Abstract：
:Release of Ca(2+) from intracellular Ca(2+) stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca(2+) source for the increased susceptibility to long-term depression (LTD) with advanced age is unknown. Extracellular excitatory postsynaptic field potentials were recorded from CA3-CA1 synaptic contacts from hippocampal slices obtained from young (5-8 months) and aged (22-24 months) male Fischer 344 rats. Blockade of Ca(2+)-release from ICS by cyclopiazonic acid, thapsigargin, or ryanodine blocked LTD induction in aged rats. Impaired LTD was not simply due to a loss of a Ca(2+) source. The idea that ICS may play prominent role in regulating synaptic modifiability through regulation of cell excitability and the timing of pre and postsynaptic activity is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Kumar A,Foster TCdoi
10.1016/j.brainres.2004.10.023subject
Has Abstractpub_date
2005-01-07 00:00:00pages
125-8issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(04)01707-Xjournal_volume
1031pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Homogenates of rat ventral and dorsal spinal cords were subjected to differential and gradient centrifugation on linear sucrose gradients following lysis of a synaptosomal fraction. The distribution of calcitonin gene-related peptide (CGRP) and substance P (SP) in dorsal spinal cord as well as the distribution of sero...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90780-4
更新日期：1989-10-16 00:00:00
abstract：:Glial cells play a crucial role in the pathomechanism of perinatal hypoxic-ischemic brain injury (HI) and are involved in the maintenance of a chronic state of inflammation that causes delayed neuronal damage. Activation of astrocytes is one factor prolonging brain damage and contributing to the formation of a glial s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.05.066
更新日期：2012-12-03 00:00:00
abstract：:The climbing fiber input to the cerebellar cortex was destroyed using both electrolytic and chemical (3-acetylpyridine) lesions. The long-term effects of climbing fiber deafferentation on the ansiform lobule of weanling and adult rats were examined at both the light and electron microscopic levels. Image analysis of G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90022-3
更新日期：1986-09-24 00:00:00
abstract：:The so-called on- and off-cells of the rostral ventromedial medulla (RVM) send their axons to the spinal dorsal horn. Activation of on-cells precedes and coincides with a facilitation, and activation of off-cells coincides with an inhibition, of withdrawal reflexes elicited by noxious agents. Considerable evidence sup...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.02.025
更新日期：2018-05-01 00:00:00
abstract：:The influence of dopamine D1 receptor agonist, SKF 38393 has been studied in vitro in the model of low calcium spontaneous epileptiform discharges. Application of SKF 38393 (3 microM) to the perfusing medium evoked a decrease in neuronal firing rate of hippocampal CA1 neurons. The effect of SKF 38393 was blocked by pr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90208-s
更新日期：1990-09-24 00:00:00
abstract：:Our previous studies demonstrated that only a few days of housing in an enriched environment increases response strength and paired-pulse depression in the auditory cortex of awake and anesthetized rats [Engineer, N.D., Percaccio, C.R., Pandya, P.K., Moucha, R., Rathbun, D.L., Kilgard, M.P., 2004. Environmental enrich...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.062
更新日期：2007-10-12 00:00:00
abstract：:The response of trunk neural crest cells taken from precise levels of the neural axis and cultured together with adjacent somites to Brain-derived neurotrophic factor (BDNF), was examined in cultures grown in a chemically defined medium. In control cultures, the number of neural crest-derived neurons expressing the HN...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90171-x
更新日期：1988-06-01 00:00:00
abstract：:Ethanol withdrawal (ETX) after induction of ethanol dependence results in a syndrome that includes enhanced seizure susceptibility. During ETX in rodents, generalized audiogenic seizures (AGS) can be triggered by intense acoustic stimulation. Previous studies have implicated specific brainstem nuclei in the neuronal n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.017
更新日期：2007-04-13 00:00:00
abstract：:Ligation of CD27, a member of the tumor necrosis factor (TNF) receptor family, by its ligand CD70 is thought to be important in T cell activation, expansion and survival, B cell activation, and NK cell activation. We examined the role of CD70 in Theiler's murine encephalomyelitis virus-induced demyelinating disease (T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.058
更新日期：2010-03-04 00:00:00
abstract：:Nerve growth factor (NGF) treatment, given as a single 200 BU intraocular injection at the time of optic nerve transection, was found to significantly accelerate the retinal ganglion cell response to axotomy in the newt (Notophthalmus viridescens). In the control series the per cent of neurons in the retinal ganglion ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90327-5
更新日期：1979-08-03 00:00:00
abstract：:Identifiable giant neurons of Aplysia explored intracellularly behave differently at the offset of an intracellular electroshock (IES) or after a synaptic 'tetanization', according to their functional type: neurons of the stable type depolarize and fire at the offset of the IES, anodal or cathodal, thus eliciting an a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90583-2
更新日期：1982-09-30 00:00:00
abstract：:Slices of rat hippocampus were exposed to 700 MHz continuous wave radiofrequency (RF) fields (25.2-71.0 V m(-1), 5-15 min exposure) in a stripline waveguide. At low field intensities, the predominant effect on the electrically evoked field potential in CA1 was a potentiation of the amplitude of the population spike by...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02434-9
更新日期：2001-06-15 00:00:00
abstract：:The suprachiasmatic nucleus (SCN) of the anterior hypothalamus is implicated in the temporal organization of circadian rhythms in a variety of physiological, endocrine and behavioral processes. There is a great deal of evidence indicating that aging is characterized by a progressive deterioration of circadian timekeep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90689-0
更新日期：1994-07-18 00:00:00
abstract：:Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01590-5
更新日期：1999-07-24 00:00:00
abstract：:Strong evidence obtained from in vivo and ex-vivo studies suggests the existence of interaction between dopaminergic and nitrergic systems. Some of the observations suggest a possible implication of nitric oxide (NO) in dopamine (DA) uptake mechanism. The present work investigated the interaction between both systems ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.12.054
更新日期：2008-03-10 00:00:00
abstract：:The object of this study was to quantify and compare the degree of control monkeys may assert over firing patterns of normal and epileptic neurons. Thirty-seven epileptic and 70 normal neurons were studied in detail. The operant task was for the monkey to generate specified consecutive interspike intervals (ISI). The ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90884-3
更新日期：1978-08-04 00:00:00
abstract：:Visuomotor behavior and pattern discrimination were studied in a group of cats raised with one eye closed by eyelid suturing 7-10 days after birth. At the age of 8-10 months the animals were forced to use their deprived eye by reversal of eye closure (closing the normal eye and opening the deprived one). Visuomotor be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90771-x
更新日期：1976-07-30 00:00:00
abstract：:There is no sex difference in the number of axodendritic synapses in the lateral septum of adult rats. However, the treatment of adult females with estradiol (E2) for 4 weeks increases significantly the number of synapses, whereas E2 treatment fails to increase the synaptic number in males, suggesting a possible sexua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91574-5
更新日期：1987-12-08 00:00:00
abstract：:In pentobarbitone-anesthetized cats, the spike sequences of dorsal horn neurons were recorded in response to random stimulation of branches of the suralis nerve. Combined frequency- and time-domain analysis was performed on the stimulus and spike trains. Coherence function estimates computed by spectral analysis were ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90598-7
更新日期：1988-10-11 00:00:00
abstract：:Serotonin (5-HT) 1A receptors have been implicated in a variety of conditions including, depression, suicidal behavior, and aggression. Post-mortem brain studies and in vivo imaging studies report a variety of age and sex effects on brain 5-HT(1A) binding. Behavioral data from 5-HT(1A) specific pharmacological challen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03243-2
更新日期：2002-11-08 00:00:00
abstract：:The action of 5-hydroxytryptamine (5-HT) via the 5-HT1A receptor on dissociated rat dorsal raphe neurons was characterized under the whole-cell mode by using the nystatin-perforated patch-clamp technique. Under voltage-clamp conditions, 5-HT induced an inwardly rectifying K+ current (I5-HT) in a concentration-dependen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01141-9
更新日期：1997-01-16 00:00:00
abstract：:An in vitro autoradiographic technique has been used to localize [125I]omega-conotoxin GVIA binding sites in the brains of normal and cerebellar mutant mice. In the brains of normal mice, the highest densities of binding sites were observed at glomeruli of the olfactory bulb, cerebral cortex, caudate nucleus-putamen, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90004-8
更新日期：1989-06-05 00:00:00
abstract：:The present study utilized the [14C]2-deoxyglucose (2-DG) cell labeling procedure to characterize a functional pathway from the prefrontal cortex (Pfc) and mediodorsal thalamic nucleus (MD) to the hypothalamus. Rats were injected with 2-DG prior to a 45 min experimental paradigm consisting of alternating 30 s on-off p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90151-3
更新日期：1984-09-24 00:00:00
abstract：:Pretreatment with the alpha(2)-adrenoceptor agonist clonidine (31.25, 62.5, or 125 microg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the alpha(2)-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.020
更新日期：2004-09-24 00:00:00
abstract：:The effect of maternal hyperthermia on the developmental state of newborn guinea pig brains has been studied. Mean litter size and mean body weights of young from control and experimental mothers did not differ. Mean brain weight of young from control mothers (2.72 +/- 0.02 g) was larger than that from experimental mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90306-7
更新日期：1984-06-01 00:00:00
abstract：:The recently identified neuropeptide QRFP(26) is predominantly expressed in the hypothalamus and was suggested to play a role in the regulation of food intake following the observation of an acute orexigenic effect after central administration in mice. QRFP(26) exerts its effect via GPR103 and a newly identified recep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.055
更新日期：2006-11-13 00:00:00
abstract：:We have investigated the possibility that there is a correlation between female sexual receptivity and CNS serotonergic activity. In ovariectomized rats primed with a submaximal steroid regime of 2 micrograms oestradiol benzoate (OB) plus 0.2 mg progesterone (P), so that only a proportion were receptive, the 5-hydroxy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91575-6
更新日期：1985-05-06 00:00:00
abstract：:Glutamate N-methyl-D-aspartate receptors (NMDARs) in the medial prefrontal cortex (mPFC) and hippocampus may play an integral role in complex cognitive and social deficits associated with a number of psychiatric illnesses including autism, mood disorders, and schizophrenia. We used localized infusions of adeno-associa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.10.037
更新日期：2015-03-10 00:00:00
abstract：:The present study examined the behavioral effects of dopamine receptor agonists, antagonists, or N-methyl-D-aspartate (NMDA) glutamate receptor antagonist in rats with a unilateral excitotoxic lesion of the globus pallidus (GP). After the unilateral GP lesions were made by injections of the ibotenic acid, drugs were s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01241-9
更新日期：1998-01-19 00:00:00
abstract：:1-(p-Bromobenzoyl)-piperazine-2,3-dicarboxylic acid (pBB-PzDA; 0.03-5 mM), an excitatory amino acid antagonist, was perfused through the guinea pig cochlea while monitoring various cochlear potentials. pBB-PzDA (1-5 mM) reversibly suppressed the amplitude of the compound action potential of the auditory nerve (CAP) an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90934-7
更新日期：1989-05-15 00:00:00
