Abstract：
:The L-isomer of beta-N-methylamino-L-alanine (BMAA), present in free form in seed of Cycas circinalis, elicits in spinal cord cultures a pattern of acute postsynaptic neuronal vacuolation comparable to that induced by beta-N-oxalylamino-L-alanine (BOAA), an excitotoxic amino acid of greater potency isolated from seed of Lathyrus sativus. The neuronotoxic properties of these compounds may be linked to the etiology of motor-system degenerative disorders (amyotrophic lateral sclerosis and lathyrism, respectively) found in human groups that have used these plant seeds for food.
journal_name
Brain Resjournal_title
Brain researchauthors
Nunn PB,Seelig M,Zagoren JC,Spencer PSdoi
10.1016/0006-8993(87)90342-8subject
Has Abstractpub_date
1987-05-05 00:00:00pages
375-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90342-8journal_volume
410pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Reactive oxygen species (ROS) are supposed to be involved in neurodegenerative processes like Parkinson's or Alzheimer's disease. Beside this there are an increasing number of studies indicating an involvement of ROS in traumatic brain injury. We therefore studied the potential role of astrocytes against neurotoxic ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01029-3
更新日期：1996-12-16 00:00:00
abstract：:Wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to study transneuronal transport in the developing rat visual pathways. Intraocular injections of WGA-HRP were made in neonatal albino rat pups at different ages from the day of birth, postnatal day 0 (P0), to one month of age. Transneuronal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90087-9
更新日期：1988-01-01 00:00:00
abstract：:Glucocorticoids (GCs) predispose hippocampal neurons to damage during metabolic stressors. One component of hippocampal GC-endangerment may be changes in neuronal defenses against oxidative challenge. Previous experiments showed a decrease in basal levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and glutathione...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00104-8
更新日期：1998-04-27 00:00:00
abstract：:The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in cultu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90098-8
更新日期：1993-10-08 00:00:00
abstract：:Following infection with influenza virus, animals display decreased locomotor activity and feeding behavior and loss of body weight. It has been suggested that these effects may be mediated by cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-alpha), induced by the infe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01009-3
更新日期：1997-11-21 00:00:00
abstract：:Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive loss of cognitive function, dementia, and problems with movements. In order to find new protein biomarkers of high specificity from cerebrospinal fluid (CSF) of AD and PD patients, one-dimensiona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.058
更新日期：2009-04-10 00:00:00
abstract：:Acute noradrenergic stimulation has previously been shown to stimulate brain (Na+, K+)-adenosine triphosphatase activity. Effects of repeated stimulation with piperoxane were examined in the present study. Daily piperoxane increased ouabain binding, measured 24 h after the last dose, after 4 days or 3 weeks treatment;...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90258-4
更新日期：1981-06-01 00:00:00
abstract：:Hypoxia-inducible transcription factors (HIFs) are crucially involved in brain development and cellular adaptation to hypoxia and ischemia. Degradation of HIF is regulated under normoxia by oxygen-dependent hydroxylation of specific prolyl residues on the labile alpha-subunit by HIF prolyl hydroxylases (PHD). Prolyl-4...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.023
更新日期：2009-07-14 00:00:00
abstract：:Previous studies have demonstrated a higher mean peak frequency of the hippocampal (HPC) theta rhythm during REM sleep in alcohol-nonpreferring (NP) rats when compared with alcohol-preferring (P) rats. Burst firing neurons of the medial septal area (MS/VDB) are thought to pace the HPC theta rhythm during REM sleep and...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01520-5
更新日期：1996-04-01 00:00:00
abstract：:The present report summarizes the results obtained in previous experiments in which the responses to lateral tilt of both reticulocerebellar neurons located in the lateral reticular nucleus (NRL) and ascending spinoreticular tract axons, located in the lateral funiculi of the cervical segments C2-C3, had been recorded...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90112-2
更新日期：1975-09-23 00:00:00
abstract：:Gonadal steroids are thought to act by activation of the genome following cytoplasmic binding, translocation of the hormone--receptor complex to the nucleus and chromatin binding at specific acceptor sites. This study examined the kinetics of chromatin binding of estradiol by hypothalamic and cortical cells of adult g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90138-5
更新日期：1978-08-18 00:00:00
abstract：:Neurons immunoreactive for the calcium-binding protein calretinin (CR) were visualized in the substantia nigra (SN) pars compacta (SNc), reticulata (SNr) and lateralis (SNl), the ventral tegmental area (VTA) and the subthalamic nucleus (STN) of squirrel monkeys. The density of CR perikarya was high in VTA, moderate in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01374-1
更新日期：1996-02-05 00:00:00
abstract：:High molecular weight complexes of aminoacyl-tRNA synthetases isolated from rat brain catalyze the formation of glutamyl-tRNA with an initial lag time of the order of 1 min, as previously reported for the formation of glutamyl-tRNA and glutaminyl-tRNA catalyzed by similar complexes from bovine brain (Vadeboncoeur and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(86)90016-1
更新日期：1986-07-01 00:00:00
abstract：:Superfusion of rat hypothalamic slices with 10(-4) M N-methyl-D-aspartic acid (NMDA) resulted in increased release of alpha-melanocyte-stimulating hormone (alpha-MSH). Peptide release was blocked by 10(-6) M NG-nitro-L-arginine methyl ester (L-NAME) a specific competitive inhibitor of nitric oxide synthase but not by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90773-0
更新日期：1994-12-15 00:00:00
abstract：:Social plasticity is the ability to adaptively change the expression of social behaviour according to experience, allowing animals to optimize their social relationships in the context of previous experience and the complexities of social environments. Environmental enrichment (EE) mimics a stimulating lifestyle at th...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2019.03.033
更新日期：2019-08-15 00:00:00
abstract：:We examined the effect of long-term exposure to radio frequency radiation 147 MHz and its sub-harmonics 73.5 and 36.75 MHz amplitude modulated at 16 and 76 Hz (30-35 days, 3 h per day) on cholinergic systems in developing rat brain. A significant decrease in acetylcholine esterase activity was found in exposed rats as...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91729-c
更新日期：1993-01-22 00:00:00
abstract：:Methamphetamine is a highly addictive psychostimulant that has surged in popularity worldwide in the last decade. Brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is widely expressed in the adult mammalian brain and plays an important role in the long-term survival, differentiation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.053
更新日期：2010-10-21 00:00:00
abstract：:Tyrosine hydroxylase phenotype expression was investigated in the catecholaminergic population of the locus coeruleus neurons of two pure inbred mouse strains, Balb/C and C57Black/6. Therefore, we have characterized the precise organization of tyrosine hydroxylase-expressing perikarya population, in control animals an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00074-1
更新日期：1996-05-20 00:00:00
abstract：:The development of hypertension in spontaneously hypertensive rats (SHR) and hyperactive voiding in rats with urethral obstruction are characterized by abnormal smooth muscle growth, increased tissue levels of nerve growth factor (NGF) and altered patterns of innervation. The present study was undertaken to determine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00061-4
更新日期：1998-04-20 00:00:00
abstract：:Accumulating evidence indicates that neurite degeneration occurs via a distinct mechanism from somal death programs. We have previously shown that neuritic ATP level in sympathetic neurons decreases, whereas somal ATP level remains unaltered during degeneration caused by the microtubule-disrupting agent, vinblastine. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.050
更新日期：2004-12-24 00:00:00
abstract：:Accumulating evidence suggests that dopamine (DA) neurons in the ventral tegmental area (VTA) contribute to the complex amygdala-based neurocircuitry that mediates fear-motivated behaviors. Because of acetylcholine's (ACh) role in DA neuronal activation, the involvement of VTA cholinergic muscarinic receptors in Pavlo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02414-8
更新日期：2000-07-07 00:00:00
abstract：:The effects of cocaine administration and withdrawal on D1 and D2 dopamine receptor number, affinity, and mRNA levels were examined in rats trained to self-administer cocaine for four weeks on a continuous reinforcement schedule. Two hours after the last infusion of cocaine there was a decrease in the number and agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90255-0
更新日期：1994-01-14 00:00:00
abstract：:Malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) develop hypertension and stroke at earlier ages than do nonmalignant SHRSP. Our previous findings suggested that reactive oxygen species were involved in the development of stroke in this strain. Nitric oxide (NO) which is more released at ischemia, migh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02975-x
更新日期：2002-09-13 00:00:00
abstract：:The subfornical organ (SFO), a neuroendocrine structure implicated in saltwater homeostasis, contains secretory structures histochemically similar to those in the neurohypophysis. Because of these morphological similarities, we compared levels of vasopressin (vp) in the SFO area and the adjacent hippocampal commissure...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90458-4
更新日期：1978-01-27 00:00:00
abstract：:Immunohistochemical studies of a peroxisomal enzyme, bifunctional protein, were performed on human brains (occipital cortex, cerebellum, pons) from fetus to young adult. Bifunctional protein-positive neurons appeared at 23-25 weeks of gestation in the facial nuclei of pons, at 27-28 weeks in the occipital cortex and P...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91878-3
更新日期：1994-03-21 00:00:00
abstract：:Somatostatin (SRIF) receptors are expressed in the external granule cell layer of the rat cerebellum during early postnatal life. The aim of the present study was to investigate the distribution and biochemical characteristics of SRIF binding sites in the cerebellum of homozygous (vasopressin deficient) Brattleboro ra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91750-b
更新日期：1990-11-05 00:00:00
abstract：:Notch signaling is a highly conserved pathway that regulates cell fate decisions during embryonic development. We have recently identified that in ischemic stroke, activity of γ-secretase and the resulting Notch activation may endanger neurons by modulating NF-κB and HIF-1α pathways. Notch signaling can also modulate ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.054
更新日期：2014-10-24 00:00:00
abstract：:Horseradish peroxidase injections into the medulla of tadpoles demonstrate, by back-filling, efferent neurons in the torus semicircularis which project to the ipsilateral superior olive. This projection, as well as one to the vicinity of the efferent neurons of the contralateral VIII and lateral line nerves, is confir...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90774-1
更新日期：1984-02-06 00:00:00
abstract：:The purpose of this work was to characterize the gap junctions between cultured glomus cells of the rat carotid body and to assess the effects of acidity and accompanying changes in [Ca(2+)](i) on electric coupling. Dual voltage clamping of coupled glomus cells showed a mean macrojunctional conductance (G(j)) of 1.16 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02862-1
更新日期：2001-10-19 00:00:00
abstract：:The morphological and physiological identification of the cells in the inner retina of Japanese dace was made by means of intracellular single cell recording and dye injection techniques. Our flat mounts and physiological classification revealed that 97 out of 102 sample cells were amacrine cells except for 3 transien...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91140-6
更新日期：1986-05-07 00:00:00
