Abstract：
:Previous studies resulted in conflicting conclusions that glutamate application either decreases or increases the activity of Ca2+ channels in hippocampal neurons. We studied whole-cell Ca2+ currents (ICa) in chick dorsal root ganglion neurons and rat hippocampal cells. For both cell types glutamate (1-30 microM) increased high-threshold Ca2+ current. It was independent of the charge carriers, Ca2+ or Ba2+. Low-threshold Ca2+ channel current and the fast sodium current were not changed with glutamate application. The effect developed within 1-2 min and then further facilitated after washout of the agonist. A second application of glutamate produced no additional increase in ICa. No changes in the time-course of whole-cell currents were observed, suggesting that glutamate recruits 'sleepy' Ca2+ channels. Whatever its mechanism, overlasting increase of ICa by glutamate may be important in neuronal plasticity.
journal_name
Brain Resjournal_title
Brain researchauthors
Mironov SL,Lux HDdoi
10.1016/0006-8993(92)90965-csubject
Has Abstractpub_date
1992-05-15 00:00:00pages
341-4issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90965-Cjournal_volume
580pub_type
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