Abstract:
:The effects of clonidine (CLO) and phentolamine (PHE) on the sleep-waking cycle in the cat treated with alpha-methyl-p-tyrosine (AMPT) were investigated with continuous 16--24 h polygraphic recordings. For the evaluation of possible cholinergic interactions in the paradoxical sleep (PS) increasing effect of AMPT, an atropine pretreatment was given to a group of cats receiving AMPT. Results were compared with those from previous experiments with PHE and atropine. When given alone, AMPT (150 mg/kg) decreased waking and increased deep slow wave sleep. Consistent with other reports PS was enhanced. These results support the hypothesis that moderate inhibition of catecholaminergic transmission favors the execution of PS in the cat. Previous studies have shown that CLO inhibits and PHE increases PS in the cat. In the present study administration of AMPT (150 mg/kg) did not alter the effect of CLO (0.01 mg/kg) or PHE (20 mg/kg) on PS; if anything, a slight potentiation was observed. These results support the view that stimulation of alpha 2-adrenoceptors is of major importance in the effect of CLO on PS and that in certain situations blockade of these receptors by PHE may contribute to its PS increasing action. The increase in PS induced by AMPT was moderate when compared with PS increase after injection of PHE (20 mg/kg) which enhances significantly both the number of PS episodes and their mean length. Atropine at a small dose of 0.075 mg/kg reverses the effect of PHE on PS, whereas it did not affect the sleep pattern induced by AMPT.
journal_name
Brain Resjournal_title
Brain researchauthors
Leppävuori Adoi
10.1016/0006-8993(80)90949-xsubject
Has Abstractpub_date
1980-07-07 00:00:00pages
117-28issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(80)90949-Xjournal_volume
193pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02400-8
更新日期:2000-07-07 00:00:00
abstract::Status epilepticus is a life-threatening form of seizure activity that represents a major medical emergency associated with significant morbidity and mortality. Protein Kinase A is an important regulator of synaptic strength that may play an important role in the development of status epilepticus-induced neuronal path...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.05.066
更新日期:2009-08-04 00:00:00
abstract:PURPOSE:To determine whether antisense oligonucleotides (AODNs) targeted against CRX, a photoreceptor-specific trans-acting factor, suppress CRX expression and interphotoreceptor retinoid binding protein (IRBP) promoter activity. METHODS:Cultures of human retinoblastoma cells were transfected with chloramphenicol acet...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02884-0
更新日期:2001-10-19 00:00:00
abstract::The effects of escapable and yoked inescapable electric tailshocks on extracellular levels of serotonin (5-HT) in the ventral hippocampus and dorsal periaqueductal gray (dPAG) were measured by in vivo microdialysis. Inescapable, but not escapable shock increased extracellular 5-HT in the ventral hippocampus relative t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00368-0
更新日期:1998-06-22 00:00:00
abstract::Infection and inflammation leading to injury or death of pre-oligodendrocytes (preOLs) is one of the principal initiating mechanisms in the pathogenesis of preterm periventricular leukomalacia (PVL). The present study explores the possible protective effect of curcumin against the toxicity of lipopolysaccharide (LPS)-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.04.014
更新日期:2010-06-21 00:00:00
abstract::This study determined baroreceptor reflex (BR) function in conscious rats which had received sham or electrolytic lesions of the anteroventral third ventricle (AV3V) 54-56 days previously. Resting mean arterial pressure (MAP) and heart rate (HR) values of the AV3V-lesion rats were similar to those of sham-lesion rats ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01561-9
更新日期:1999-07-24 00:00:00
abstract::In urethane-anesthetized rats, high frequency stimulation was applied to the medial perforant pathway at various time intervals (50, 100, 200, 350 and 500 ms) following stimulation of the same pathway by a single pulse of equal intensity. Recordings of dentate gyrus granule cell evoked responses were made to investiga...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91358-3
更新日期:1988-01-12 00:00:00
abstract:BACKGROUND:Previous experimental work using in situ zymography has shown very early increased plasminogen activation in ischemic regions after 3 h of ischemia with and without reperfusion. The objective of the present study was to evaluate the time course and extent of plasminogen activation in long-term permanent foca...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02769-4
更新日期:2000-11-03 00:00:00
abstract::Somatotopic projections of each maxillary molar tooth were defined by injecting individual teeth with True blue and plotting the location of fluorescent cells in sections of the trigeminal ganglia. Collateral branching was investigated by injecting True blue and Diamidino yellow into pairs of maxillary molar teeth and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90409-5
更新日期:1990-02-05 00:00:00
abstract::Enkephalin-like immunoreactive nerve fibers in the celiac ganglion of guinea pigs were characterized by a high population of large granular vesicles mixed with small clear vesicles. The immunoreactive material is confined to the large granular vesicles. The immunoreactive nerve fibers formed many axo-dendritic as well...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90987-8
更新日期:1982-12-02 00:00:00
abstract::Williams Syndrome (WS) is a neurodevelopment disorder associated with a hemizygous deletion on chromosome 7. WS is characterized with mental retardation, severe visual-spatial deficits, relative language preservation, and excellent facial recognition. Distinctive auditory features include musical ability, heightened s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.11.038
更新日期:2005-03-10 00:00:00
abstract::Electrophysiological recordings in rat brain slices have been used to study the actions of adenosine on striatal neurons and striatal excitatory amino acid neurotransmission originating in the cortex or the thalamus. Adenosine had no effects on membrane properties of striatal neurons. Adenosine and the A1 agonist N6-C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01060-3
更新日期:1997-12-05 00:00:00
abstract::Electrical stimulation of the mesencephalic locomotor region (MLR) in the precollicular-postmammillary transected cat is known to induce controlled locomotion on a treadmill. We have been able to induce and block locomotion in this preparation by using localized infusions of transmitters and their agonists and antagon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90006-x
更新日期:1985-03-18 00:00:00
abstract::The recent development of rodent models of bone cancer pain has started to provide the basis for demonstrating the particular neurochemical and behavioral entity of cancer pain. Behaviourally, both spontaneous pain and hyperalgesia related to mechanical, but not thermal, noxious stimuli have been described in cancer-b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02284-4
更新日期:2003-04-18 00:00:00
abstract::This EEG study (N=33) examined event-related potentials associated with conflict between activated responses in the Stroop task, in order to examine the conflict monitoring theory of cognitive control, which predicts the strength of exerted control to be proportional to the detected level of conflict. However, existin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.08.041
更新日期:2016-11-01 00:00:00
abstract::A search for vasomotor depressor sites in the lateral medullary brainstem of anesthetized cat using microinjections of AMPA has delineated a longitudinal column of sympathoinhibitory neurons consisting of the rostral depressor area, the caudal ventrolateral medulla, and a new intermediate depressor area. Systematic bl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91257-s
更新日期:1993-02-19 00:00:00
abstract::A potential mechanism for valproate (VPA)-induced increases in glial cell-substratum adhesivity has been demonstrated. Metabolically labelled glioma (C6) and primary astrocytes showed a statistically significant accumulation of protein when cultured in the presence of therapeutic concentrations of VPA (1 mM). This was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90292-2
更新日期:1988-08-30 00:00:00
abstract::1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was used to lesion the substantia nigra of rodents to look for changes in various animal models of epilepsy and seizures. MPTP, acutely administered to C57BL/6J mice, could cause seizures at high doses and enhanced maximal electroshock seizures at lower doses. Older ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91370-x
更新日期:1989-12-18 00:00:00
abstract::Continuing from earlier work which demonstrated the peripheral axonal regulation of Schwann cell myelination, this study has investigated the possibility that a peripheral axon can stimulate oligodendrocyte myelination. To test this hypothesis, regenerating PNS axons were allowed to interact with uncommitted oligodend...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90289-0
更新日期:1979-02-23 00:00:00
abstract::The density of binding sites for excitatory amino acids in the hippocampus of SDAT (senile dementia of the Alzheimer type) patients has been investigated. This was compared to that found in younger and old non-dement cases. In the SDAT hippocampi there was a significant decrease in the glutamate and kainate binding. T...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90706-8
更新日期:1988-08-09 00:00:00
abstract::The discontinuous terminal distributions of thalamo- and nigrostriatal axons were examined in adjacent tissue sections from single cat brains by combined anterograde labeling with tritiated proline autoradiography and wheat germ-horseradish peroxidase histochemistry. Injection of one tracer into the centromedian-paraf...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90287-2
更新日期:1985-05-27 00:00:00
abstract::This study investigates the effects of levetiracetam (LEV) on the functional and structural properties of blood-brain barrier (BBB) in pentylenetetrazole (PTZ)-kindled rats with cortical dysplasia (CD). Pregnant rats were exposed to 145 cGy of gamma-irradiation on embryonic day 17. In offsprings, kindling was induced ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.05.033
更新日期:2009-07-24 00:00:00
abstract::The role of the lateral parabrachial area (lPB) in the acquisition of a delayed taste aversion learning task (TAL) was examined by delivering the peripherally acting aversive compound, methylscopolamine (MSP), through two different routes, intraperitoneal and intraventricular. Consistent with previous anatomical, beha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02453-7
更新日期:2000-07-14 00:00:00
abstract::In the adult central nervous system (CNS), GABA and glycine (Gly) are predominant inhibitory neurotransmitters, negatively regulating glutamatergic transmission. In the immature CNS, on the other hand, they act as trophic factors, mediating morphogenesis. In the present study, to investigate their involvement in axona...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.01.048
更新日期:2012-03-29 00:00:00
abstract::Following the administration of horseradish peroxidase (HRP) in the middle or lower cervical cord segments of neonatal (1-10 days), developing (15-20 days) and mature (2-4 months) albino rats, labeled pyramidal neurons were found in layer V of the cerebral cortex. They formed one continuous band of labeled neurons in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91327-6
更新日期:1983-04-11 00:00:00
abstract::Visual-spatial working memory tasks can be decomposed into encoding and retrieval phases. It was hypothesized that encoding of visual-spatial information is cognitively more challenging than retrieval. This was tested by combining electroencephalography with a virtual reality paradigm to observe the modulation in EEG ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.05.086
更新日期:2010-08-06 00:00:00
abstract::Infusions of angiotensin II (AII) or carbachol (CBC) into the lateral ventricles of rats which had been depleted of sodium 4 h previously with either furosemide or polyethylene glycol produced significant changes in salt appetite and sodium and water balances relative to rats infused with saline vehicle. Infusions of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90860-1
更新日期:1985-11-04 00:00:00
abstract::In albino rats the superior colliculus was stimulated and evoked potentials were explored in the cerebellar hemisphere including the paramedian lobule, and crura I and II. Climbing fiber responses were identified in a strip (ca. 1 mm wide) in the medial region of crus II, extending to both folia a and b. In the tector...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90304-5
更新日期:1986-07-16 00:00:00
abstract::Using the monoclonal antibody G2-09 raised against bovine glia maturation factor (GMF), we demonstrated that cultured rat Schwann cells and Schwannoma cells, but not their conditioned media, possessed endogenous GMF-like immunoreactivity. The presence of immunoreactive GMF correlated well with GMF bioactivity. The GMF...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90140-x
更新日期:1988-05-16 00:00:00
abstract::We have explored the potential neuroprotective effect of local lentiviraly-mediated overexpression of nerve growth factor (NGF) on in vivo long-term potentiation (LTP) in the rat hippocampus under pathological conditions. The suspension of lentiviral particles was prepared using a genetic construct containing the huma...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.07.051
更新日期:2015-10-22 00:00:00