Abstract：
:Histone deacetylase 1 (HDAC1) plays a crucial role in cancer progression and development. This enzyme has been confirmed to be a key regulator of tumor biology functions, such as tumor cell proliferation, migration and invasion. However, HDAC1 expression in glioma remains controversial, and its specific function and molecular mechanism in glioblastoma is poorly understood. In this study, our findings demonstrated that protein and mRNA levels of HDAC1 were increased in glioma cell lines and glioma tissues compared to normal glial cell lines and non-neoplastic brain tissues, respectively. Furthermore, HDAC1 knockdown cells displayed decreased proliferation and invasion capabilities, whereas HDAC1 overexpressing glioblastoma cells displayed more proliferation and invasion capabilities in vitro. These novel outcomes suggested that knockdown of HDAC1 possibly suppressed the expression of phosphorylated AKT (p-AKT) and phosphorylated ERK (p-ERK) proteins, while overexpression of HDAC1 significantly increased p-AKT and p-ERK protein in glioblastoma cells. In addition, knockdown of HDAC1 repressed subcutaneous tumor growth in vivo, and led to down-regulation of p-AKT and p-ERK protein in U87 MG xenograft tumors. For the first time, we have demonstrated that HDAC1 promotes proliferation and invasion in glioblastoma cells by activating PI3K/AKT and MEK/ERK signaling pathways in vitro and in vivo. These results suggest that HDAC1 may be a novel biomarker and potential therapeutic target in glioblastoma.
journal_name
Brain Resjournal_title
Brain researchauthors
Li S,Chen X,Mao L,Zahid KR,Wen J,Zhang L,Zhang M,Duan J,Duan J,Yin X,Wang Y,Zhao L,Tang X,Wang X,Xu Gdoi
10.1016/j.brainres.2018.05.023subject
Has Abstractpub_date
2018-08-01 00:00:00pages
154-162eissn
0006-8993issn
1872-6240pii
S0006-8993(18)30280-4journal_volume
1692pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Spinal cord injury (SCI) often results in some form of paralysis. Recently, SCI therapy has been focused on preventing secondary injury to reduce both neuroinflammation and lesion size so that functional outcome after an SCI may be improved. Previous studies have shown that adenosine receptors (AR) are a major regulat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.12.053
更新日期：2016-03-01 00:00:00
abstract：:The present study was undertaken to disclose temporal changes in the distribution of Fos-like immunoreactive (-IR) neurons in the trigeminal subnucleus caudalis (SpVc), one of the important relay nuclei for processing the nociceptive information from the oro-facial regions, following induction of experimental tooth mo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01323-7
更新日期：1999-02-20 00:00:00
abstract：:In degenerating frog sciatic nerves an in situ perfusion technique was used to measure the permeability coefficient-surface area product (PA) of endoneurial capillaries to [14C]sucrose, and the endoneurial vascular space (V). Both PA and V started to increase after the 3rd day of degeneration. The increase in PA peake...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91091-8
更新日期：1988-03-29 00:00:00
abstract：:The feeding responses induced by systemic administration of 2-deoxy-D-glucose (2-DG) and paraventricular hypothalamic injection of norepinephrine were assessed in Brattleboro rats deficient in vasopressin (VP). Controlling for the non-specific complications of diabetes insipidus, it was found that Brattleboro rats hav...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91070-x
更新日期：1986-10-22 00:00:00
abstract：:Given that relatively little is known regarding the central control of brown adipose tissue (BAT)-mediated thermogenesis the present study assessed whether the direct pharmacological stimulation of beta- or alpha-adrenergic receptors located on the brown adipocytes would result in a typical thermogenic response follow...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91482-g
更新日期：1991-04-19 00:00:00
abstract：:The aim of this study was to determine if a prolonged period (7 or 14 days) of hypodynamia-hypokinesia (HH) affects the conduction of afferent input and the cortical and spinal responsiveness. Acute recordings of cortical and spinal somatosensory evoked potentials (SEPs) were performed after stimulation of the sciatic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02804-x
更新日期：2003-07-18 00:00:00
abstract：:Prolonged electrical stimulation of the perforant pathway in the rat evokes epileptiform discharges in dentate granule cells and irreversibly damages hilar neurons. In this in vivo study, we demonstrate that similar perforant path stimulation in C57Bl/6 mice causes the same pattern of hippocampal neuron loss. Therefor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.055
更新日期：2006-04-26 00:00:00
abstract：:Iontophoretic injection of cAMP elicits a slow, transient inward current in identified buccal feeding motoneurons and in the giant cerebral interneuron of the snail, Lymnaea stagnalis. The current is voltage independent, and is abolished in the absence of extracellular Na+. Application of the phosphodiesterase inhibit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91330-3
更新日期：1988-01-12 00:00:00
abstract：:Aging is accompanied by an impairment of associative memory. The medial temporal lobe and fronto-striatal network, both involved in associative memory, are known to decline functionally and structurally with age, leading to the so-called associative binding deficit and the resource deficit. Because the MTL and fronto-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.011
更新日期：2010-02-22 00:00:00
abstract：:Rats were administered haloperidol (0.5 mg/kg/day) for 21 days. Twenty percent of locus coeruleus (LC) neurons recorded were not spontaneously active, while no such neuron was observed in control animals. A further 22% of neurons (spontaneously active) had rates greater than 2 standard deviations from the mean of LC c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90346-4
更新日期：1985-01-28 00:00:00
abstract：:Ovine corticotropin releasing factor (CRF) given intracerebroventricularly to rhesus monkeys at doses of 0.1-1 microgram/kg activates the pituitary-adrenal axis. The increases of plasma cortisol concentrations after intraventricular injection of CRF were similar to those observed after intravenous administration of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90315-9
更新日期：1984-12-10 00:00:00
abstract：:In our study, we examined middle cerebral artery (MCA) contractile responses in two animal models. After hemorrhagic disturbances in rats of Krushinsky-Molodkina strain (KMRs) a decrease in contractile responses to serotonin (5-HT) was observed. During incomplete global cerebral ischemia, MCAs had increased responsive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.062
更新日期：2004-01-02 00:00:00
abstract：:The 'commissural' innervation of the dentate gyrus molecular layer has been analyzed in normal adult rats and in those in which the ipsilateral entorhinal cortex had been removed by aspiration at 14 days post-natal. This ablation severely deafferents the distal two-thirds of the molecular layer and induces 'sprouting'...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90512-2
更新日期：1979-10-12 00:00:00
abstract：:(1) Synaptic transmission was studied in isolated transverse hippocampal slices from guinea pigs. Extracellular evoked potentials were recorded in the region CA1. (2) Changing the normal perfusion solution (containing 2 mM Ca2+) to calcium-free Ringer abolished synaptic transmission which was again restored by adding ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91327-x
更新日期：1980-07-21 00:00:00
abstract：:Ethanol withdrawal (ETX) after induction of ethanol dependence results in a syndrome that includes enhanced seizure susceptibility. During ETX in rodents, generalized audiogenic seizures (AGS) can be triggered by intense acoustic stimulation. Previous studies have implicated specific brainstem nuclei in the neuronal n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.017
更新日期：2007-04-13 00:00:00
abstract：:It is well established that extracellular choline is transported into central cholinergic nerve terminals by 'high' and 'low' affinity processes to form the neurotransmitter acetylcholine (ACh). The intent of the present investigation was to ascertain whether extracellular acetate might also be transported into centra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01485-0
更新日期：1997-04-04 00:00:00
abstract：:Using the histochemical Timm sulphide silver method, a strain-specific, increased stainability of the cell bodies of the dentate granule cells and the hippocampal pyramidal cells was observed in the inbred Kyoto rat. The resulting dense staining which also includes neurons in the neocortex and cerebellum can be used a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90081-7
更新日期：1986-09-01 00:00:00
abstract：:The default mode network (DMN) is characterised by coherent very low frequency (VLF) neural oscillations in the resting brain. The attenuation of this activity has been demonstrated following the transition from rest to performance of a broad range of cognitive goal-directed tasks. Whether the activity of resting stat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.05.043
更新日期：2013-08-02 00:00:00
abstract：:The distribution of antidiabetic sulfonylurea [( 3H]glibenclamide) binding sites is heterogeneous in rat brain. Pyramidal and extrapyramidal motor system contain the highest densities of sites, particularly in the substantia nigra and in the globus pallidus. Only low levels are present in the hypothalamic nuclei and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91288-2
更新日期：1989-05-01 00:00:00
abstract：:The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion. In comparison with the control group, indomethacin sig...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90248-8
更新日期：1994-08-01 00:00:00
abstract：:Corticotropin-releasing factor (CRF) and dynorphin-related peptides are co-localized within a subset of hypothalamic neurons suggesting the possibility of their co-release. Therefore, studies were performed in conscious unrestrained rats to examine whether dynorphin-related peptides modify the central nervous system (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90713-0
更新日期：1989-05-29 00:00:00
abstract：:This study examined the involvement of N-methyl-D-aspartate receptors (NMDARs) in experience-dependent synaptic plasticity. Rats chronically received an NMDA receptor antagonist (AP5) or saline (SAL) and were exposed to individual cages (IC) or environmental enrichment (EC). AP5 impaired measures of hippocampal-depend...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02379-9
更新日期：2000-07-14 00:00:00
abstract：:The objective was to further test the hypothesis that aluminum (Al) citrate transport across the blood-brain barrier is mediated by a monocarboxylate transporter (MCT). Speciation calculations showed that Al citrates were the predominant Al species under the conditions employed. Al citrate did not inhibit lactate upta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02234-5
更新日期：2002-03-15 00:00:00
abstract：:Recently it has been reported that prolactin (PRL) exerts a neuroprotective effect against excitotoxicity in hippocampus in the rat in vivo models. However, the exact mechanism by which PRL mediates this effect is not completely understood. The aim of our study was to assess whether prolactin exerts neuroprotection ag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.011
更新日期：2016-04-01 00:00:00
abstract：:The present study is a determination of the numbers of axons in the sural nerve and nerve to the medial gastrocnemius muscle following section and regeneration of the sciatic nerve in the rat. The data indicate that there is a significant increase in both myelinated and unmyelinated axons in the nerve to the medial ga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90819-9
更新日期：1984-03-12 00:00:00
abstract：:Dissociated Muller (glial) cells from the neotenous tiger salamander retina respond electrogenically and rheogenically to three putative catecholamine (CA) neurotransmitters, epinephrine, norepinephrine and dopamine. All 3 CAs stimulate a net inward current and an increase in input resistance (Rn). The Muller cell res...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90081-j
更新日期：1992-03-20 00:00:00
abstract：:In the present study we have examined the effects of changes in potassium and calcium concentration on the early adaptation of the slowly adapting stretch receptor of the crayfish using intracellular recordings including the potential clamp technique. This was because previous studies had suggested that the early adap...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90409-3
更新日期：1985-06-10 00:00:00
abstract：:alpha-Tocopherol (alpha-TC) is considered an important endogenous brain antioxidant. The utility of brain alpha-TC levels as an index of in vivo lipid peroxidation has recently been suggested. Therefore, we explored the significance of alpha-TC levels in brains to ischemic insults associated with global or focal cereb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91215-e
更新日期：1993-04-30 00:00:00
abstract：:Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90244-6
更新日期：1990-08-27 00:00:00
abstract：:The syndrome of vacuous chewing movements (VCMs) in rats is similar in many respects to tardive dyskinesia (TD) in humans. Both syndromes are characterized by delayed onset of persistent orofacial dyskinesias in a sub-group of subjects chronically treated with neuroleptics. Using the rat model, we examined the role of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00196-6
更新日期：1998-06-15 00:00:00
