Abstract：
:Dopaminergic neurotoxicities of 6-hydroxydopamine (6-OHDA) and the lipopolysaccharide (LPS) were compared in rat mesencephalic cultures plated on poly-L-lysine or on glial monolayers. In the neuron-enriched cultures plated on polylysine, 6-OHDA killed 89% of the tyrosine hydroxylase (TH)-immunopositive neurons, but LPS was not neurotoxic. Conversely, in mixed neuron/glial cultures, 6-OHDA killed only 27% of the TH-immunopositive neurons while LPS killed 70%. The mixed neuronal/glial mesencephalic culture offers a better in vitro model for studying possible mechanisms involved in Parkinson's disease.
journal_name
Brain Resjournal_title
Brain researchauthors
Bronstein DM,Perez-Otano I,Sun V,Mullis Sawin SB,Chan J,Wu GC,Hudson PM,Kong LY,Hong JS,McMillian MKdoi
10.1016/0006-8993(95)01189-7subject
Has Abstractpub_date
1995-12-15 00:00:00pages
112-6issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(95)01189-7journal_volume
704pub_type
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