Abstract：
:The effect of the sulfonamide derivative sulthiame (Ospolot) on voltage-operated sodium channels was investigated in acutely isolated neurons from the guinea pig hippocampus using the whole-cell patch-clamp technique. Sulthiame in a concentration of 10 microg/ml reduced the inactivating sodium currents without affecting potassium currents. The effect was not dependent on voltage. At therapeutic concentration of 1 to 10 microg/ml sodium currents were reduced by 13 to 25% of control. Reductions of this size (induced by the specific sodium channel blocker tetrodotoxin or by 10 microg/ml sulthiame itself) impaired repetitive generation of action potentials and reduced the maximum discharge frequency by 20 to 40%. In summary, the anticonvulsant drug sulthiame exerts blocking effects on sodium channels which can be assumed to be anticonvulsant and to be different from the effects induced by blockade of carbonic anhydrase.
journal_name
Brain Resjournal_title
Brain researchauthors
Madeja M,Wolf C,Speckmann EJdoi
10.1016/s0006-8993(01)02262-4subject
Has Abstractpub_date
2001-05-04 00:00:00pages
88-94issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02262-4journal_volume
900pub_type
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