Abstract：
:The effects of subchronic administration of the antidepressant fluoxetine (15 mg/kg i.p., 14 days) on thyroid hormone metabolism were investigated in 11 regions of the CNS and three peripheral tissues in the rat. Fluoxetine significantly enhanced the activity of the 5'II-deiodinase isoenzyme (5'D-II), which catalyzes the deiodination of the inactive prohormone thyroxine (T4) to the active compound triiodothyronine (T3) in areas of the cortex, the limbic forebrain and the striatum. The activity of the 5D-III deiodinase isoenzyme (5D-III), which catalyzes the further deiodination of T3 to the inactive metabolite 3,3'-T2, was inhibited in the first two of these areas. The areas affected were roughly the same as those with the highest density of 5-HT2 receptors in rat brain. Theoretically, the enhancement 5'D-II activity, together with a concomitant decrease in 5D-III activity, should lead to a rise in T3 concentrations. Whether or not these effects are involved in the as yet unknown mechanism of action of this antidepressant compound is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Baumgartner A,Dubeyko M,Campos-Barros A,Eravci M,Meinhold Hdoi
10.1016/0006-8993(94)91424-9subject
Has Abstractpub_date
1994-01-28 00:00:00pages
68-74issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91424-9journal_volume
635pub_type
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