Abstract：
:Extracellular recordings were obtained from spontaneously active neurones located in the dorsal motor nucleus of vagus nerve ( DMX ) in slices of the rat brainstem. Oxytocin applied to the bath at concentrations of 10(-7) M or 10(-6) M excited 79% of these cells in a concentration-dependent, reversible manner. The remaining cells were unaffected. The stimulatory effect of oxytocin was reversibly antagonized by a synthetic structural analogue known to block the peripheral, endocrine effects of neurohypophysial peptides. A selective oxytocic agonist was as potent as oxytocin, whereas vasopressin exerted a much weaker effect. We therefore suggest that neurones located in DMX are endowed with receptors for oxytocin.
journal_name
Brain Resjournal_title
Brain researchauthors
Charpak S,Armstrong WE,Mühlethaler M,Dreifuss JJdoi
10.1016/0006-8993(84)91342-8subject
Has Abstractpub_date
1984-05-21 00:00:00pages
83-9issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(84)91342-8journal_volume
300pub_type
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