Abstract：
:3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine and epinephrine. DOPEGAL, but not other metabolites, kills differentiated PC-12 cells. However, the type of DOPEGAL induced cell death, whether necrosis or apoptosis, is not known. To determine the type of cell death triggered by DOPEGAL, PC-12 cells cultured in the presence or absence of 30 microM DOPEGAL were examined by electron microscopy and DNA agarose gel electrophoresis for characteristic features of apoptosis. Results indicate that DOPEGAL induces apoptosis in these cells. Implications for degenerative diseases are discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Burke WJ,Schmitt CA,Miller C,Li SWdoi
10.1016/s0006-8993(97)00447-2subject
Has Abstractpub_date
1997-06-20 00:00:00pages
290-3issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00447-2journal_volume
760pub_type
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