Neuropeptide Y-immunoreactive neurons receive synaptic inputs from dopaminergic axon terminals in the rat neostriatum.

abstract：:The effects of the 8-alpha-amino-ergoline CU 32-085 on central dopamine neuronal systems was investigated. Two h after administration of CU 32-085 a slight increase of dopamine levels was observed in the nucleus caudatus-putamen. Radioligand binding studies in vitro have shown that CU 32-085 has a low affinity for str...

journal_title：Brain research

authors： Fuxe K,Agnati L,Mascagni F,Kuga S,Helmer-Matyjek E,Goldstein M

更新日期：1985-03-04 00:00:00

abstract：:The mechanism of 3,4-methylenedioxymethamphetamine (d-MDMA)-induced neurotoxicity may involve formation of toxic radical species. Endogenous defenses against toxic radical species include tissue stores of vitamin E, and thiols. We examined whether vitamin E deficiency could alter d-MDMA-induced neurotoxicity by admini...

journal_title：Brain research

authors： Johnson EA,Shvedova AA,Kisin E,O'Callaghan JP,Kommineni C,Miller DB

更新日期：2002-04-19 00:00:00

abstract：:In situ hybridization (ISH) is an essential technique for mapping gene expression in the brain. Although many ISH protocols provide for quantitative analysis of individual mRNAs in different brain regions or across experimental conditions, this technique has lacked the necessary standardization for quantitative compar...

journal_title：Brain research

authors： Broide RS,Trembleau A,Ellison JA,Cooper J,Lo D,Young WG,Morrison JH,Bloom FE

更新日期：2004-03-12 00:00:00

abstract：:The purpose of this study is to reveal whether the application of immunohistochemical examinations to the peripheral nervous system (PNS) can be a reliable method for the quantitative analysis of the blood-nerve barrier (BNB) and the relationship between restoration of BNB and nerve regeneration. Sciatic nerves in rat...

journal_title：Brain research

authors： Omura K,Ohbayashi M,Sano M,Omura T,Hasegawa T,Nagano A

更新日期：2004-03-19 00:00:00

abstract：:The L-isomer of beta-N-methylamino-L-alanine (BMAA), present in free form in seed of Cycas circinalis, elicits in spinal cord cultures a pattern of acute postsynaptic neuronal vacuolation comparable to that induced by beta-N-oxalylamino-L-alanine (BOAA), an excitotoxic amino acid of greater potency isolated from seed ...

journal_title：Brain research

authors： Nunn PB,Seelig M,Zagoren JC,Spencer PS

更新日期：1987-05-05 00:00:00

abstract：:The distribution of inositol 1,4,5-trisphosphate (InsP3) 3-kinase was studied in the adult rat brain, using polyclonal antibodies raised against the purified 50,000-Da rat brain enzyme by immunohistochemistry and Western blot, in addition to enzymatic assay. Immunohistochemically, the enzyme was detected in neurons, w...

journal_title：Brain research

authors： Mailleux P,Takazawa K,Erneux C,Vanderhaeghen JJ

更新日期：1991-01-25 00:00:00

abstract：:There is no sex difference in the number of axodendritic synapses in the lateral septum of adult rats. However, the treatment of adult females with estradiol (E2) for 4 weeks increases significantly the number of synapses, whereas E2 treatment fails to increase the synaptic number in males, suggesting a possible sexua...

journal_title：Brain research

authors： Miyakawa M,Arai Y

更新日期：1987-12-08 00:00:00

abstract：:Neuropeptide Y (NPY) presynaptically inhibits excitatory transmission in area CA1 of rat hippocampus. As postsynaptic NPY receptors in certain other tissues have been shown to be coupled to G-proteins, we have tested the hypothesis that the hippocampal NPY effects are also mediated by G-proteins. Pretreatment of rats ...

journal_title：Brain research

authors： Colmers WF,Pittman QJ

更新日期：1989-09-25 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a devastating stroke with no clinically proven treatment. Deferoxamine (DFX), an iron chelator, is a promising therapy that lessens edema, mitigates peri-hematoma cell death, and improves behavioral recovery after whole-blood-induced ICH in rodents. In this model, blood is directly in...

journal_title：Brain research

authors： Warkentin LM,Auriat AM,Wowk S,Colbourne F

更新日期：2010-01-14 00:00:00

abstract：:Previous evidence suggests that preterm newborns with intrauterine growth restriction (IUGR) have specific neurostructural and neurodevelopmental anomalies, but it is unknown whether these effects persist in early childhood. We studied a sample of 18 preterm IUGR, 15 preterm AGA - born between 26 and 34 weeks of gesta...

journal_title：Brain research

authors： Padilla N,Falcón C,Sanz-Cortés M,Figueras F,Bargallo N,Crispi F,Eixarch E,Arranz A,Botet F,Gratacós E

更新日期：2011-03-25 00:00:00

abstract：:3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine and epinephrine. DOPEGAL, but not other metabolites, kills differentiated PC-12 cells. However, the type of DOPEGAL induced cell death, whether necrosis or apoptosis, is not known. To determine the type of cell death tr...

journal_title：Brain research

authors： Burke WJ,Schmitt CA,Miller C,Li SW

更新日期：1997-06-20 00:00:00

abstract：:The normal cellular prion protein (PrP(C)) plays an essential role in the development of prion diseases. Indirect evidence has suggested that different PrP(C) glycoforms may be expressed in different brain regions and perform distinct functions. However, due to a lack of monoclonal antibodies (Mabs) that are specific ...

journal_title：Brain research

authors： Liu T,Zwingman T,Li R,Pan T,Wong BS,Petersen RB,Gambetti P,Herrup K,Sy MS

更新日期：2001-03-30 00:00:00

abstract：:The present study examined the influences of dopamine (DA) receptor stimulation on enkephalin (Met5-enkephalin; ME) and tachykinin (substance P; SP) systems of basal ganglia of Sprague-Dawley rats, lesioned as neonates with 6-hydroxydopamine (6-OHDA). It has been proposed that the neonatal 6-OHDA-lesioned rat could se...

journal_title：Brain research

authors： Sivam SP

更新日期：1989-10-23 00:00:00

abstract：:Following a single intravitreal injection of 200 nmol of kainic acid (KA) to newly hatched chickens, there are acute and long-term effects on retinal ganglion cells in the chicken retina. Thirty min after injection, most ganglion cells showed cytoplasmic vacuolization. However, 14 days later, most ganglion cell soma a...

journal_title：Brain research

authors： Tung NN,Morgan IG,Ehrlich D

更新日期：1987-12-01 00:00:00

abstract：:The amplitude of the acoustic startle reflex can be modulated by exposure to aversive stimuli or other conditions which evoke a state of fear. The neurotransmitters involved in this modulation are currently being investigated. Unilateral local infusion of corticotropin-releasing hormone (CRH; 0, 10, 20, 40 and 80 ng) ...

journal_title：Brain research

authors： Birnbaum SG,Davis M

更新日期：1998-01-26 00:00:00

abstract：INTRODUCTION:Ischemic postconditioning (IpostC) has been described in both heart and brain. The first aim of this study was to evaluate the effects of IpostC on brain infarct size and neurological function in the middle cerebral artery occlusion (MCAO) model. The second aim was to determine the involvement of the mitoc...

journal_title：Brain research

authors： Robin E,Simerabet M,Hassoun SM,Adamczyk S,Tavernier B,Vallet B,Bordet R,Lebuffe G

更新日期：2011-02-23 00:00:00

abstract：:Recent pharmacological and morphological studies have raised the likelihood of a regulatory link between the neuropeptide Y (NPY) and beta-endorphin (beta-END) networks in the hypothalamus. To evaluate this link we have examined the effects of NPY administration on the in vivo release of beta-END by push-pull perfusio...

journal_title：Brain research

authors： Kalra PS,Norlin M,Kalra SP

更新日期：1995-12-24 00:00:00

abstract：:Circling training during rat striatum postnatal critical period (PN30 to 37 days) induces a life-lasting co-reduction of muscarinic acetylcholine receptors (mAChR) and dopamine D2 receptors (D2R) binding. Here, we evaluated the expression of D1R and D2R under similar experimental conditions. Trained rats showed a decr...

journal_title：Brain research

authors： Soiza-Reilly M,Fossati M,Ibarra GR,Azcurra JM

更新日期：2004-04-09 00:00:00

abstract：:Recent studies suggest that both sex and cerebral hemisphere influence brain mechanisms associated with emotional memory. Here we used evoked potentials to examine the influence of sex and hemisphere on brain responses to emotional stimuli. Given that the P300 component of the event-related brain potential (ERP) is co...

journal_title：Brain research

authors： Gasbarri A,Arnone B,Pompili A,Pacitti F,Pacitti C,Cahill L

更新日期：2007-03-23 00:00:00

abstract：:Infection and inflammation leading to injury or death of pre-oligodendrocytes (preOLs) is one of the principal initiating mechanisms in the pathogenesis of preterm periventricular leukomalacia (PVL). The present study explores the possible protective effect of curcumin against the toxicity of lipopolysaccharide (LPS)-...

journal_title：Brain research

authors： He LF,Chen HJ,Qian LH,Chen GY,Buzby JS

更新日期：2010-06-21 00:00:00

abstract：:The non-cholinergic slow excitatory postsynaptic potential (EPSP) in the guinea pig inferior mesenteric ganglion (IMG) is believed to be mediated by substance P (SP). Yet, in ganglia of guinea pigs treated with capsaicin (50, 100, or 350 mg/kg, s.c.), a compound that depletes SP from sensory neurons, slow EPSPs were o...

journal_title：Brain research

authors： Peters S,Kreulen DL

更新日期：1984-06-11 00:00:00

abstract：:gamma-L-Glutamyl-L-aspartic acid (gamma-LGLA) has been isolated from Datura stramonium; its structure has been determined and it was then synthesized. In male Swiss mice intraperitoneal administration of the natural peptide (125 nmol/kg) or of the synthetic peptide (25-2500 nmol/kg) 24 h after acquisition of a Y-maze ...

journal_title：Brain research

authors： Ungerer A,Schmitz-Bourgeois M,Mélan C,Boulanger Y,Reinbolt J,Amiri I,de Barry J

更新日期：1988-04-19 00:00:00

abstract：:The primary mechanism of action of bupropion, a smoking cessation drug, is commonly believed to involve the dopaminergic system although evidence exists that bupropion also has effects at nicotinic acetylcholine receptors (nAChRs). This study evaluated the disruptive effects of nicotine on response rates in the presen...

journal_title：Brain research

authors： Vann RE,Rosecrans JA,James JR,Philibin SD,Robinson SE

更新日期：2006-10-30 00:00:00

abstract：:It is now well documented that optogenetics brings to neuroscience a long sought-after foothold to study the causal role of millisecond-scale activity of genetically or anatomically defined populations of neurons. Progress is rapid, and, as evidenced by the work collected in this Special Issue, the possibilities of wh...

journal_title：Brain research

authors： Smith KS,Graybiel AM

更新日期：2013-05-20 00:00:00

abstract：:Slices of rat hippocampus were exposed to 700 MHz continuous wave radiofrequency (RF) fields (25.2-71.0 V m(-1), 5-15 min exposure) in a stripline waveguide. At low field intensities, the predominant effect on the electrically evoked field potential in CA1 was a potentiation of the amplitude of the population spike by...

journal_title：Brain research

authors： Tattersall JE,Scott IR,Wood SJ,Nettell JJ,Bevir MK,Wang Z,Somasiri NP,Chen X

更新日期：2001-06-15 00:00:00

abstract：:The effects of 17beta-estradiol (17betaE2) on spontaneous and excitatory amino acid (EAA) induced nucleus tractus solitarius (NTS) neuronal activity were investigated by electrophysiological and immunohistochemical experiments in ovariectomized female Sprague-Dawley rats. Out of 62 NTS neurons tested, 42 were inhibite...

journal_title：Brain research

authors： Xue B,Hay M

更新日期：2003-06-20 00:00:00

abstract：:Migraine headache is proposed to be mediated by nitric oxide (NO). Suitable mechanisms for eliciting increases in brain NO concentration in migraineurs have not yet been identified, although, animal models highlight cortical spreading depression (CSD) as a potential candidate. These studies have focused on CSD-associa...

journal_title：Brain research

authors： Read SJ,Hirst WD,Upton N,Parsons AA

更新日期：2001-02-09 00:00:00

abstract：:The effects of lesions in the pars compacta of the substantia nigra of 4-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were studied on (a) changes in blood pressure during a period of 6 weeks following lesioning, and (b) dopamine and metabolite concentrations in the caudate nu...

journal_title：Brain research

authors： Linthorst AC,van Giersbergen PL,Gras M,Versteeg DH,de Jong W

更新日期：1994-03-14 00:00:00

abstract：:This study investigated the effects of morphine microinjection into the nucleus raphe magnus (RMg) on electrically evoked C-fiber activities of convergent neurons in the spinal trigeminal nucleus oralis (Sp5O), in halothane-anesthetized rats. Although the neurons could be depressed by systemic morphine (6 mg/kg, i.v.)...

journal_title：Brain research

authors： Dualé C,Molat JL,Dallel R

更新日期：1998-08-24 00:00:00

abstract：:Monkeys can gradually increase or decrease the amplitude of the segmentally mediated spinal stretch reflex (SSR) without change in initial muscle length or background EMG activity. Both increase (under the SSR increases mode) and decrease (under the SSR decreases mode) occur slowly, progressing steadily over weeks. Th...

journal_title：Brain research

authors： Wolpaw JR

更新日期：1983-11-14 00:00:00