Abstract：
:The mouse auditory neurons, hair cells and their supporting cells in the cochlea are considered to be generated mainly in the embryonic days and to be sustained throughout the whole life. In the present study, however, we observed that auditory ganglion cells in the spiral ganglia undergo apoptosis and mitosis in the suckling mouse (1- to 2-week-old C3H/HeJ mice) with a normal auditory system. In spiral ganglia at postnatal days 7 (P7) and 10 (P10), TUNEL (TdT-mediated dUTP nick-end labeling)-positive and morphologically apoptotic ganglion cells were found. Furthermore, by bromodeoxyuridine labeling, mitosis of auditory ganglion cells was found at P10 to P14. In a functional study of auditory brainstem response, we demonstrated that the C3H/HeJ mouse acquires the ability to hear airborne sound at P12 and this is the same time as the opening of their external acoustic meatus (EAM). These results indicate that C3H/HeJ auditory ganglion cells have the ability to proliferate even after opening of the EAM and the initial input of airborne sound. We found that postnatal apoptosis and mitosis after P7 also occurred in the greater epithelial ridge (GER) which is an important organ for maturation of the organ of Corti and is located around the inner hair cells. This indicates that GER cells are not only degenerated but also regenerated until their disappearance around P12. This is the first report on mammals to demonstrate that neuronal mitosis of spiral ganglion cells and that of GER cells occur not only in embryonic and neonatal development but also in postnatal development of the normal auditory system.
journal_name
Brain Resjournal_title
Brain researchauthors
Kamiya K,Takahashi K,Kitamura K,Momoi T,Yoshikawa Ydoi
10.1016/s0006-8993(01)02300-9subject
Has Abstractpub_date
2001-05-18 00:00:00pages
296-302issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02300-9journal_volume
901pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:A pair of adult molluscan neurons (L5 and R5) are known to sprout and form a new electrical synapse following axotomy. Additionally, certain forms of stress can elicit restricted sprouting of neurons L5 and R5 within the intact nervous system. This study found that the strength of 5-5 electrical coupling was increased...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90759-0
更新日期：1985-09-23 00:00:00
abstract：:Transfer learning is an immanent feature of perceptual learning. Yet, despite the increasingly widespread application of transcranial direct current stimulation (tDCS) to study learning, transfer effects in response to tDCS have not been studied. Therefore, the present study investigated the transfer of tactile acuity...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.03.031
更新日期：2018-06-15 00:00:00
abstract：:The axonal transport of radiolabeled slow phase proteins and fast phase glycoproteins was studied in rabbit hypoglossal nerve one week after axotomy. The nerves were ligated and cut to prevent axonal regeneration into the distal stump. In this situation of obstructed axonal outgrowth, the axonal transport of these com...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90953-2
更新日期：1982-10-28 00:00:00
abstract：:Regulation of myelin protein gene expression in the presence and absence of myelin assembly can be assessed using crushed or permanently transected adult sciatic nerves of rats. The P0 glycoprotein and the myelin basic protein (MBP) are the major myelin-specific proteins of the peripheral nervous system. The steady-st...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(87)90021-0
更新日期：1987-04-01 00:00:00
abstract：:A potential mechanism for valproate (VPA)-induced increases in glial cell-substratum adhesivity has been demonstrated. Metabolically labelled glioma (C6) and primary astrocytes showed a statistically significant accumulation of protein when cultured in the presence of therapeutic concentrations of VPA (1 mM). This was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90292-2
更新日期：1988-08-30 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is characterized by a progressive degeneration of upper and lower motor neurons, resulting in fatal paralysis due to denervation of the muscle. Due to genetic, pathological and symptomatic overlap, ALS is now considered a spectrum disease together with frontotemporal dementia (FTD),...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2018.02.011
更新日期：2018-08-15 00:00:00
abstract：:Inorganic mercury (Hg2+) reduced voltage-gated calcium channel currents irreversibly in two different preparations. In cultured rat dorsal root ganglion (DRG) neurons, studied with the whole cell patch clamp technique, a rapid concentration-dependent decrease in the L/N-type currents to a steady state was observed wit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91146-j
更新日期：1993-12-31 00:00:00
abstract：:It has been well established that the mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) opener, diazoxide, has protective effects on the heart and brain following ischemia/reperfusion injury. However, the mechanism of the neuroprotective effects of diazoxide remains unclear. This study highlights the anti-apo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.11.019
更新日期：2011-01-25 00:00:00
abstract：:Extracellular single-unit activity was recorded from neurons of the internal and external pallidal segments, and from 'border cells' at the periphery of the segments, in 3 waking cynomolgus monkeys during electrical stimulation of 3 sites bilaterally in the striatum: one in the caudate nucleus and two in the putamen. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90394-6
更新日期：1989-09-25 00:00:00
abstract：:Current and voltage responses elicited by increasing or decreasing the concentration of L-glutamate or its analog kainate around isolated cone horizontal cells were measured with patch pipettes using the whole cell recording configuration. Application of these photoreceptor transmitter agonists induced inward currents...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90935-9
更新日期：1989-05-15 00:00:00
abstract：:Muscle spindles are induced during embryonic development by contact between sensory axons and undifferentiated myotubes. Neonatal guinea pigs deprived of nerve growth factor in utero can have only 15-20% of the normal number of dorsal root ganglion cells. This study demonstrates that such neonates have normal numbers ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90945-6
更新日期：1988-03-22 00:00:00
abstract：:The blockade of the lateral parabrachial nucleus (LPBN) with GABA(A) receptor agonist muscimol induces robust hypertonic NaCl and water intake by rats. In the present study we investigated the effects of previous injections of losartan (AT(1) angiotensin receptor antagonist) into the LPBN on 0.3M NaCl and water intake...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.06.004
更新日期：2011-07-27 00:00:00
abstract：:In an effort to further characterize the proteins of the auditory nerve, the effects of hair cell loss on rapidly transported proteins of the auditory nerve were studied. The effects were studied in the waltzing guinea pig, a genetically deaf animal which displays an age-dependent loss of sensory cells, and in normal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90693-x
更新日期：1982-12-16 00:00:00
abstract：:Somatosensory neurons including nociceptive ones in the medial thalamus have been studied extracellularly, and are classified into three types: nociceptive-specific, wide dynamic range, and tap neurons. However, the morphological characteristics of these three neurons have not yet been clarified. We studied the morpho...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91368-o
更新日期：1992-07-17 00:00:00
abstract：:Erythropoietin (EPO), a hematopoietic hormonal cytokine induced in response to hypoxia, has neuroprotective effects. EPO receptor (EPOR) is expressed in microglia, resident immune cells in the brain. However, the effect of EPO on microglial activation is not clear. In the present study, we demonstrated that the EPOR i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.02.023
更新日期：2017-05-01 00:00:00
abstract：:Vasopressinergic structures were examined within the magnocellular nuclei of the human basal forebrain. Vasopressinergic neurons were found in all parts of the diagonal band nucleus, and less frequently in the anteromedial subnucleus of the basal nucleus (Meynert). They belong to the group of large multipolar neurons,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90678-5
更新日期：1990-10-15 00:00:00
abstract：:Cerebrospinal fluid (c.s.f.) pressure and resistance to absorption have been studied in exteriorized fetuses (18 to 21 days gestation) from pregnant rats anaesthetised with pentobarbitone and in similarly anaesthetised postnatal rats at 1, 5, 10 and 30 days after birth and in adults. The resting c.s.f. pressure was lo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90172-6
更新日期：1987-05-01 00:00:00
abstract：:Effects of taurine on endogenous aspartic acid (Asp), glutamic acid (Glu) and gamma-aminobutyric acid (GABA) release has been investigated using synaptosomes prepared from rat cerebral cortex. Although basal release of these amino acids was not affected, taurine inhibited KCl (30 mM)-evoked overflow of Asp, Glu and GA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90318-h
更新日期：1993-11-12 00:00:00
abstract：:Recent evidence indicates that the superior colliculus (SC), in addition to its functions in sensory detection, also participates in controlling the generalized activation state of the forebrain, as measured by the electroencephalogram (EEG) or electrocorticogram (ECoG). The mechanisms by which the SC modulates forebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04062-3
更新日期：2003-02-21 00:00:00
abstract：:The major initiation process of intracranial aneurysms is thought to involve endothelial dysfunction due to hemodynamic stress. Angiotensin II type 1 receptor blockers and statins improve vascular endothelium function. The effects of olmesartan and pravastatin were investigated on the development of experimental aneur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.044
更新日期：2010-03-31 00:00:00
abstract：:Altered expression of neurotrophins may contribute to the pathogenesis of schizophrenia. Several studies suggest sex steroid hormones may be involved in the regulation of brain-derived neurotrophic factor (BDNF) signaling, as well as the symptoms of schizophrenia. This study aimed to identify sex differences in BDNF-T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.01.060
更新日期：2011-04-12 00:00:00
abstract：:Recently mutations in ubiquilin-2 were identified in patients with amyotrophic lateral sclerosis (ALS) and ALS/dementia providing direct evidence for the importance of this protein in neurodegenerative diseases. Histological studies have suggested that ubiquilin-1/-2 are associated with various pathological inclusions...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.06.006
更新日期：2013-08-02 00:00:00
abstract：:Unanesthetized adult male rats with indwelling right atrial cannulae were used in the majority of experiments. Morphine (MOR, 3.0 mg/kg) caused a large but transient increase in both GH and PRL levels, which could be prevented with naloxone. Disruption of central noradrenergic function with diethyldithiocarbamate (400...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91130-0
更新日期：1980-09-22 00:00:00
abstract：:A study was undertaken of the role of the external lateral parabrachial subnucleus (PBNLe) in flavor preferences induced by the intragastric administration of predigested/cephalic food. These preferences were developed using two different learning procedures, concurrent and sequential. In the concurrent procedure, two...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03032-9
更新日期：2002-09-20 00:00:00
abstract：:The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction product for detailed analysis in relation to normal cytoarchite...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90395-2
更新日期：1988-11-01 00:00:00
abstract：:Our recent researches have identified increased expression of miR-21-5p in rats brain following traumatic brain injury (TBI), which protected against blood-brain barrier (BBB) damage. To further study the mechanism underlying the role of miR-21-5p on alleviating BBB damage after TBI, we performed the scratch injury mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.07.015
更新日期：2016-11-01 00:00:00
abstract：:The neurite promoting factors in the astroglial conditioned medium (As-CM) were characterized by using primary cultures of embryonic rat neocortical neurons. The factors in the As-CM bind to lectins such as wheat germ agglutinin (WGA), suggesting that they contain sugar moieties. When the WGA-bound fractions were appl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91059-p
更新日期：1990-09-10 00:00:00
abstract：:Intraocular injections of several different retrograde tracers were made in albino rats. Retrogradely filled neurons were observed in two locations: the medial pretectal area and the contralateral periaqueductal grey matter, indicating that the pretectum and the mesencephalon are sources of centrifugal innervation to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90046-0
更新日期：1985-02-11 00:00:00
abstract：:To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90445-h
更新日期：1990-04-23 00:00:00
abstract：:Perinatal exposure to cannabinoids has been shown to elicit central nervous system impairment in rodents. This includes changes in monoaminergic and neuropeptidergic activities. We have examined the effect of perinatal exposure to delta 9-tetrahydrocannabinol (delta 9-THC) on sensitivity to radiant heat in both male a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00255-o
更新日期：1995-05-22 00:00:00
