Abstract:
:We have investigated the possibility that there is a correlation between female sexual receptivity and CNS serotonergic activity. In ovariectomized rats primed with a submaximal steroid regime of 2 micrograms oestradiol benzoate (OB) plus 0.2 mg progesterone (P), so that only a proportion were receptive, the 5-hydroxyindoleacetic acid:5-hydroxytryptamine (5-HT) ratio in the hypothalamus was greater in the receptive compared to the non-receptive rats. When rats were primed with 10 micrograms OB alone, there was no difference in 5-HT activity in the receptive and non-receptive animals. Depletion of hypothalamic 5-HT levels by p-chlorophenylalanine methyl ester (PCPA) inhibited behaviour normally induced by OB plus P and this could be reversed by 5-hydroxytryptophan. PCPA had no effect in animals made receptive by OB alone. This indicates that P, but not OB, exerts its stimulatory effect on sexual behaviour via increasing 5-HT activity. Administration of 5-HT into the lateral, but not 3rd ventricle stimulated sexual behaviour and systemic injection of the selective 5-HT1 and 5-HT2 agonists, Ru 24969 and MK 212, inhibited and stimulated behaviour, respectively. It is suggested that 5-HT has a dual effect on female sexual receptivity acting via different systems, the inhibitory tract acting on 5-HT1 and the stimulatory tract on 5-HT2 receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Wilson CA,Hunter AJdoi
10.1016/0006-8993(85)91575-6subject
Has Abstractpub_date
1985-05-06 00:00:00pages
223-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(85)91575-6journal_volume
333pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Scratching elicited by the intrathecal (i.t.) administration of substance P (SP) into the lumbosacral spinal cord of rats was not reduced by spinalization or i.t. pretreatment with the analgesic morphine. Spinalization also did not affect scratching elicited by i.t. kainic acid and potentiated scratching elicited by i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90081-9
更新日期:1988-07-12 00:00:00
abstract::The concentration of extracellular Ca2+ has been shown to enhance or attenuate [3H]acetylcholine (ACh) release subsequent to a conditioning stimulus in rat brain hippocampal slices. Slices were incubated in vitro in [3H]choline solution. Subsequently the slices were subjected to two consecutive electrical stimulations...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90261-7
更新日期:1987-09-08 00:00:00
abstract::The purpose of this study was to investigate the influence of different adenosine triphosphate (ATP) concentrations (ranging from 400 nM to 250 microM) on hippocampal potentials recorded from pyramidal neurons. ATP applied at a concentration of 400 nM induced a 100% increase in the size of the population spike (potent...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90070-x
更新日期:1989-07-10 00:00:00
abstract::Reciprocal interactions between nitrergic and dopaminergic systems play a key role in the control of motor behavior. In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and monoamine metabolism in the striatum and substantia nigra of unilater...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.08.006
更新日期:2015-11-02 00:00:00
abstract::Transplantation of fetal substantia nigra into the brain can alleviate some of the manifestations of animal models of Parkinson's disease. The purpose of the present experiment was to determine the optimal embryonic donor age for solid tissue substantia nigra grafts. Rats with unilateral substantia nigra lesions were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90652-r
更新日期:1990-10-15 00:00:00
abstract::uinea pig antiserum specific to the purified bovine choline acetyltransferase was used to demonstrate the localization of this enzyme in rabbit forebrain by the peroxidase-antiperoxidase immunohistochemical method. Choline acetyltransferase was localized in olfactory bulb, olfactory tract, olfactory tubercle, piriform...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90196-2
更新日期:1982-03-04 00:00:00
abstract::Regulation of the intracellular calcium concentration ([Ca(2+)](i)) is of critical importance for synaptic function. Therefore, neurons buffer [Ca(2+)](i) using intracellular Ca(2+)-binding proteins (CaBPs). Previous evidence suggests that Calbindin-D(28K) (CB), an abundantly expressed endogenous fast CaBP, plays an i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.02.036
更新日期:2012-04-23 00:00:00
abstract::Alpha-bungarotoxin binding sites in chick retina from 12 days in ovo to hatching, were visualized at the ultrastructural level by use of a 1:1 conjugate of horseradish peroxidase with alpha-bungarotoxin. At all stages binding sites in the inner plexiform layer were localized in synapses, predominantly on or near the p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90774-x
更新日期:1980-11-10 00:00:00
abstract::A basic experiment of peripheral nerve regeneration using neuronal progenitor cells embedded in collagen gel was performed in a rat sciatic nerve defect. First, when neuronal progenitor cells derived from the fetal rat hippocampus were cultured in atelocollagen-containing medium, neurospheres positive for anti-nestin ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02539-3
更新日期:2003-06-06 00:00:00
abstract::Evidence from human and animal studies has shown that experiences of early attachment can influence brain development and structure. Adult attachment style develops from early attachment experiences. However, little is known about the relationship between gray matter volume and attachment style. Further, the structura...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.06.035
更新日期:2018-11-15 00:00:00
abstract::Alzheimer's disease (AD) classically presents with gray matter atrophy, as well as feature significant white matter abnormalities. Previous evidence indicates the overall burden of these pathological changes continues to advance as the disease progresses. The aim of this study was to investigate whether pathological a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.03.052
更新日期:2013-06-17 00:00:00
abstract::The importance of Na+/Ca2+ exchangers in the regulation of the physiological and pathological functions of the nervous system has been widely recognized. In this study, we used primary cultured E14.5 cortical neurons as a model system to study the possible roles of the reverse mode Na+/Ca2+ exchange activity in neurot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.01.042
更新日期:2008-03-27 00:00:00
abstract::Phenoxybenzamine can selectively eliminate the s-IPSP, in the presence of anti-cholinesterases that enhance s-IPSP and s-EPSP; and the alpha 2-antagonist, yohimbine, can partially but consistently depress s-IPSP selectively. The results provide positive pharmacological support for the monoaminergic nature of the trans...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90321-3
更新日期:1982-06-24 00:00:00
abstract::The temporal and spatial distribution of immunocytochemically identified reactive astrocytes is described following a cerebral stab wound in adult rats. Different patterns of reactivity were observed in the cerebral cortex, the corpus callosum and the deep structures of the hemisphere. In the cerebral cortex, the zone...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91499-4
更新日期:1985-02-18 00:00:00
abstract::Horseradish peroxidase (HRP, 30% solution, 0.1-0.3 mul, 72 h) was injected unilaterally into the basal striatum (STR) and the dorsal ventricular ridge (DVR) of adult turtles (Chrysemys picta) in order to demonstrate the cells of origin of some afferents to these telencephalic structures. After selective STR injection,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90161-x
更新日期:1976-05-21 00:00:00
abstract::Little is known about the movement of 5-aminolevulinic acid (delta-aminolevulinic acid; ALA) between blood and brain. This is despite the fact that increases in brain ALA may be involved in generating the neuropsychiatric symptoms in porphyrias and that systemic administration of ALA is currently being used to delinea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03749-6
更新日期:2003-01-10 00:00:00
abstract::Neurturin (NTN) is a recently discovered neurotrophic factor related to glial cell line-derived neurotrophic factor (GDNF) and has a wide spectrum of biological roles in different types of neurons in the central and peripheral nervous systems. However, information on its expression in peripheral tissues has been limit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01590-5
更新日期:1999-07-24 00:00:00
abstract::The effects of stimulating the reticular formation were studied during fictive locomotion in lampreys (Ichthyomyzon unicuspis). The in vitro isolated preparation of the brainstem and spinal cord was used and fictive locomotion was induced by bath application of N-methyl-D-aspartate (NMDA; 50-100 microM). During differ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00151-0
更新日期:1997-04-11 00:00:00
abstract::Sites which bind oxytocin and vasopressin with high affinity were detected in the brain and upper spinal cord of 12 human subjects, using in vitro light microscopic autoradiography. Tissue sections were incubated with tritiated vasopressin, tritiated oxytocin or an iodinated oxytocin antagonist. The ligand specificity...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90345-v
更新日期:1991-08-02 00:00:00
abstract::Benzodiazepine binding sites are present on gamma-aminobutyric acid (GABA) receptors in hippocampal neurons. Diazepam is known to potentiate the amplitude and prolong the decay of GABA(A) receptor-mediated inhibitory postsynaptic currents (IPSCs). In this study, benzodiazepine involvement in long-term potentiation (LT...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.008
更新日期:2005-11-16 00:00:00
abstract::Previous findings from this laboratory demonstrating changes in dopamine (DA) transporter and D2 receptors in the amygdaloid complex of subjects with major depression indicate that disruption of dopamine neurotransmission to the amygdala may contribute to behavioral symptoms associated with depression. Quantitative re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.02.009
更新日期:2008-05-01 00:00:00
abstract::Quantitative morphological changes in the superior colliculus (SC) and the parabigeminal nucleus (PB) were studied in hereditary bilaterally microphthalmic rat, which lacks the optic nerve completely. Volumes of the retinorecipient superficial collicular layers of SC (SCS) to the central gray matter were decreased by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(85)90012-4
更新日期:1985-11-01 00:00:00
abstract::The presence of an adrenergic projection from the nucleus of the tractus solitarius (NTS) to the parabrachial nucleus (PB) was demonstrated by the immunocytochemistry combined with a retrograde tracing method. Numerous neurons containing both phenylethanolamine N-methyltransferase, a marker for adrenaline, and wheat g...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90654-3
更新日期:1988-09-06 00:00:00
abstract::Corticotropin-releasing factor (CRF) in the brain plays an important role in regulations of physiological and behavioral processes, yet CRF distribution in tree shrew brain has not been thoroughly and systematically reported. Here we examined the distribution of CRF immunoreactivity in the brain of tree shrews (Tupaia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.06.004
更新日期:2015-08-27 00:00:00
abstract::Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.023
更新日期:2018-08-01 00:00:00
abstract::Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90442-4
更新日期:1980-09-15 00:00:00
abstract::The central nervous system of the snail Helisoma duryi contains porcine insulin-immunoreactive cells. Most of these cells are known as neurosecretory mediodorsal cells (MDC), and are involved in regulation of growth. There are about 25-40 large and small MDC in each cerebral ganglion near the commissure. Besides the M...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90933-z
更新日期:1992-05-15 00:00:00
abstract::When N-methyl-D,L-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90076-2
更新日期:1982-10-14 00:00:00
abstract::The effects of prostaglandin E1 (PGE1) on porcine cerebral arteries were studied in the absence and presence of cyclooxygenase inhibitors, 5 x 10(-6) M indomethacin or 10(-4) M aspirin. In preparations placed at a resting tension, 3 x 10(-9) to 10(-6) M PGE1 caused dose-dependent contractions. In prostaglandin F2 alph...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91096-2
更新日期:1989-09-04 00:00:00
abstract::Current responses to acetylcholine (ACh) and to suberyldicholine (D-6) applied from the double-barrelled ionophoretic micropipette were studied in two identified neurones (LPed-2 and LPed-3) isolated from the left ganglion of pulmonate mollusc, Planorbarius corneus. Experiments made with K2SO4-filled microelectrodes s...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91232-x
更新日期:1982-06-03 00:00:00