Abstract：
:5-HT2 receptor binding sites were measured (by saturation binding of [3H]ketanserin) in brain tissue obtained at postmortem from 19 suicide victims with definite evidence of depression and 19 sex and age-matched control subjects. Five of the suicide victims were receiving antidepressant drugs prior to death; 13 suicide victims had not been prescribed antidepressant or other psychoactive drugs recently and none were found in their blood at postmortem. The number of serotonin-2 (5-HT2) binding sites in frontal, temporal and occipital cortex and amygdala did not differ significantly between the depressed suicide victims and controls, either in the total suicide group or in the antidepressant drug-free suicides. The number of 5-HT2 binding sites in the hippocampus did not differ from controls in the total suicide group but was significantly lower (by 23%) in the antidepressant-free suicide group. The affinity of [3H]ketanserin binding did not differ from controls in the antidepressant-free suicides but was lower (increased Kd) in those subjects receiving antidepressant drugs. No correlation was found between the time of death and storage of tissue or the duration of tissue storage prior to assay and the number or affinity of 5-HT2 binding sites. A significant negative correlation was found between age of the subject and the number of 5-HT2 binding sites in the frontal and occipital cortex. The present study of suicide victims with definite evidence of depression do not confirm previous studies of increased numbers of 5-HT2 binding sites in suicide victims and suggest that these previous findings may be related to factors other than depression.
journal_name
Brain Resjournal_title
Brain researchauthors
Cheetham SC,Crompton MR,Katona CL,Horton RWdoi
10.1016/0006-8993(88)91621-6subject
Has Abstractpub_date
1988-03-08 00:00:00pages
272-80issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(88)91621-6journal_volume
443pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:To verify whether microtubules are involved in the mechanism of axoplasmic transport in vivo, [3H]leucine was injected into ventral horns of rats, and 3 h later Ca2+ or other drugs injected into sciatic nerves. The injection of 50-200 mM Ca2+, raising intra-axoplasmic Ca2+ levels, blocked transport above the intraneur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90514-7
更新日期：1986-03-26 00:00:00
abstract：:Picture-word interference is a widely employed paradigm to investigate lexical access in word production: Speakers name pictures while trying to ignore superimposed distractor words. The distractor can be congruent to the picture (pictured cat, word cat), categorically related (pictured cat, word dog), or unrelated (p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.050
更新日期：2012-04-23 00:00:00
abstract：:Met-enkephalin-like immunoreactivity in microdialysates from the respiratory-related nucleus tractus solitarii was determined simultaneously with ventilatory responses in seven, spontaneously breathing, developing swine under conditions of normoxia, hypoxia and recovery from hypoxia for 30 min each. Assayed levels of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00541-w
更新日期：1995-07-31 00:00:00
abstract：:Protein uptake and transport within the brain stem vasculature of mechanically brain injured cats was studied by means of both light and electron microscopy utilizing intravenously injected horseradish peroxidase as the protein tracer. In animals sustaining low grade head injuries not of sufficient intensity to elicit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90404-3
更新日期：1978-09-22 00:00:00
abstract：:Autoradiographic localization of binding sites for [3H]prostaglandin D2, E2 and F2 alpha in the monkey brain was investigated by using in vitro labeling and an image processing system. Specific binding sites were distinctly localized in various nuclei in the hypothalamus, thalamus, and limbic system and their localiza...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91486-8
更新日期：1989-01-23 00:00:00
abstract：:Electrical stimulation of the subfornical organ (SFO) in urethane anesthetized male Sprague-Dawley rats was associated with intensity and frequency dependent increases in arterial blood pressure. Stimulation in the hypothalamic paraventricular nucleus (PVN) also evoked increases in arterial blood pressure. Electrolyti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90443-8
更新日期：1984-07-09 00:00:00
abstract：:The effect of intraocular injection of the neurotoxin, kainic acid, on the retinofugal pathway has been examined by anterograde transport of horseradish peroxidase. Although less peroxidase was present in all the primary optic centers after the intraocular injection of kainic acid than in the controls, the area occupi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90939-9
更新日期：1984-01-09 00:00:00
abstract：:The role of histamine in mediating restraint stress-induced alterations in dopaminergic neuronal activity and alpha-melanocyte-stimulating hormone (alpha MSH) secretion was evaluated in male rats. Dopaminergic neuronal activity was estimated by measuring concentrations of the dopamine metabolite 3,4-dihydroxyphenylace...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90399-9
更新日期：1994-08-08 00:00:00
abstract：:Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01189-7
更新日期：1995-12-15 00:00:00
abstract：:Increasing evidence indicates that volatile general anesthetics exert their effects by affecting various types of membrane conductance expressed in the central nervous system (CNS), such as ligand-gated receptor-channels. The most recently identified family of the receptor-channels in the CNS are the extracellular ATP...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03125-0
更新日期：2001-12-07 00:00:00
abstract：:Field potentials preceding vocalization were recorded with electrodes chronically implanted on the surface and at 2.0-3.0 mm depth in various cortical areas in three monkeys. Surface-negative, depth-positive (s-N, d-P) slow potentials prior to vocalization were recorded in the premotor (including the Broca's homology)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00797-t
更新日期：1995-10-30 00:00:00
abstract：:Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tiss...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90488-9
更新日期：1986-04-09 00:00:00
abstract：:Extracellular recordings were conducted in the paraflocculus of anesthetized Long-Evans pigmented rats to determine how ionotophoresis of norepinephrine (NE) affects the responsiveness of individual Purkinje cells and interneurons to presentations of visual stimuli within their visual receptive fields. Presentations o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91421-c
更新日期：1990-04-30 00:00:00
abstract：:Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.036
更新日期：2010-03-12 00:00:00
abstract：:Concentrations of monoamines and metabolites and uric acid were measured in sequential 15-min microdialysis samples taken from the area of the supraoptic nucleus (SON) in 9 urethane-anaesthetized rats. A decrease in blood pressure of 40 mm Hg was induced by withdrawing 3-4 ml of blood from an indwelling jugular cathet...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91016-5
更新日期：1988-02-09 00:00:00
abstract：:Alzheimer's disease is a common age associated neurodegenerative disorder associated with an elevated risk of seizures that may be fundamentally connected to cognitive dysfunction. We used 4-9month-old mice of the APP/PS1 mouse model of Alzheimer's disease to study the presence of epileptiform-like discharges and to e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.09.026
更新日期：2017-12-15 00:00:00
abstract：:The effect of neuroprotective drugs on the early and late electrophysiological manifestations of photothrombotic occlusion of distal branches of middle cerebral artery was studied in rats treated with MK-801 and Cerebrolysin (CL). DC potentials were recorded from the irradiated cortex (ischemic core), from the adjacen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01448-0
更新日期：1998-03-09 00:00:00
abstract：:The N400 is an event-related potential (ERP) component that is elicited by semantically meaningful stimuli; one of its defining characteristics is that it is amplified for sentence completions that are semantically unexpected or incongruous with the preceding context. Some prior reports using visual sentence reading p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.099
更新日期：2010-10-08 00:00:00
abstract：:The link between the state of energy balance and reproductive function is well known. Thus, signals denoting negative energy balance and the accompanying hyperphagic drive are likely to be factors in the suppression of gonadotropin releasing hormone (GnRH) activity. We have previously found that appetite-regulating sy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.066
更新日期：2005-04-18 00:00:00
abstract：:Glycoprotein M6a is a neuronally expressed member of the proteolipid protein (PLP) family of tetraspans. In vitro studies suggested a potential role in neurite outgrowth and spine formation and previous investigations have identified M6a as a stress-regulated gene. To investigate whether the distribution of M6a correl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.11.066
更新日期：2008-03-04 00:00:00
abstract：:This study investigated the relationship between central cholinergic neurons and insulin secretion in bilateral adrenalectomized fed rats. Neostigmine (a cholinesterase inhibitor, 5 x 10(-8) mol) administered into the third cerebral ventricle produced significant increases in hepatic venous plasma insulin and glucose ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91003-2
更新日期：1989-07-24 00:00:00
abstract：:In order to investigate the interplay between visuo-spatial attention and central attention, we varied the relative probability (25% vs. 75%) of the responses to lateralized targets in an attentional blink paradigm. When the first target was associated with a less probable response, we observed a larger attentional bl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.004
更新日期：2007-12-14 00:00:00
abstract：:[d-Ala(2)-d-Leu(5)]-Enkephalin (DADLE) has shown promising results in protecting neurons from damages. However, the mechanism for this protection is still under investigation. The current study was carried out to test the hypothesis that DADLE may regulate cellular transcription in neurons. SH-SY5Y cells and primary c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.04.007
更新日期：2014-05-27 00:00:00
abstract：:Previous studies resulted in conflicting conclusions that glutamate application either decreases or increases the activity of Ca2+ channels in hippocampal neurons. We studied whole-cell Ca2+ currents (ICa) in chick dorsal root ganglion neurons and rat hippocampal cells. For both cell types glutamate (1-30 microM) incr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90965-c
更新日期：1992-05-15 00:00:00
abstract：:Wayfinding is a complex cognitive function involving different types of information, such as knowledge about landmarks and direction information. This variety of processes suggest that multiple neural mechanisms are involved, e.g., the hippocampal system, the posterior parietal and temporal cortical areas. Although pa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.048
更新日期：2006-01-05 00:00:00
abstract：:Recordings were made from single neurons in the rat's central nucleus of the inferior colliculus (ICc). Binaural responses were studied when dichotic tone bursts with various interaural-level differences were presented simultaneously or with a contralateral delay. These dichotic tone bursts allowed us to probe tempora...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.059
更新日期：2009-12-15 00:00:00
abstract：:The localization of the glycine cleavage system was examined in the rat brain by immunohistochemistry using an antibody to P-protein (a constituent of the system). In all sites studied, the enzyme was confined to the astrocytes. The intensity of astrocyte staining varied in different brain regions, with the strongest ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91436-5
更新日期：1991-12-13 00:00:00
abstract：:Cannabinoids are promising therapies to support neurogenesis and decelerate disease progression in neuroinflammatory and degenerative disorders. Whether neuroprotective effects of cannabinoids are sustainable during persistent viral infection of the CNS is not known. Using a rodent model of chronic viral encephalitis ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.08.032
更新日期：2013-11-06 00:00:00
abstract：:Numerous studies with PC12 cells have suggested that the mitogen-activated protein (MAP) kinase pathway might play a major role in the neuronal differentiation that is induced by nerve growth factor (NGF). Cells of the PC12D subline extend neurites within several hours in response to NGF in the presence of inhibitors ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01403-0
更新日期：1998-03-02 00:00:00
abstract：:Early brain injury (EBI) plays a pivotal role in the prognosis of patients with subarachnoid haemorrhage (SAH). Dexmedetomidine (DEX), a highly selective α2 receptor agonist, is reported to exert multiple protective effects in many neurological diseases. This study was designed to investigate whether DEX had neuroprot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.05.040
更新日期：2018-11-01 00:00:00
