Extracellular calcium alters frequency modulation of [3H]acetylcholine release from rat hippocampal slices.

abstract：:The effects of the epileptogenic agent, penicillin, on excitatory and inhibitory postsynaptic potentials (EPSPs and IPSPs) were studied in the hippocampal in vitro slice preparation. The actions of penicillin were compared to those of bicuculline, an antagonist of gamma-aminobutyric acid. Neither substance enhanced mo...

journal_title：Brain research

authors： Schwartzkroin PA,Prince DA

更新日期：1980-02-03 00:00:00

abstract：:The dtsz mutant hamster represents a model of primary paroxysmal dystonia, in which dystonic episodes occur in response to stress. Previous examinations demonstrated striatal dysfunctions in dtsz hamsters. In the present study, in situ hybridization was used to examine preproenkephalin and prodynorphin expression as p...

journal_title：Brain research

authors： Nobrega JN,Parkes JH,Wong P,Raymond R,Richter A

更新日期：2004-07-23 00:00:00

abstract：:To examine the hypothesis that the increased adrenocortical activity during lactation induced the loss of the prolactin (PRL) -releasing effect of morphine, we studied the effect of morphine in adrenalectomized (ADX) and sham-operated primiparous lactating Wistar rats. Animals were adrenalectomized 4 days after delive...

journal_title：Brain research

authors： Kiem DT,Fekete MI,Bartha L,Nagy G,Makara GB

更新日期：1991-11-01 00:00:00

abstract：:The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...

journal_title：Brain research

authors： Anezaki T,Yanagisawa K,Takahashi H,Nakajima T,Miyashita K,Ishikawa A,Ikuta F,Miyatake T

更新日期：1992-03-06 00:00:00

abstract：:Hyperprolinemia type II is an autosomal recessive disorder caused by the severe deficiency of delta(1)-pyrroline-5-carboxylate dehydrogenase activity leading to tissue accumulation of proline (Pro). Most patients detected so far show neurological manifestations including epilepsy and mental retardation, whose pathophy...

journal_title：Brain research

authors： Delwing D,Bavaresco CS,Chiarani F,Wannmacher CM,Wajner M,Dutra-Filho CS,de Souza Wyse AT

更新日期：2003-11-21 00:00:00

abstract：:A water soluble benzodiazepine, clorazepate, has been used to establish the point of benzodiazepine proliferative arrest in the rat C6 glioma. Clorazepate inhibited C6 proliferation in a dose-dependent manner with an IC50 value of 280 microM, as judged by a nuclei counting procedure. Release of cells from a 48 h expos...

journal_title：Brain research

authors： Maguire C,O'Connell C,Regan CM

更新日期：1992-09-11 00:00:00

abstract：:Glioblastoma multiform is the most common malignant primary brain tumor in adults, but there remains no effective therapeutic approach. 2-methoxyestradiol (2-ME), which is a naturally occurring metabolite of 17beta-estradiol, was shown to enhance radiotherapeutic effect in certain tumors; however, whether 2-ME can als...

journal_title：Brain research

authors： Zou H,Zhao S,Zhang J,Lv G,Zhang X,Yu H,Wang H,Wang L

更新日期：2007-12-14 00:00:00

abstract：:The compound m-chlorophenylpiperazine (m-CPP) is used clinically to manipulate serotonergic function, though its precise mechanisms of actions are not well understood. m-CPP alters synaptic transmission and neuronal function in vertebrates by non-selective agonistic actions on 5-HT(1) and 5-HT(2) receptors. In this st...

journal_title：Brain research

authors： Sparks GM,Brailoiu E,Brailoiu GC,Dun NJ,Tabor J,Cooper RL

更新日期：2003-04-18 00:00:00

abstract：:The mouse auditory neurons, hair cells and their supporting cells in the cochlea are considered to be generated mainly in the embryonic days and to be sustained throughout the whole life. In the present study, however, we observed that auditory ganglion cells in the spiral ganglia undergo apoptosis and mitosis in the ...

journal_title：Brain research

authors： Kamiya K,Takahashi K,Kitamura K,Momoi T,Yoshikawa Y

更新日期：2001-05-18 00:00:00

abstract：BACKGROUND:Toll-like receptor 4 (TLR4) is an important mediator of the innate immune response. It significantly contributes to neuroinflammation and may be involved in ischemic tolerance. It is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whe...

journal_title：Brain research

authors： Feng R,Li S,Li F

更新日期：2011-04-12 00:00:00

abstract：:Fetal mouse dorsal root ganglion (DRG) neurons were maintained in primary dissociated cell culture for periods of 7 days to 3 months. Intracellular recordings from these cells revealed the presence of spontaneous subthreshold potentials in 101/177 neurons studied. When measured at the resting membrane potential, these...

journal_title：Brain research

authors： Mathers DA,Barker JL

更新日期：1984-02-13 00:00:00

abstract：:Selective D1 (SCH-23390) and D2 (eticlopride and sulpiride) dopamine receptor antagonists were assessed for their ability to reverse the effects of 1.0 mg/kg D-amphetamine on excitatory motor-related neurons in the striatum of freely moving rats. SCH-23390 (0.125, 0.25, 0.5 and 1.0 mg/kg) rapidly and consistently bloc...

journal_title：Brain research

authors： Rosa-Kenig A,Puotz JK,Rebec GV

更新日期：1993-08-13 00:00:00

abstract：:There was a distinct sex-related difference in the anterior pituitary level of substance P-like immunoreactivity (SP-LI) in adult rats; the anterior pituitaries of male rats contained a higher concentration of SP-LI than those of females. Neonatal castration (day 1) resulted in a marked decrease of the SP-LI level in ...

journal_title：Brain research

authors： Yoshikawa K,Hong JS

更新日期：1983-08-29 00:00:00

abstract：:Excitatory amino acid neurotoxicity and the inflammatory response are suspected as mediators of some of the pathological sequelae occurring as a result of spinal cord injury. Here we report temporal and regional increases of the NMDA receptor agonist, quinolinic acid (QUIN), in an experimental model of spinal contusio...

journal_title：Brain research

authors： Popovich PG,Reinhard JF Jr,Flanagan EM,Stokes BT

更新日期：1994-01-07 00:00:00

abstract：:Gulf War Illness (GWI) is a chronic disease that affects the 1991 Gulf War (GW) veterans for which treatment is lacking. It has been hypothesized that drugs used to protect military personnel from chemical attacks and insects during the war: pyridostigmine bromide (PB),N, N-diethyl-m-toluamide (DEET), and permethrin (...

journal_title：Brain research

authors： Carreras I,Aytan N,Mellott T,Choi JK,Lehar M,Crabtree L,Leite-Morris K,Jenkins BG,Blusztajn JK,Dedeoglu A

更新日期：2018-02-15 00:00:00

abstract：:gamma-Aminobutyric acid (GABA), pentobarbital and ethanol were applied by bath superfusion to rat locus coeruleus (LC) neurons in a brain slice preparation. The GABA-induced current and conductance increase was measured with single-electrode voltage clamp. Pentobarbital potentiated the GABA-induced current and conduct...

journal_title：Brain research

authors： Osmanović SS,Shefner SA

更新日期：1990-05-28 00:00:00

abstract：:Preganglionic sympathetic neurons were labelled by retrograde transport of horseradish peroxidase, while catecholamine axon varicosities were marked by the uptake of 5-hydroxydopamine in the intermediolateral nucleus of the rat. The direct synaptic contacts from the catecholamine axons to the preganglionic sympathetic...

journal_title：Brain research

authors： Chiba T,Masuko S

更新日期：1986-08-20 00:00:00

abstract：:Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...

journal_title：Brain research

authors： Prezioso PJ,Neale JH

更新日期：1983-12-12 00:00:00

abstract：:The distribution of alpha scorpion toxin (alpha-ScTx) receptors was examined in differentiated mouse neuroblastoma cell cultures (N IE 115 clone) by electron microscope autoradiography using [125I]alpha-ScTx. This neurotoxin binds specifically to voltage-sensitive sodium channels, slowing down the inactivation of the ...

journal_title：Brain research

authors： Cau P,Massacrier A,Boudier JL,Couraud F

更新日期：1985-05-13 00:00:00

abstract：:The lateral hypothalamus (LH) is a site of integration for control mechanisms of feeding behavior as it has extensive reciprocal connections with multiple intrahypothalamic and extrahypothalamic brain areas. Evidence suggests that blockade of ionotropric gamma-aminobutyric acid (GABA) receptors in the LH elicits eatin...

journal_title：Brain research

authors： Turenius CI,Charles JR,Tsai DH,Ebersole PL,Htut MH,Ngo PT,Lara RN,Stanley BG

更新日期：2009-08-04 00:00:00

abstract：:Characteristics of neural corticosteroid receptors were studied in 51 adrenally-intact macaque monkeys using a modification of a corticosteroid receptor assay developed in this laboratory for rodent studies. Using cortisol as a ligand, two receptor subtypes could be distinguished and with similar Kd's to those observe...

journal_title：Brain research

authors： Brooke SM,de Haas-Johnson AM,Kaplan JR,Sapolsky RM

更新日期：1994-02-21 00:00:00

abstract：:Previous studies using the technique of microinjection into brain nuclei indicated that the periaqueductal gray (PAG), nucleus accumbens, habenula and amygdala play an essential role in pain modulation and that these nuclei possibly act through a 'mesolimbic neural loop' to exert an analgesic effect, in which Met-enke...

journal_title：Brain research

authors： Ma QP,Han JS

更新日期：1991-12-06 00:00:00

abstract：:Alterations in neurotrophic signaling pathways may contribute to the changes in the mesolimbic dopamine system induced by chronic morphine exposure. In a rat model of morphine dependence, we previously identified increased levels of phospholipase C gamma-1 (PLCgamma1) immunoreactivity specifically within the ventral t...

journal_title：Brain research

authors： Wolf DH,Nestler EJ,Russell DS

更新日期：2007-07-02 00:00:00

abstract：:The mechanism(s) underlying age-associated diminutions in the rat striatal D2 dopamine receptor (D2-receptor) number was investigated. The levels of D2-receptor mRNA in 4-, 12- and 18-month-old rat striata were found not to change. In contrast, the levels of 110 kDa protein, labeled with a D2-receptor specific antibod...

journal_title：Brain research

authors： Sakata M,Farooqui SM,Prasad C

更新日期：1992-03-20 00:00:00

abstract：:The ability of heterotopic noxious stimuli to inhibit the activity of dorsal horn convergent neurones was investigated in both intact anesthetized, and spinal unanesthetized rats. Forty-four convergent neurones in lumbar dorsal horn were recognized by their ability to respond to both noxious and non-noxious natural st...

journal_title：Brain research

authors： Cadden SW,Villanueva L,Chitour D,Le Bars D

更新日期：1983-09-19 00:00:00

abstract：:The present experiments were performed to demonstrate in vivo the existence of a modulatory role of Na+ in the inhibitory control of prolactin (PRL) secretion. Groups of adult male rats were either adrenalectomized (adrenex) or sham-operated (normals) and implanted in the right atrium with a chronic cannula for the in...

journal_title：Brain research

authors： Collu R,Bouvier C

更新日期：1987-01-13 00:00:00

abstract：:The associative learning functions of the central nervous system of Limax maximus have been established with behavioral experiments on intact animals (Sahley et al., J. comp. Physiol., 144 (1981) 1) and physiological experiments on the isolated CNS (Culligan and Gelperin, Brain Research, 266 (1983) 319). We now report...

journal_title：Brain research

authors： Gelperin A,Culligan N

更新日期：1984-06-25 00:00:00

abstract：:The hypothalamic angiotensin II (Ang II) system plays an important role in pituitary hormone release. Little is known about this system in the mouse brain. We studied the distribution of angiotensin-converting-enzyme (ACE), Ang II, Ang II receptor subtypes, and vasopressin in the hypothalamus of adult male mice. Autor...

journal_title：Brain research

authors： Jöhren O,Imboden H,Häuser W,Maye I,Sanvitto GL,Saavedra JM

更新日期：1997-05-23 00:00:00

abstract：:The dominant pacemaker of the mammalian circadian clock, located in the suprachiasmatic nucleus (SCN), is of special interest for many pharmacological, physiological and immunohistological studies on angiotensins and their receptors. Based on its role in the circadian modulation of blood pressure and vasopressin relea...

journal_title：Brain research

authors： Thomas MA,Fleissner G,Stöhr M,Hauptfleisch S,Lemmer B

更新日期：2004-05-22 00:00:00

abstract：:Following electrophysiological techniques we investigated whether wallerian degeneration of the cat sural nerve may be influenced by (1) its peripheral connection and (2) the distance from the cell body. Distal stumps connected to their innervation sites peripherally showed less degeneration than proximal ones when is...

journal_title：Brain research

authors： Delgado-Lezama R,Muñoz-Martínez EJ

更新日期：1990-08-13 00:00:00