Genetically-targeted and conditionally-regulated ablation of astroglial cells in the central, enteric and peripheral nervous systems in adult transgenic mice.

abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...

journal_title：Brain research

authors： Baptista T,Araujo de Baptista E,Ying Kin NM,Beaulieu S,Walker D,Joober R,Lalonde J,Richard D

更新日期：2002-12-06 00:00:00

abstract：:The effects of bilateral intracranial injections of the D-1 dopamine receptor antagonist SCH 23390 HCl (0, 0.8, 1.6, 3.2, and 6.4 microgram total bilateral dose) administered into the dorsolateral bed nucleus of the stria terminalis (dlBNST) immediately prior to a 3 h intravenous cocaine self-administration session we...

journal_title：Brain research

authors： Epping-Jordan MP,Markou A,Koob GF

更新日期：1998-02-16 00:00:00

abstract：:This study assessed the contribution of K+ conductances to dopamine (DA)-induced modulation of evoked depolarizing synaptic responses (DPSPs) in neostriatal slices obtained from rats. Intracellular recordings of membrane properties and DPSPs evoked by local electrical stimulation were obtained from cells bathed in sta...

journal_title：Brain research

authors： Altemus KL,Levine MS

更新日期：1996-04-29 00:00:00

abstract：:The effect of neuroprotective drugs on the early and late electrophysiological manifestations of photothrombotic occlusion of distal branches of middle cerebral artery was studied in rats treated with MK-801 and Cerebrolysin (CL). DC potentials were recorded from the irradiated cortex (ischemic core), from the adjacen...

journal_title：Brain research

authors： Koroleva VI,Korolev OS,Loseva E,Bures J

更新日期：1998-03-09 00:00:00

abstract：:The spinal cord dorsal horn contains neural mechanisms which can greatly facilitate pain. We have recently shown that 'illness'-inducing agents, such as intraperitoneally administered lipopolysaccharide (LPS; bacterial endotoxin), can produce prolonged hyperalgesia. This hyperalgesic state is mediated at the level of ...

journal_title：Brain research

authors： Watkins LR,Wiertelak EP,Furness LE,Maier SF

更新日期：1994-11-21 00:00:00

abstract：:Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The rem...

journal_title：Brain research

authors： Charpak S,Armstrong WE,Mühlethaler M,Dreifuss JJ

更新日期：1984-05-21 00:00:00

abstract：:Missense mutations of presenilin 1 (PS-1) and presenilin 2 (PS-2) genes cause the majority of early-onset familial forms of Alzheimer's disease (AD). We previously characterized the distribution of the PS-1 protein in the mouse brain by immunohistochemistry using an antibody directed against an epitope located in the ...

journal_title：Brain research

authors： Blanchard V,Czech C,Bonici B,Clavel N,Gohin M,Dalet K,Revah F,Pradier L,Imperato A,Moussaoui S

更新日期：1997-05-30 00:00:00

abstract：:The choroid plexus (CP) performs the vital function of producing up to 90% (450-1000 ml/day) of cerebrospinal fluid (CSF) to nourish and to protect the brain in the CSF suspension. The CP also acts as a selective barrier between blood and CSF to regulate ions and other essential molecules. However, the accumulation of...

journal_title：Brain research

authors： Wen GY,Wisniewski HM,Kascsak RJ

更新日期：1999-06-19 00:00:00

abstract：:The nucleus of the solitary tract (NTS) is a critical structure involved in coordinating autonomic and visceral activities. Previous independent studies have demonstrated efferent projections from the NTS to the nucleus paragigantocellularis (PGi) and the central nucleus of the amygdala (CNA) in rat brain. To further ...

journal_title：Brain research

authors： Reyes BA,Van Bockstaele EJ

更新日期：2006-10-30 00:00:00

abstract：:To investigate the possible mechanisms by which neurons in the caudate-putamen (CPu) and globus pallidus (GP) participate in pain and nociception, the present study characterized the response properties of CPu and GP neurons to non-noxious and noxious thermal stimuli in anesthetized rats. Nociceptive CPu and GP neuron...

journal_title：Brain research

authors： Chudler EH

更新日期：1998-11-23 00:00:00

abstract：:The effects of medial septal lesions on latent inhibition (LI) were assessed in a conditioned taste aversion paradigm. Animals were tested in a LI paradigm 2 weeks after receiving medial septal or sham lesions. The LI paradigm involved a pre-exposure phase in which water-deprived rats were allowed access to either wat...

journal_title：Brain research

authors： Turgeon SM,Kegel G,Davis MM

更新日期：2001-02-02 00:00:00

abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...

journal_title：Brain research

authors： Zhang Y,Shen GL,Shangguan LJ,Yu Y,He ML

更新日期：2015-05-22 00:00:00

abstract：:Small iontophoretic application of wheat-germ-agglutinin conjugated to horseradish peroxidase, was used to simultaneously observe, in the rat, the afferent and the efferent connections of the cuneiformis nucleus (Cnf), in the same animal. The results demonstrate that the main Cnf afferent connections originate from: (...

journal_title：Brain research

authors： Bernard JF,Peschanski M,Besson JM

更新日期：1989-06-19 00:00:00

abstract：:Surgical tissue samples of the human dentate gyrus were immunostained for glutamate decarboxylase (GAD), the gamma-aminobutyric acid (GABA)-synthesizing enzyme, and studied by both light and electron microscopy. Immunoreactive neurons and terminals displayed similar morphological characteristics as known from studies ...

journal_title：Brain research

authors： Schlander M,Thomalske G,Frotscher M

更新日期：1987-01-13 00:00:00

abstract：:The retrograde transport of fluorescent substances was used in order to investigate divergent axon collaterals of neurons in the nucleus prepositus hypoglossi (Ph). Fast blue (FB) was injected into the flocculus, paraflocculus and/or the vermis, while nuclear yellow (NY) was injected into the oculomotor nucleus alone ...

journal_title：Brain research

authors： Yingcharoen K,Rinvik E

更新日期：1982-08-19 00:00:00

abstract：:The effect of a dihydropyridine Ca2+ antagonist, cilnidipine, on voltage-dependent Ca2+ channels was studied in acutely dissociated rat CA1 pyramidal neurons using the nystatin-perforated patch recording configuration under voltage-clamp conditions. Cilnidipine had no effect on low-voltage-activated (LVA) Ca2+ channel...

journal_title：Brain research

authors： Murai Y,Uneyama H,Ishibashi H,Takahama K,Akaike N

更新日期：2000-01-31 00:00:00

abstract：:In order to establish the cellular and subcellular localization of the chemokine protein, vascular endothelial growth factor (VEGF) or vascular permeability factor, in adult human retina, we employed immunocytochemistry with double immunolabeling, using a primary antibody to amino acids 1-10 of VEGF, together with ant...

journal_title：Brain research

authors： Famiglietti EV,Stopa EG,McGookin ED,Song P,LeBlanc V,Streeten BW

更新日期：2003-04-18 00:00:00

abstract：:In a whole mount preparation of the hooded rat retina, stained with methylene blue, the ganglion cell density was counted over the retina. The density ranged from 6200-6500/sq.mm to 1000-1500/sq.mm. The area with a density higher than 6000/sq.mm was called the central area and was centered at about 1 mm (20 degrees) a...

journal_title：Brain research

authors： Fukuda Y

更新日期：1977-01-07 00:00:00

abstract：:Oxytocin properties have been studied in different experimental models in order to obtain evidence for its analgesic properties. The analgesic effect of an oxytocinergic pathway descending from the hypothalamus reaching the dorsal horn of the spinal cord has been studied. In anesthetized rats, we recorded single units...

journal_title：Brain research

authors： Condés-Lara M,Rojas-Piloni G,Martínez-Lorenzana G,Rodríguez-Jiménez J,López Hidalgo M,Freund-Mercier MJ

更新日期：2006-04-07 00:00:00

abstract：:In the present study, the role of medial septal receptors in behaviour-induced increase in acetylcholine (ACh) release in hippocampus was investigated using dual-probe microdialysis in combination with a simple behavioural procedure. gamma-Aminobutyric acid (GABA) and glutamate receptor agonists and antagonists were a...

journal_title：Brain research

authors： Moor E,Schirm E,Jacsó J,Westerink BH

更新日期：1998-04-06 00:00:00

abstract：:By ligating specific nerves in the cat, the central processes of the nodose ganglion (NG) cells containing substance P-like immunoreactive materials were shown, immunohistochemically, to run through the cross-anastomosis made between the cranial end of the NG and the caudal end of the superior cervical ganglion (SCG),...

journal_title：Brain research

authors： Hayashi H,Ohsumi K,Fujiwara M,Mizuno N

更新日期：1983-06-27 00:00:00

abstract：:The organization and representation of conceptual knowledge in the brain remains a controversial issue in terms of both neuropsychological and imaging evidence. We report the results of a functional magnetic resonance study in which the role of the most debated dimensions (domain and feature type) was evaluated throug...

journal_title：Brain research

authors： Marques JF,Canessa N,Siri S,Catricalà E,Cappa S

更新日期：2008-02-15 00:00:00

abstract：:Nocistatin, a product of the same precursor as nociceptin/orphanin FQ (N/OFQ), has been shown to antagonize effects of N/OFQ. N/OFQ stimulates feeding, most probably by inhibiting activation of neurons containing oxytocin (OT) and vasopressin (VP), peptides considered as satiety factors, and implicated in the developm...

journal_title：Brain research

authors： Olszewski PK,Shaw TJ,Grace MK,Billington CJ,Levine AS

更新日期：2000-07-28 00:00:00

abstract：:Beta-amyloid peptide (Aβ) has a causal role in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that Aβ can disrupt excitatory glutamatergic synaptic function at synaptic level. However, the underlying mechanisms remain obscure. In this study, we recorded evoked and spontaneous EPSCs in hippoca...

journal_title：Brain research

authors： Yao W,Zou HJ,Sun D,Ren SQ

更新日期：2013-06-17 00:00:00

abstract：:Single unit discharges in the superior secondary gustatory nucleus of the carp, Cyprinus carpio L., were studied electrophysiologically in response to chemical stimulation of the external chemoreceptors of the facial skin surface. Of 36 gustatory neurons recorded, 80.6% were facilitated by taste stimuli and 19.4% were...

journal_title：Brain research

authors： Marui T

更新日期：1981-07-27 00:00:00

abstract：:A histo-enzymatic technique for visualizing and quantifying endogenous NAD(H) in brain tissue was developed, based on coupled enzymatic cycling reactions that reduce nitrotetrazolium blue chloride to produce formazan. Conditions were used where the endogenous level of nicotinamide adenine dinucleotides (NAD(H)) was th...

journal_title：Brain research

authors： Balan IS,Fiskum G,Kristian T

更新日期：2010-02-26 00:00:00

abstract：:Signaling pathways underlying the cognitive deficit of the Alzheimer's disease (AD) are not completely understood. Protein kinase C (PKC), a major neuronal protein plays a critical role in cellular signal transduction and it is known to be subjected to modulation in AD. We showed previously that, chronic infusion of b...

journal_title：Brain research

authors： Olariu A,Yamada K,Mamiya T,Hefco V,Nabeshima T

更新日期：2002-12-13 00:00:00

abstract：:The effects of unilateral naris closure on the olfactory bulbs of adult mice were assessed quantitatively by measuring four parameters. Naris closures were performed when animals were at least 5 months of age and lasted for 4-8 months. The first parameter measured was mitral cell number, which revealed that there was ...

journal_title：Brain research

authors： Henegar JR,Maruniak JA

更新日期：1991-12-24 00:00:00

abstract：:Patients with sickle cell disease (SCD) can develop strokes and as a result, present neurologic and neurocognitive deficits. However, recent studies show that even without detectable cerebral parenchymal abnormalities on imaging studies, SCD patients can have significant cognitive and motor dysfunction, which can pres...

journal_title：Brain research

authors： Almeida LEF,Wang L,Kamimura S,Zerfas PM,Smith ML,Neto OLA,Vale T,Quezado MM,Horkayne-Szakaly I,Wakim P,Quezado ZMN

更新日期：2020-11-01 00:00:00

abstract：:We have previously demonstrated resiniferatoxin (RTX) to be an ultrapotent analog of capsaicin. Like capsaicin, RTX initially induces neurogenic inflammation, pain, and hypothermia and then causes desensitization of these responses. We examine here the duration of desensitization following acute treatment with the max...

journal_title：Brain research

authors： Szallasi A,Joo F,Blumberg PM

更新日期：1989-11-27 00:00:00