Abstract:
:Neuropeptide Y (NPY, 1 and 10 pmol), NPY Y1 receptor agonist [Leu31, Pro34]NPY (10 pmol) and Y2 agonist NPY13-36 (100 pmol) were administered unilaterally into the region of the nucleus locus coeruleus (LC) in rats. NPY (10 pmol) and NPY13-36 increased the percentage of open arm entries, the percentage of time spent on open part, number of both open and closed arm entries and line crossings in the open part while [Leu31,Pro34]NPY failed to modify elevated plus-maze behavior. These data suggest that NPY applied close to LC has anxiolytic-like effects by acting on NPY Y2, not on Y1 receptors. Thus, NPY Y2 receptors in the vicinity of LC may be involved in the regulation of anxiety in rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Kask A,Rägo L,Harro Jdoi
10.1016/s0006-8993(98)00076-6subject
Has Abstractpub_date
1998-03-30 00:00:00pages
345-8issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00076-6journal_volume
788pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::An in vitro preparation was used to determine if rapidly transported radiolabeled protein which is isolated with the myelin fraction of frog sciatic nerves is similar to rapidly transported radiolabeled protein released from sciatic nerves. Sciatic nerves along with their eighth and ninth dorsal root ganglia were plac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90525-x
更新日期:1982-05-13 00:00:00
abstract::Anesthetized Sprague-Dawley rats fitted with intracerebroventricular (i.c.v.) cannulas were infused with one of the aminopeptidase inhibitors, amastatin or bestatin, over a 5-min period. After infusion, 1-2 X 10(6) cpm of [125I]angiotensin II ([125I]AII) or [125I]angiotensin III ([125I]AIII) was injected through the s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91279-6
更新日期:1988-05-17 00:00:00
abstract::Perinatal asphyxia to the developing brain remains a major cause of morbidity. Hypothermia is currently the only established neuroprotective treatment available for term born infants with hypoxic-ischemic encephalopathy, saving one in seven to eight infants from developing severe neurological deficits. Therefore, addi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.05.040
更新日期:2016-09-01 00:00:00
abstract::Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91422-2
更新日期:1985-12-16 00:00:00
abstract::Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) is a potent neuroexcitatory compound which acts at the quisqualate class of excitatory amino acid receptors. In this study we describe the pharmacological characteristics and anatomical distribution of [3H]AMPA binding sites in rat brain using quantitativ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90636-x
更新日期:1984-12-17 00:00:00
abstract::We previously showed indirectly that the increase in diacylglycerol (DAG) levels caused by exposing differentiating PC12 cells to nerve growth factor (NGF) must derive mainly from de novo synthesis and, to a lesser and transient extent, from the hydrolysis of [3H]phosphatidylinositol (PI). To explore further the bioch...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)01280-3
更新日期:1999-02-13 00:00:00
abstract::We previously reported a model of acute cochlear energy failure using a mitochondrial toxin, 3-nitropropionic acid (3-NP), to study mechanisms of inner ear disorders such as inner ear ischemia. In this model, the main cause of hearing loss is apoptosis of fibrocytes in the cochlear lateral wall. Here, we analyzed the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.08.062
更新日期:2011-10-24 00:00:00
abstract::Rats exposed to stressors that cannot be controlled may develop a deficit in their ability to subsequently learn to control a new stressor. This phenomenon is known as 'learned helplessness' and is a well-accepted animal model of depression. Evidence is presented showing that rats having different directional biases o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91335-x
更新日期:1991-06-07 00:00:00
abstract::Brain/kidney (B/K) protein is a new protein of 474 amino acids, which contains two C2 domains structurally homologous to those present in synaptotagmins. The expression of B/K protein was identified in the rat retina and B/K protein immunoreactivity was localized to a number of ganglion cells, a few amacrine cells and...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02014-x
更新日期:2000-03-31 00:00:00
abstract::Glucocorticoids bind with high affinity to intracellular receptors located in high density within discrete regions of the rodent and primate brain. The binding of [3H]corticosterone was compared in the brains of male vs female rats. The number and affinity of cytosol receptors in the hippocampus and hypothalamus were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91153-9
更新日期:1985-09-16 00:00:00
abstract::The effect of stimulating the dorsal raphe nucleus (DRN) on the activity of single relay neurons in the dorsal lateral geniculate nucleus (LGNd) was studied in rats anesthetized with urethane. The position of stimulating electrodes was confirmed on histological sections processed with NADPH-diaphorase histochemistry w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90002-4
更新日期:1989-06-05 00:00:00
abstract::Attempts were made to determine the cells of origin of the spinal projections to the PAG using retrograde axoplasmic transport techniques of HRP and fluorescent markers. Following injections limited to the lateroventral subnucleus of the PAG, labels were transported to the contralateral laminae I, III, V, VII and X pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91127-7
更新日期:1983-03-28 00:00:00
abstract::Release of Ca(2+) from intracellular Ca(2+) stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca(2+) source for the increased susceptibility to long-term depression (LTD) with advanced age is unknown. Extracellular excitatory postsynaptic field potent...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.10.023
更新日期:2005-01-07 00:00:00
abstract::The coupling of muscarinic-cholinergic receptors (mAChR) to adenylate cyclase and phospholipase C (PLC) second messenger systems has been demonstrated in many animal species. However, little is known about this association in the developing human central nervous system. Because of the proposed role of acetylcholine in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90365-4
更新日期:1994-08-08 00:00:00
abstract::In over half a century numerous studies have demonstrated that different odorants produce individually different spatial patterns of neural receptor activity on the olfactory mucosa. However, the thought that these differential activity patterns could be the neural code underlying olfactory perception has not been tes...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02512-5
更新日期:2003-08-15 00:00:00
abstract::Field potentials preceding vocalization were recorded with electrodes chronically implanted on the surface and at 2.0-3.0 mm depth in various cortical areas in three monkeys. Surface-negative, depth-positive (s-N, d-P) slow potentials prior to vocalization were recorded in the premotor (including the Broca's homology)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00797-t
更新日期:1995-10-30 00:00:00
abstract::The effects of acute ethanol exposure of chick spinal cord neurons were studied in tissue culture, using whole-cell voltage-clamp techniques. Results indicate that ethanol produces a persistent increase in the sensitivity of spinal neurons to GABA and glycine, with no change in input resistance or resting membrane pot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90098-4
更新日期:1988-07-12 00:00:00
abstract::Fascia dentata tissue from embryonic mice was grafted to the hippocampal region of newborn Kyoto rats. After 1-7 months the recipients received lesions of the entorhinal cortex on the side of transplantation. Three days later their brains were processed for electron microscopy. The xenografts were identified by their ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91036-5
更新日期:1987-06-16 00:00:00
abstract::Schaffer collaterals of rat and mouse hippocampal slices were stimulated with bursts of pulses (300 Hz for 50 ms, 2-s intervals) for 30-s which caused a stable increase in the size of the population spike known as long-term potentiation. The release of adenosine triphosphate (ATP) was measured with a luciferase-lucife...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90567-2
更新日期:1989-04-24 00:00:00
abstract::The Mesulam technique for horseradish peroxidase was used to study the subcortical afferent projections to a location in the hypothalamus that has been shown to control the complete cardiovascular (CV) response accompanying a specific emotional behavior. Major projections common to all baboons injected included the la...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90389-4
更新日期:1982-12-09 00:00:00
abstract::The developmental time course and life span of the human brain are different from those of laboratory animals. These variations may be the reflection of metabolic differences of the neurons between different species. Using immunocytochemistry, we show that pyramidal neurons accumulate advanced glycosylation end produc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90156-2
更新日期:1994-04-04 00:00:00
abstract::The origin of the afferents of the thalamic anterior paraventricular and parataenial nuclei (PVA-PT) in the rat was studied with fluorescent retrograde tracing method. After iontophoretic application of Fluoro-Gold into PVA-PT, many labeled cells were found in the medial frontal cortex, ventral subiculum, claustrum, s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91570-7
更新日期:1990-07-02 00:00:00
abstract::The possibility that gamma-aminobutyric acid (GABA) could modulate sympathetic neurotransmission in the cerebrovascular bed of the goat has been investigated by means of 3 experimental approaches: measurement of cerebral blood flow in the anesthetized animal, recording of isometric tension in isolated cerebral arterie...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90887-1
更新日期:1989-07-17 00:00:00
abstract::This review summarizes the anatomical and functional organization of the frontal cortex of the rat in comparison to primates. Lesions of the primary motor or of the prefrontal cortex of both primates and rodents produce a consistent constellation of symptoms that are strikingly similar across species as diverse as rat...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/0165-0173(84)90018-3
更新日期:1984-11-01 00:00:00
abstract::In the vertebrate retina excitatory transmission seems to be mediated mainly by excitatory amino acids; glutamate and/or aspartate are the most viable candidates to subserve this function. Postsynaptic receptors for N-methyl-D-aspartate (NMDA), kainate (KA), quisqualate (QA) and 2-amino-4-phosphonobutyric acid have be...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91330-8
更新日期:1987-06-23 00:00:00
abstract::Although extracellular matrix (ECM) glycoproteins play important roles in neural development, their levels are generally believed to decrease in the adult brain. Immunohistochemical analysis indicates that the anti-adhesive ECM glycoprotein SPARC/osteonectin, which contains a follistatin 'module,' is expressed in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00101-u
更新日期:1995-04-03 00:00:00
abstract::The postnatal development of the terminal Schwann cell, an analogue of the lamellar cell in cutaneous sensory receptors, was examined by histochemistry for non-specific cholinesterase and immunohistochemistry for S-100 protein in the periodontal Ruffini endings of the rat incisor. Double immunohistochemistry for S-100...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02463-4
更新日期:2000-03-06 00:00:00
abstract::Deacetylation is a rapid clearance mechanism for ocular melatonin. We have studied the distribution of retinal melatonin deacetylase activity among vertebrate classes. Exogenous radiolabeled melatonin is metabolized by ocular tissue prepared from the amphibian Xenopus laevis, the reptile Anolis carolinensis, the teleo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90286-5
更新日期:1991-09-13 00:00:00
abstract::The suprachiasmatic nucleus (SCN) is involved in regulating many biological rhythms. Several lines of research implicate the SCN in affective behavior. The SCN is directly involved in regulating the daily rhythms of the hypothalamo-pituitary-adrenal (HPA) axis hormones involved in stress. Bilateral lesions of the SCN ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.11.063
更新日期:2004-03-19 00:00:00
abstract::Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness worldwide. Previous MRI studies have revealed that POAG can be associated with alterations in hippocampal function. Thus, the aim of this study was to investigate a relationship between chronic high intraocular pressure (IOP) and hippocamp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.09.001
更新日期:2017-11-15 00:00:00