Abstract：
:Relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a neurotoxin selective for catecholaminergic neurons. Since calcium binding proteins are reported to provide neuroprotective influence in neurons, differences in the distribution of the calcium binding proteins might be related to the different vulnerabilities of dopaminergic neurons and axons to neurotoxins. To address this possibility, we characterized patches of relatively dense tyrosine hydroxylase-immunoreactive (TH-IR) axons in intrastriatal 6-OHDA lesioned rats, focusing on two calcium binding proteins, calbindin (CB) and calretinin (CR). The patches and subcallosal layer of preserved dopaminergic axons in the striatum of rats lesioned with 6-OHDA contained CR, a 31-kDa calcium-binding protein, but interestingly not CB. Dopaminergic neurons containing CR in the substantia nigra pars compacta (SNpc) were relatively spared compared to those that did not contain CR. Taken together, our data indicate that dopaminergic axons and neurons containing CR in the nigrostriatal pathway are more resistant to 6-OHDA lesion than those that do not contain CR.
journal_name
Brain Resjournal_title
Brain researchauthors
Tsuboi K,Kimber TA,Shults CWdoi
10.1016/s0006-8993(00)02219-8subject
Has Abstractpub_date
2000-06-02 00:00:00pages
55-64issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02219-8journal_volume
866pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:A Rous Sarcoma virus transformed cerebellar cell line, BC6, secretes a factor which causes clonal glial cell lines to rapidly (1 h) extend processes. The factor shows a degree of specificity since only 3 out of 10 lines which exhibit either glial or combined glial and neuronal properties respond. The active factor app...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90214-6
更新日期：1983-12-01 00:00:00
abstract：:Glial-derived monocarboxylate lactate is thought to be an important energy source for neurons during brain activation or in hypoxia-ischemia. Treatment with alpha-cyano-4-hydroxycinnamate (4-CIN), a monocarboxylate transporter inhibitor, has been recently reported to exacerbate delayed neuronal damage in a rat model o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03375-4
更新日期：2003-10-31 00:00:00
abstract：:The double-labeling, fluorescent dye technique was used in order to demonstrate the extent to which the central processes of renal afferent neurons directly project to the brainstem. One injection of a fluorescent dye was placed in the cortex of the left kidney of male rats, and a second injection of a different dye w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91154-5
更新日期：1984-04-23 00:00:00
abstract：:The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the basolateral amygdala were measured by in vivo microdialysis. Inescapable, but not escapable, shock increased extracellular 5-HT in the amygdala relative to restrained controls. Basal levels of 5-HT wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00960-3
更新日期：1998-11-23 00:00:00
abstract：:Projections to the rostral ventrolateral medulla (RVLM) and nucleus raphe magnus (NRM) appear to originate from neurones with overlapping distributions in the periaqueductal grey (PAG) as demonstrated by the retrograde transport of red and green fluorescent latex microspheres. Furthermore, double-labelling studies dem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00784-6
更新日期：1996-09-09 00:00:00
abstract：:Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of ac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.11.028
更新日期：2017-02-15 00:00:00
abstract：:Inbred mouse strains differed significantly in sensitivity to convulsions induced by 9 convulsant drugs administered using a timed infusion procedure. Some strains (e.g. BALB/cJ, A/J) were generally seizure-susceptible, while some were generally seizure resistant (e.g. C57BL/6J, SWR/J). However, the overall pattern of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90243-5
更新日期：1990-08-27 00:00:00
abstract：:Cholinergic mechanisms in the septohippocampal pathway contribute to several cognitive functions and impaired cholinergic transmission in this pathway may be related to the memory loss and dementia that accompanies normal aging and Alzheimer's disease and behavioral studies suggest that muscarinic mechanisms in the me...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00729-x
更新日期：1998-09-14 00:00:00
abstract：:Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01590-5
更新日期：1999-07-24 00:00:00
abstract：:In our previous study, we have found that leucine-rich repeats and immunoglobulin-like domains 1(LRIG1) can improve the chemosensitivity in U251 cells whereas the role of LRIG1 in multidrug resistance (MDR) remains unknown. Here, we reported that LRIG1 can reverse MDR by inhibiting epidermal growth factor (EGF) recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.023
更新日期：2015-06-22 00:00:00
abstract：:Astrocytes cultured from the brains of neonatal rat pups acquire at least two specializations of intramembrane particle distribution: 'assemblies' and gap junctions. The number and appearance of assemblies in the cultured astrocytes is not markedly influenced by the presence or absence of a collagen substrate, and the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90545-0
更新日期：1983-10-03 00:00:00
abstract：:The dopamine-releasing and depleting substance amphetamine (AMPH) can make cortical neurons susceptible to damage, and the prevention of hyperthermia, seizures and stroke is thought to block these effects. Here we report a 2-day AMPH treatment paradigm which affected only interneurons in three cortical regions with av...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03439-x
更新日期：2002-12-20 00:00:00
abstract：:In the brain, the neuropeptide cholecystokinin (CCK) appears to be involved in the mediation of stress responses. Here we provide new evidence that mild stress induces long-term changes in CCK-like immunoreactivity (CCK-LI) in the prefrontal cortex (PFC). The changes in CCK-LI show a biphasic pattern, with a decrease ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02648-8
更新日期：2001-07-27 00:00:00
abstract：:Transcranial magnetic stimulation (TMS) of human lower limb motor cortex paired with common peroneal nerve electrical stimulation produces a lasting modulation of motor cortex excitability following the principles of spike-timing-dependent plasticity. We previously demonstrated that this "paired associative stimulatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.03.062
更新日期：2007-06-11 00:00:00
abstract：:Recent work in our laboratory has demonstrated that spontaneous or evoked climbing fiber inputs are associated with an increased responsiveness of Purkinje cells to mossy fiber inputs activated by natural peripheral stimuli. These experiments were designed to test the hypothesis that this increased responsiveness occu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91027-8
更新日期：1984-08-20 00:00:00
abstract：:Schaffer collaterals of rat and mouse hippocampal slices were stimulated with bursts of pulses (300 Hz for 50 ms, 2-s intervals) for 30-s which caused a stable increase in the size of the population spike known as long-term potentiation. The release of adenosine triphosphate (ATP) was measured with a luciferase-lucife...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90567-2
更新日期：1989-04-24 00:00:00
abstract：:Release of Ca(2+) from intracellular Ca(2+) stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca(2+) source for the increased susceptibility to long-term depression (LTD) with advanced age is unknown. Extracellular excitatory postsynaptic field potent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.10.023
更新日期：2005-01-07 00:00:00
abstract：:The effects of continuous clonidine infusion (10 micrograms/kg/h for 10 days) and the cessation of this infusion on the circadian body temperature rhythm of the spontaneously hypertensive (SH) rat were examined. This circadian rhythm was blunted significantly during the infusion of clonidine. The fall in body temperat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91088-7
更新日期：1986-10-22 00:00:00
abstract：:The aim of this study was to describe the normal distribution of the water content in several regions of the rat brain and furthermore to determine if global ischemia results in a variable increase in water content in these regions. Water content was determined in 40 regions; in 8 unaffected brains by gravimetry and i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01165-1
更新日期：1997-02-21 00:00:00
abstract：:Two distinct patterns of terminal labeling were seen after injections of [3H]amino acids into the second somatosensory area (S2) and the retroinsular area (Ri). The first pattern, seen both in S2 after an injection in Ri and in the granular or dysgranular insular fields after an injection in S2, is characterized by he...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91103-4
更新日期：1983-08-22 00:00:00
abstract：:We examined the effect of long-term exposure to radio frequency radiation 147 MHz and its sub-harmonics 73.5 and 36.75 MHz amplitude modulated at 16 and 76 Hz (30-35 days, 3 h per day) on cholinergic systems in developing rat brain. A significant decrease in acetylcholine esterase activity was found in exposed rats as...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91729-c
更新日期：1993-01-22 00:00:00
abstract：:Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y1 receptor agonist [Leu31, Pro34]NPY (10 pmol) and Y2 agonist NPY13-36 (100 pmol) were administered unilaterally into the region of the nucleus locus coeruleus (LC) in rats. NPY (10 pmol) and NPY13-36 increased the percentage of open arm entries, the percentage of time spent o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00076-6
更新日期：1998-03-30 00:00:00
abstract：:In previous studies on Alzheimer's patients it was shown that, in frontal and parietal locations, delta and theta responses of AD patients were greatly reduced. The present study analyzed coherence functions in these highly affected frontal and parietal areas. Visual sensory and event related coherences of patients wi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.08.054
更新日期：2010-10-21 00:00:00
abstract：:We have previously demonstrated resiniferatoxin (RTX) to be an ultrapotent analog of capsaicin. Like capsaicin, RTX initially induces neurogenic inflammation, pain, and hypothermia and then causes desensitization of these responses. We examine here the duration of desensitization following acute treatment with the max...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91705-8
更新日期：1989-11-27 00:00:00
abstract：:Activities of individual, force-sensitive mechanoreceptors (funnel canal organs) of the terminal segment (dactyl) of the crab leg have been recorded in freely moving animals. During the stance phase of walking receptors discharge in regular bursts that are closely correlated with activity of the opener muscle of the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90663-8
更新日期：1985-06-17 00:00:00
abstract：:Aromatization of testosterone in the preoptic area of the male ring dove is required for the expression of specific estrogen-sensitive sexual behavior. Estradiol metabolism and/or binding of the aromatization product(s) to the preoptic estrogen receptors (ER) could interfere with the apparent increase in estradiol for...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90203-5
更新日期：1989-02-20 00:00:00
abstract：:Averaged evoked potentials and unitary discharges in response to tooth pulp and acoustic click stimuli were recorded from the hippocampus of freely moving rats. The spatial distribution of evoked field responses to tooth pulp stimulation and acoustic clicks were identical. Averaged evoked potentials consisted of a lar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90933-9
更新日期：1986-07-23 00:00:00
abstract：:The effects of clonidine (CLO) and phentolamine (PHE) on the sleep-waking cycle in the cat treated with alpha-methyl-p-tyrosine (AMPT) were investigated with continuous 16--24 h polygraphic recordings. For the evaluation of possible cholinergic interactions in the paradoxical sleep (PS) increasing effect of AMPT, an a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90949-x
更新日期：1980-07-07 00:00:00
abstract：:In freely-moving rats treated with a combination of reserpine (10 mg/kg, i.p.) and scopolamine (5 mg/kg, i.p.), neocortical low voltage fast activity (LVFA) associated with continuous multiunit activity (MUA) was abolished and replaced by 2-6 Hz large irregular slow activity (LISA) above 1.5 mV associated with a burst...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00396-4
更新日期：1996-07-29 00:00:00
abstract：:The distribution of calcitonin gene-related peptide (CGRP) and its binding sites in the bulbocavernosus, a striated muscle, are reported. We used immunohistochemistry and [125I]CGRP autoradiography. The pattern of [125I]CGRP binding was restricted to a discrete band that coincides with the distribution of end-plates i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91064-0
更新日期：1989-09-04 00:00:00
