Abstract:
:Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus. Based upon the absence of co-localization with the non-neuronal markers GFAP (astroglial) and OX42 (microglial), it appears that GLUT8 is expressed exclusively in neurons. At the cellular level, GLUT8 immunofluorescence was localized to neuronal cell bodies and the most proximal dendrites of inhibitory and excitatory neurons while GLUT3 immunofluorescence was localized to the neuropil in the hippocampus. These results demonstrate that GLUT8 is a neuron-specific glucose transporter expressed in the neuronal cell bodies of excitatory and inhibitory neurons in the rat hippocampus.
journal_name
Brain Resjournal_title
Brain researchauthors
Reagan LP,Rosell DR,Alves SE,Hoskin EK,McCall AL,Charron MJ,McEwen BSdoi
10.1016/s0006-8993(02)02308-9subject
Has Abstractpub_date
2002-04-05 00:00:00pages
129-34issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302023089journal_volume
932pub_type
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