Abstract：
:The blockade of the lateral parabrachial nucleus (LPBN) with GABA(A) receptor agonist muscimol induces robust hypertonic NaCl and water intake by rats. In the present study we investigated the effects of previous injections of losartan (AT(1) angiotensin receptor antagonist) into the LPBN on 0.3M NaCl and water intake induced by muscimol injected bilaterally in the same area in fluid replete rats and in rats treated with the diuretic furosemide combined with a low dose of the angiotensin-converting enzyme inhibitor captopril injected subcutaneously. Male Wistar rats with stainless steel cannulas implanted bilaterally into the LPBN were used. Bilateral injections of muscimol (0.5 nmol/0.2 μl, n=8) into the LPBN in fluid replete rats induced 0.3M NaCl intake (23.4±4.1 vs. saline: 0.4±0.4 ml/3h) and water intake (9.3±1.9 vs. saline: 0.7±0.4 ml/3h) and pre-treatment of the LPBN with losartan (50 μg/0.2 μl) reduced 0.3M NaCl intake (3.3±2.5 ml/3h) and water intake (4.0±2.9 ml/3h) induced by muscimol. In rats treated with furosemide+captopril, pre-treatment with losartan into the LPBN attenuated the increase of 0.3M NaCl intake produced by muscimol (12.8±5.3, vs. saline+muscimol: 36.7±6.7 ml/3h) without changing water intake. Therefore, the results suggest that deactivation of LPBN inhibitory mechanisms by muscimol injections into the LPBN is facilitated by endogenous angiotensin II acting on AT(1) receptors in the LPBN, which drives rats to ingest large amounts of hypertonic NaCl.
journal_name
Brain Resjournal_title
Brain researchauthors
Da Silva CZ,Menani JV,Callera JCdoi
10.1016/j.brainres.2011.06.004subject
Has Abstractpub_date
2011-07-27 00:00:00pages
28-36eissn
0006-8993issn
1872-6240pii
S0006-8993(11)01051-1journal_volume
1403pub_type
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