative challenge. Previous experiments showed a decrease in basal levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and glutathione...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00104-8
更新日期：1998-04-27 00:00:00
abstract：:Many of our everyday actions are only appropriate in certain situations and selecting the appropriate behavior requires that we use current context and previous experience to guide our decisions. The current study examined hippocampal functional connectivity with prefrontal and striatal regions during a task that requ...
journal_title：Brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brainres.2011.09.038
更新日期：2011-11-14 00:00:00
abstract：:Neurons are distinctive in that they are generally considered to be permanently post-mitotic cells. The oncoprotein p53 is a key regulator in neuronal development, notably in cell proliferation and neuronal death. We hypothesize that p53 maintains the post-mitotic characteristic of differentiated neurons. New lines of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04119-7
更新日期：2003-03-07 00:00:00
abstract：:The distribution of glucagon-like peptide-1-(7-36)amide like immunoreactivity (GLP-1-(7-36)NH2 IR) in rat brain was determined. Highest concentrations were found in the hypothalamus. A combination of gel chromatography and anion exchange chromatography showed that the majority of hypothalamic immunoreactivity exactly ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90628-8
更新日期：1989-11-20 00:00:00
abstract：:Previous studies on the processing of fractions and proportions focused mainly on the processing of their overall magnitude information in the intraparietal sulcus (IPS). However, the IPS is also associated with domain-general cognitive functions beyond processing overall magnitude, which may nevertheless be involved ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.02.029
更新日期：2019-07-01 00:00:00
