Abstract：
:The effects of medial septal lesions on latent inhibition (LI) were assessed in a conditioned taste aversion paradigm. Animals were tested in a LI paradigm 2 weeks after receiving medial septal or sham lesions. The LI paradigm involved a pre-exposure phase in which water-deprived rats were allowed access to either water (non-pre-exposed; NPE) or 5% sucrose (pre-exposed; PE), followed by a conditioning phase in which animals were allowed access to sucrose and subsequently injected with lithium chloride, and a test phase in which animals were allowed access to both sucrose and water. LI was assessed by comparing the %-sucrose consumed in PE and NPE groups on the test day. There was a significantly greater LI effect in the lesion group than in the sham group, suggesting that electrolytic lesions to the medial septum can enhance LI in a CTA paradigm.
journal_name
Brain Resjournal_title
Brain researchauthors
Turgeon SM,Kegel G,Davis MMdoi
10.1016/s0006-8993(00)03192-9subject
Has Abstractpub_date
2001-02-02 00:00:00pages
333-7issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)03192-9journal_volume
890pub_type
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