Abstract:
:Equivalent antiinflammatory doses of steroids including betamethasone, methylprednisolone and dexamethasone were administered in the neonatal period in a rat model. In situ cell death in hippocampus quantified by Terminal Deoxynucleated Transferase Nick-End Labeling and on ratio of brain to body weight was investigated. Apoptotic index (AI) was significantly higher in methylprednisolone, and high dose dexamethasone groups than the other groups. AI in "Cornu ammonis 1" (CA1) and "Cornu ammonis 3" (CA3) subregions of high dose dexamethasone group was the highest among the five groups tested. AI in CA3 subregions of methylprednisolone group was also significantly higher than the control, betamethasone and low dose dexamethasone groups. AI in CA1 subregion were not different among control, betamethasone, methylprednisolone and low dose dexamethasone groups. In addition, high dose dexamethasone resulted significant decrease in the ratio of brain weight to body weight in comparison to all other groups tested. In conclusion, betamethasone and low dose dexamethasone may be better alternative treatments among agents tested in this study for chronic lung disease (CLD).
journal_name
Brain Resjournal_title
Brain researchauthors
Duksal F,Kilic I,Tufan AC,Akdogan Idoi
10.1016/j.brainres.2008.10.051subject
Has Abstractpub_date
2009-01-23 00:00:00pages
75-80eissn
0006-8993issn
1872-6240pii
S0006-8993(08)02570-5journal_volume
1250pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Extracellular ATP can influence cells via activation of P2X purinoceptors, the distribution of which can be altered in the central and peripheral nervous systems following injury or tissue damage. Here we have investigated the effect of a unilateral section of the cervical vagus nerve on the distribution of P2X(1), P2...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02797-5
更新日期:2003-07-04 00:00:00
abstract::The understanding of sentences involves not only the retrieval of the meaning of single words, but the identification of the relation between a verb and its arguments. The way the brain manages to process word meaning and syntactic relations during language comprehension on-line still is a matter of debate. Here we re...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2006.08.038
更新日期:2007-05-18 00:00:00
abstract::Clinically, phenytoin is thought to be useful in controlling seizure activity by preventing it's spread from the focus to neighboring tissue. Experimentally, it has been suggested that phenytoin's principal action is no longer polysynaptic pathways with primary foci affected less than surrounding tissue. In this study...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90994-6
更新日期:1984-03-19 00:00:00
abstract::The effects of oral administration of the neuroleptic, haloperidol, on regional brain concentrations of cholecystokinin (CCK) and neurotensin were examined in the rat. Both short-term (3 weeks) and long-term (8 months) haloperidol administration increased the concentration of CCK in the substantia nigra. While short-t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91580-1
更新日期:1989-02-20 00:00:00
abstract::We recorded from the visual cortex of 4 groups of monocularly deprived kittens. Three groups were treated with intraventricular 6-hydroxydopamine (6-OHDA) at different times relative to monocular deprivation (MD). One group received only vehicle solution and MD. 6-OHDA caused the greatest decrease in plasticity in the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90137-4
更新日期:1987-03-01 00:00:00
abstract::The distribution of retinotectal afferents has been studied by autoradiography in 4 adult cats. The findings suggest that crossed and uncrossed retinal fibers terminate in a striking cluster-and-sheet pattern that varies systematically with respect to the retinotopic map of the colliculus. Following unilateral eye inj...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90566-1
更新日期:1975-10-10 00:00:00
abstract::In this report, using a push-pull perfusion technique, we examined in vivo the effects of exogenous dopamine (DA) on the output of neurochemical substances from the caudate nucleus (CN) of freely behaving rats. Exogenous DA, at concentrations of 10(-5) M, 5 x 10(-5) M and 10(-4) M, in modified Krebs-Ringer phosphate m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90803-2
更新日期:1989-03-06 00:00:00
abstract::Hypothalamic control of thermoregulatory evaporation has been examined in hydrated and dehydrated cats exposed to warm ambient temperatures. Reduction in evaporative cooling during dehydration is associated with increased hypothalamic temperature. Local thermal stimulation of the hypothalamus indicates that the thermo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90120-7
更新日期:1981-02-09 00:00:00
abstract::Previous research has shown that, in freely moving laboratory rats, the odors of benzyl alcohol, camphor, carvacrol, isopentenyl methyl sulfide, 2-propylthietane, salicylaldehyde, trimethylthiazoline, and xylene (plus other compounds) elicit high amplitude bursts of roughly 20-Hz waves (beta-waves) in the olfactory bu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03225-5
更新日期:2002-01-11 00:00:00
abstract::Neurons located in the nucleus raphe magnus (NRM), a region important in the control of nociception, appear to be tonically inhibited by noradrenergic (NA) neurons. Anatomical studies have suggested that the A5 catecholamine nucleus may be the primary source of noradrenergic neurons whose terminals are located in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91108-x
更新日期:1986-04-02 00:00:00
abstract::The analgesic effect of clonidine in spontaneously hypertensive rats (SHR) and in normotensive Sprague-Dawley (SD) rats was assessed by using the formalin pain test. The analgesic response of SD rats to low doses (15-60 micrograms/kg i.p.) but not to a high dose (150 micrograms/kg i.p.) of clonidine was inhibited by n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91630-2
更新日期:1989-02-13 00:00:00
abstract::Gonadal steroids have previously been shown to enhance neuritic outgrowth from mouse preoptic area explants in vitro. To examine effects within the explant proper, dendritic fields of Golgi-stained neurons of estradiol-treated and untreated cultures were compared quantitatively. Neurons of gonadal steroid-treated cult...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90085-8
更新日期:1983-03-01 00:00:00
abstract::Application of the cholinergic agonist, carbachol, produced theta-like rhythmical waveforms, recorded in the stratum moleculare of the dentate gyrus in the cat hippocampal formation slices. This effect of carbachol was antagonized by atropine but not D-tubocurarine. These results provide first direct evidence that the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90223-v
更新日期:1992-04-24 00:00:00
abstract::The substantia nigra pars reticulata (SNr) receives both inhibitory GABAergic and excitatory glutamatergic afferents from diverse origins. Ischemic injury to the striatum and/or the globus pallidus causes delayed transneuronal death of the SNr neurons, in the course of which neuronal disinhibition induced by loss of G...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01052-9
更新日期:1996-12-16 00:00:00
abstract::The location of stapedius motoneurons in the rat was determined with horseradish peroxidase (HRP) retrograde tracing techniques. After injection of free HRP or wheat germ agglutinin-horseradish peroxidase (WGA-HRP) in the stapedius muscle on one side, labeled neurons were seen ipsilaterally in a region ventromedial to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91532-1
更新日期:1989-01-02 00:00:00
abstract::Afferent pathways innervating the urinary bladder consist of myelinated Adelta- and unmyelinated C-fibers, the neuronal cell bodies of which correspond to medium and small-sized cell populations of dorsal root ganglion (DRG) neurons, respectively. Since hyperpolarization-activated cyclic nucleotide-gated cation (HCN) ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.08.052
更新日期:2006-11-13 00:00:00
abstract::17β-estradiol (E2 or estrogen) is an endogenous steroid hormone that is well known to exert neuroprotection. Along these lines, one mechanism through which E2 protects the hippocampus from cerebral ischemia is by preventing the post-ischemic elevation of Dkk1, a neurodegenerative factor that serves as an antagonist of...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2012.12.015
更新日期:2013-06-13 00:00:00
abstract::The effects of microinjection of alpha-noradrenergic agonists and antagonists in the flocculus on the basic gain and adaptibility of vestibulo-ocular and optokinetic responses were investigated. A complementary, previous investigation had shown that the adaptation, but not the basic performance, of compensatory oculom...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90623-4
更新日期:1991-10-25 00:00:00
abstract::We identified cell bodies of a pair of the cardio-inhibitory (CI) neurons in the first thoracic ganglion (TG1) of Bathynomus doederleini. Each of the cell bodies gives rise to a single axon, which runs into the contralateral hemiganglion of TG1 via the commissure and runs to the heart via the fourth root as CI axon. S...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90789-x
更新日期:1991-09-06 00:00:00
abstract::The production and localization of cell-associated forms of beta-amyloid precursor protein (APP) of Alzheimer's disease was investigated in primary cultures of mouse glial cells. In both oligodendrocytes and astrocytes, immunofluorescence staining with an antibody against the carboxy terminus of APP revealed an intens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90898-j
更新日期:1992-07-03 00:00:00
abstract::This study investigates the reanalysis processes as a consequence of conflict between incompatible sentential representations in sentence comprehension. Using the event-related potential (ERP) technique, we examined the situation in which the sentential representation built upon world knowledge (i.e., the plausibility...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.090
更新日期:2008-04-08 00:00:00
abstract::Multiple retrograde fluorescent tracing was employed to investigate the organization of the rat entopeduncular nucleus projections to the lateral habenula, ventral anterior-ventral lateral thalamus, parafasicular-centre median complex, and tegmenti pedunculopontis area of the brain stem. The results indicate that neur...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90064-0
更新日期:1981-04-27 00:00:00
abstract::To address the question of whether fine myelinated and unmyelinated primary afferent fibers contribute to the mechanism of presynaptic inhibition in the spinal cord, we studied dorsal root-evoked dorsal root potentials (DR-DRPs) using a newly developed longitudinal spinal cord slice preparations in the adult rat. Sing...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00619-2
更新日期:1995-09-11 00:00:00
abstract::Excitatory amino acids (EAAs) are likely to play a key role in sensory transmission in the spinal cord. In the present study, the microiontophoresis technique was used to investigate the effects of L-glutamate (GLUT), N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor antagonist, AP-7, on...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90991-4
更新日期:1991-02-22 00:00:00
abstract::Ablation of tissue regions, specific genes, or specific cell types represent important means of studying function in the nervous system. Here we summarize recent experience using a strategy for the genetically-targeted and conditionally regulated ablation of astroglial cells in different parts of the nervous system. T...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/s0006-8993(99)01639-x
更新日期:1999-07-17 00:00:00
abstract::Iontophoretic application of carbachol caused excitation of CA1 neurones and decreased the amplitude of antidromic CA1 population spikes recorded extracellularly. Adenosine, adenosine triphosphate (ATP) and the purine analogues N-ethylcarboxamide adenosine (NECA) and R- and S-phenylisopropyladenosine (PIA) reduced the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90501-x
更新日期:1988-08-16 00:00:00
abstract::This study describes the development and establishment of pure cerebrovascular smooth muscle cells derived from dissociated cells of microvessels obtained from brains of rats. The cultured and propagated vascular smooth muscle cells display histochemical and ultrastructural characteristics of smooth muscle cells consi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90073-2
更新日期:1983-12-05 00:00:00
abstract::The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat were determined. These afferent fibers had conduction velocities ranging from 0.5-23.5 m/s (Mode = 0.5 m/s; Median = 1 m/s). Sixty-six percent of the fibers had conduction velocities less than 2.5 m/s and were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91244-b
更新日期:1990-09-03 00:00:00
abstract::Chemical synaptic transmission was studied with microelectrode techniques in isolated frog cerebella maintained in vitro. Purkinje cell (PC) EPSPs, elicited by selective monosynaptic electrical stimulation of both the parallel fiber (PF) and climbing fiber (CF) inputs, could be inverted by depolarizing (outward) curre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)91005-2
更新日期:1976-09-10 00:00:00
abstract::Unit activity of locus coeruleus (LC) neurons in rats was investigated. After the animal recovered from anesthesia, the spontaneous activity exhibited periodic bursting discharges at about 15-30 s intervals. The oscillation was observed to last for a long time (1-3 h). It is suggested that many LC neurons exhibited th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90540-6
更新日期:1982-05-13 00:00:00